Research output per year
Research output per year
Personal profile
Research interests
We have recently discovered that HIV-1 Integrase protein regulates particle maturation, a role completely independent of its catalytic activity. This involves the binding of integrase to viral RNA molecules, which ensures the encapsidation of viral RNA and IN in the viral core. Remarkably, integrase-RNA interactions can be targeted by a novel class of compounds that are currently in clinical trials. Our goal is to discover novel compounds that directly target integrase-RNA interactions and determine their mechanism of action, which will be of great value in the clinical setting.
Available to Mentor:
- PhD/MSTP Students
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Collaborations and top research areas from the last five years
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Calpain-2 mediates SARS-CoV-2 entry via regulating ACE2 levels
Zeng, Q., Antia, A., Casorla-Perez, L. A., Puray-Chavez, M., Kutluay, S. B., Ciorba, M. A. & Ding, S., Mar 2024, In: mBio. 15, 3Research output: Contribution to journal › Article › peer-review
Open Access -
Defining Distinct RNA-Protein Interactomes of SARS-CoV-2 Genomic and Subgenomic RNAs
Whitworth, I. T., Knoener, R. A., Puray-Chavez, M., Halfmann, P., Romero, S., Baddouh, M., Scalf, M., Kawaoka, Y., Kutluay, S. B., Smith, L. M. & Sherer, N. M., Jan 5 2024, In: Journal of Proteome Research. 23, 1, p. 149-160 12 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
HIV-1 capsid stability and reverse transcription are finely balanced to minimize sensing of reverse transcription products via the cGAS-STING pathway
Eschbach, J. E., Puray-Chavez, M., Mohammed, S., Wang, Q., Xia, M., Huang, L. C., Shan, L. & Kutluay, S. B., May 2024, In: mBio. 15, 5Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Thermodynamic coupling of the tandem RRM domains of hnRNP A1 underlie its pleiotropic RNA binding functions
Levengood, J. D., Potoyan, D., Penumutchu, S., Kumar, A., Zhou, Q., Wang, Y., Hansen, A. L., Kutluay, S., Roche, J. & Tolbert, B. S., Jul 2024, In: Science Advances. 10, 28, adk6580.Research output: Contribution to journal › Article › peer-review
Open Access -
Emergence of Compensatory Mutations Reveals the Importance of Electrostatic Interactions between HIV-1 Integrase and Genomic RNA
Mugisha, C. S., Dinh, T., Kumar, A., Tenneti, K., Eschbach, J. E., Davis, K., Gifford, R., Kvaratskhelia, M. & Kutluay, S. B., Oct 26 2022, In: mBio. 13, 5, p. e0043122Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations