Personal profile
Research interests
Sanjay Jain is a Professor of Medicine, Pediatrics and Pathology & Immunology at the Washington University School of Medicine in St. Louis, Missouri, USA (WUSM). His laboratory focuses on how kidneys and the lower urinary tract develop and organize to maintain homeostasis across lifespan in health and disease. His has defined key developmental pathways and mechanisms that regulate the joining of primitive ureter and bladder, initiation of the collecting system and branching morphogenesis of the kidney and genetic mutations associated with CAKUT. He leads multiple NIH-sponsored atlas efforts to map healthy and disease states in the human kidney including HuBMAP, KPMP, RBK/GUDMAP and Pediatric Center of Excellence in Nephrology. The team has identified, validated and mapped ~100 cell identities in the kidney including healthy and injured cells and defined genes and pathways that help recovery or predict decline in kidney function. His lab is currently using cutting edge multimodal single cell and spatially resolved omics approaches to create 2D and 3D maps of the human kidney in health and disease in diverse populations across lifespan.
Education activities and interests
Our group is committed to provide opportunities to students and trainees from diverse backgrounds and underrepresented communities and various stages in their education (high school, undergraduates, medical students, post-bacs and graduate students, fellows, postdocs, early stage investigators). We are a participating lab in the HuBMAP and Pediatric Center of Excellence in Nephrology Summer scholar program. These provide experience in single cell technologies, wet lab, didactic courses and clinical shadowing related to the genitourinary system.
Mentoring
Training in using the R package for single cell analysis.
Wet lab experience in tissue processing, preservation, molecular biology techniques, 2D and 3D imaging, mouse dissection
histology, microscopy, data mining and analysis, single cell studies, transcriptomics
Keywords
- COVID-19
Available to Mentor:
- High School Students
- Undergraduate Students
- Post-Baccalaureate Students
- PhD Students
- Health Professions (Medical, OT, PT, Dental, Audiology, etc.) Students
- Postdocs
- Residents and Fellows
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Collaborations and top research areas from the last five years
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In vitro plasticity between ureteric epithelial and distal nephron identity and maturity is controlled by extracellular signals
Kairath, P., Er, P. X., Wilson, S., Ghobrial, I., Vanslambrouck, J. M., Chen, Y. H., Pruett-Miller, S. M., Jain, S. & Little, M. H., May 2026, In: Developmental Biology. 533, p. 75-88 14 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Kidney Biorepositories: Valuable Tools Advancing Acute Kidney Injury Research
Gewin, L. S., Parikh, C., Jain, S., Hung, A., Bajwa, A., Okusa, M., Kumar, S. & Mansour, S. G., Feb 2026, In: European journal of anaesthesiology. 7, 2, p. 426-434 9 p.Research output: Contribution to journal › Review article › peer-review
Open Access -
Cell Type Prediction for Intestine Tissue Samples from Brightfield Histology via Deep Learning
Mimar, S., Lucarelli, N., Devarasetty, S., Hickey, J., El-Ashkar, T., Eadon, M., Jain, S. & Sarder, P., 2025, Medical Imaging 2025: Digital and Computational Pathology. Tomaszewski, J. E. & Ward, A. D. (eds.). SPIE, 1341308. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 13413).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review
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Developing evaluation metrics to measure the US national institute of health plans to enhance diverse perspectives: a protocol for a consensus-based study
Levites Strekalova, Y. A., Jain, S. & Sarder, P., Feb 26 2025, In: BMJ Open. 15, 2, e087739.Research output: Contribution to journal › Article › peer-review
Open Access -
FUSION: a web-based application for in-depth exploration of multi-omics data with brightfield histology
HuBMAP Consortium, Dec 2025, In: Nature communications. 16, 1, 8388.Research output: Contribution to journal › Article › peer-review
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