• 27594 Citations
1985 …2020

Research output per year

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Personal profile

Research interests

Major interests have been in elucidating basic mechanisms of bacterial pathogenesis. His work as utilized a unique blend of a powerful genetic system with x-ray crystallography, protein chemistry, high resolution electron microscopy, immunology and cell biology to study the molecular details of host-pathogen interactions that occur during urinary tract infections (UTIs) caused by E. coli. He has become a world’s authority in issues relating to the structure and function of adhesive fibers called pili that play critical and unexpected roles in host-pathogen interactions. Studying UTIs, he found that bacterial entry into epithelial cells of the bladder provides a safe haven for bacterial persistence by activating the formation of intracellular bacterial communities (IBCs). Elucidation of the IBC program is changing the way UTIs are evaluated and treated and is re-shaping models of bacterial infections in general. His studies are teaching us fundamental aspects of bladder physiology that have implications for normal epithelial renewal and bladder cancer. He also is investigating amyloid-like fibers, called curli, produced by E. coli. This work has implications for the pathology of Alzheimer’s and other amyloid diseases. Work in his lab is spawning new technologies to design novel vaccines and anti-microbial therapeutics that will block the ability of bacteria to adhere to host tissues and prevent their ability to establish infections.

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Research Output

Adaptation of arginine synthesis among uropathogenic branches of the escherichia coli phylogeny reveals adjustment to the urinary tract habitat

Hibbing, M. E., Dodson, K. W., Kalas, V., Chen, S. L. & Hultgren, S. J., Sep 1 2020, In : mBio. 11, 5, p. 1-15 15 p., e02318-20.

Research output: Contribution to journalArticle

Open Access
  • Deposition of host matrix proteins on breast implant surfaces facilitates staphylococcus epidermidis biofilm formation: In vitro analysis

    Walker, J. N., Pinkner, C. L., Lynch, A. J. L., Ortbal, S., Pinkner, J. S., Hultgren, S. J. & Myckatyn, T., Feb 17 2020, In : Aesthetic surgery journal. 40, 3, p. 281-295 15 p.

    Research output: Contribution to journalArticle

  • 6 Scopus citations

    Establishment and Characterization of Bacterial Infection of Breast Implants in a Murine Model

    Walker, J. N., Poppler, L. H., Pinkner, C. L., Hultgren, S. J. & Myckatyn, T. M., Apr 14 2020, In : Aesthetic surgery journal. 40, 5, p. 516-528 13 p.

    Research output: Contribution to journalArticle

  • 1 Scopus citations

    Urinary tract infections: microbial pathogenesis, host–pathogen interactions and new treatment strategies

    Klein, R. D. & Hultgren, S. J., Apr 1 2020, In : Nature Reviews Microbiology. 18, 4, p. 211-226 16 p.

    Research output: Contribution to journalReview article

  • 6 Scopus citations

    (p)ppGpp and CodY promote Enterococcus faecalis virulence in a murine model of catheter-associated urinary tract infection

    Colomer-Winter, C., Flores-Mireles, A. L., Kundra, S., Hultgren, S. J. & Lemos, J. A., 2019, In : mSphere. 4, 4, e00392-19.

    Research output: Contribution to journalArticle

    Open Access
  • 3 Scopus citations