• 947 Citations

Research output per year

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Personal profile

Research interests

We have recently discovered that HIV-1 Integrase protein regulates particle maturation, a role completely independent of its catalytic activity. This involves the binding of integrase to viral RNA molecules, which ensures the encapsidation of viral RNA and IN in the viral core. Remarkably, integrase-RNA interactions can be targeted by a novel class of compounds that are currently in clinical trials. Our goal is to discover novel compounds that directly target integrase-RNA interactions and determine their mechanism of action, which will be of great value in the clinical setting.

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Research Output

Clip for studying protein-RNA interactions that regulate virus replication

Shema Mugisha, C., Tenneti, K. & Kutluay, S. B., Jan 1 2019, (Accepted/In press) In : Methods.

Research output: Contribution to journalReview article

  • Genome-wide analysis of heterogeneous nuclear ribonucleoprotein (hnRNP) binding to HIV-1 RNA reveals a key role for hnRNP H1 in alternative viral mRNA splicing

    Kutluay, S. B., Emery, A., Penumutchu, S. R., Townsend, D., Tenneti, K., Madison, M. K., Stukenbroeker, A. M., Powell, C., Jannain, D., Tolbert, B. S., Swanstrom, R. I. & Bieniasz, P. D., Jan 1 2019, In : Journal of virology. 93, 21, e01048-19.

    Research output: Contribution to journalArticle

  • 2 Scopus citations

    CLIP-related methodologies and their application to retrovirology

    Bieniasz, P. D. & Kutluay, S. B., May 2 2018, In : Retrovirology. 15, 1, 35.

    Research output: Contribution to journalReview article

    Open Access
  • 7 Scopus citations
    Open Access
  • 23 Scopus citations

    Allosteric HIV-1 integrase inhibitors lead to premature degradation of the viral RNA genome and integrase in target cells

    Madison, M. K., Lawson, D. Q., Elliott, J., Ozantürk, A. N., Koneru, P. C., Townsend, D., Errando, M., Kvaratskhelia, M. & Kutluay, S. B., Sep 1 2017, In : Journal of virology. 91, 17, e00821-17.

    Research output: Contribution to journalArticle

    Open Access
  • 11 Scopus citations