Sean Whelan

Professor of Molecular Microbiology, Head of the Department of Molecular Microbiology, Marvin A Brennecke Distinguished Professor of Molecular Microbiology

    • 14252
      Citations
    1994 …2022

    Research activity per year

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    Research interests

    The Whelan laboratory studies the biology of negative-strand (NS) RNA viruses. These viruses have genomes that are complementary to message sense RNA and must therefore carry into the cell the necessary machinery to copy their genomic RNA into mRNA. The genomes of the viruses can be non-segmented (ns) or segmented (s). We use vesicular stomatitis virus (VSV) as a model for the nsNS RNA viruses. The nsNS RNA viruses include some of the most significant human pathogens, as well as a number of highly lethal emerging infections. The work of the laboratory is divided between two major areas of focus: studies of viral gene expression and studies on viral-host cell interactions.

    Keywords

    • COVID-19

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    • Antibody-mediated broad sarbecovirus neutralization through ACE2 molecular mimicry

      Park, Y. J., De Marco, A., Starr, T. N., Liu, Z., Pinto, D., Walls, A. C., Zatta, F., Zepeda, S. K., Bowen, J. E., Sprouse, K. R., Joshi, A., Giurdanella, M., Guarino, B., Noack, J., Abdelnabi, R., Caroline Foo, S. Y., Rosen, L. E., Lempp, F. A., Benigni, F., Snell, G., & 7 othersNeyts, J., Whelan, S. P. J., Virgin, H. W., Bloom, J. D., Corti, D., Pizzuto, M. S. & Veesler, D., Jan 28 2022, In: Science. 375, 6579

      Research output: Contribution to journalArticlepeer-review

      30 Scopus citations
    • BSL2-compliant lethal mouse model of SARS-CoV-2 and variants of concern to evaluate therapeutics targeting the Spike protein

      Manangeeswaran, M., Ireland, D. D. C., Thacker, S. G., Lee, H. N., Kelley-Baker, L., Lewkowicz, A. P., Rothlauf, P. W., Cornejo Pontelli, M., Bloyet, L. M., Eckhaus, M. A., Mendoza, M. I., Whelan, S. & Verthelyi, D., Jul 28 2022, In: Frontiers in immunology. 13, 919815.

      Research output: Contribution to journalArticlepeer-review

      Open Access
    • CD164 is a host factor for lymphocytic choriomeningitis virus entry

      Bakkers, M. J. G., Moon-Walker, A., Herlo, R., Brusic, V., Stubbs, S. H., Hastie, K. M., Saphire, E. O., Kirchhausen, T. L. & Whelan, S. P. J., Mar 8 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 10, e2119676119.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      2 Scopus citations
    • Defining the risk of SARS-CoV-2 variants on immune protection

      DeGrace, M. M., Ghedin, E., Frieman, M. B., Krammer, F., Grifoni, A., Alisoltani, A., Alter, G., Amara, R. R., Baric, R. S., Barouch, D. H., Bloom, J. D., Bloyet, L. M., Bonenfant, G., Boon, A. C. M., Boritz, E. A., Bratt, D. L., Bricker, T. L., Brown, L., Buchser, W. J., Carreño, J. M., & 110 othersCohen-Lavi, L., Darling, T. L., Davis-Gardner, M. E., Dearlove, B. L., Di, H., Dittmann, M., Doria-Rose, N. A., Douek, D. C., Drosten, C., Edara, V. V., Ellebedy, A., Fabrizio, T. P., Ferrari, G., Fischer, W. M., Florence, W. C., Fouchier, R. A. M., Franks, J., García-Sastre, A., Godzik, A., Gonzalez-Reiche, A. S., Gordon, A., Haagmans, B. L., Halfmann, P. J., Ho, D. D., Holbrook, M. R., Huang, Y., James, S. L., Jaroszewski, L., Jeevan, T., Johnson, R. M., Jones, T. C., Joshi, A., Kawaoka, Y., Kercher, L., Koopmans, M. P. G., Korber, B., Koren, E., Koup, R. A., LeGresley, E. B., Lemieux, J. E., Liebeskind, M. J., Liu, Z., Livingston, B., Logue, J. P., Luo, Y., McDermott, A. B., McElrath, M. J., Meliopoulos, V. A., Menachery, V. D., Montefiori, D. C., Mühlemann, B., Munster, V. J., Munt, J. E., Nair, M. S., Netzl, A., Niewiadomska, A. M., O’Dell, S., Pekosz, A., Perlman, S., Pontelli, M. C., Rockx, B., Rolland, M., Rothlauf, P. W., Sacharen, S., Scheuermann, R. H., Schmidt, S. D., Schotsaert, M., Schultz-Cherry, S., Seder, R. A., Sedova, M., Sette, A., Shabman, R. S., Shen, X., Shi, P. Y., Shukla, M., Simon, V., Stumpf, S., Sullivan, N. J., Thackray, L. B., Theiler, J., Thomas, P. G., Trifkovic, S., Türeli, S., Turner, S. A., Vakaki, M. A., van Bakel, H., VanBlargan, L. A., Vincent, L. R., Wallace, Z. S., Wang, L., Wang, M., Wang, P., Wang, W., Weaver, S. C., Webby, R. J., Weiss, C. D., Wentworth, D. E., Weston, S. M., Whelan, S. P. J., Whitener, B. M., Wilks, S. H., Xie, X., Ying, B., Yoon, H., Zhou, B., Hertz, T., Smith, D. J., Diamond, M. S., Post, D. J. & Suthar, M. S., May 26 2022, In: Nature. 605, 7911, p. 640-652 13 p.

      Research output: Contribution to journalReview articlepeer-review

      Open Access
      15 Scopus citations
    • Detection of Bourbon Virus-Specific Serum Neutralizing Antibodies in Human Serum in Missouri, USA

      Bamunuarachchi, G., Harastani, H., Rothlauf, P. W., Dai, Y. N., Ellebedy, A., Fremont, D., Whelan, S. P. J., Wang, D. & Boon, A. C. M., Jun 2022, In: mSphere. 7, 3

      Research output: Contribution to journalArticlepeer-review

      Open Access