Willing to Mentor

    Available to Mentor:

    Health Professions (Medical, OT, PT, Dental, Audiology, etc.) Students, High School Students, PhD/MSTP Students, Post-Baccalaureate Students, Postdocs, Residents and Fellows, Undergraduate Students

    • 7091
      Citations
    1990 …2024

    Research activity per year

    Personal profile

    Research interests

    Sanjay Jain is a Professor of Medicine, Pediatrics and Pathology & Immunology at the Washington University School of Medicine in St. Louis, Missouri, USA (WUSM). His laboratory focuses on how kidneys and the lower urinary tract develop and organize to maintain homeostasis across lifespan in health and disease. His has defined key developmental pathways and mechanisms that regulate the joining of primitive ureter and bladder, initiation of the collecting system and branching morphogenesis of the kidney and genetic mutations associated with CAKUT. He leads multiple NIH-sponsored atlas efforts to map healthy and disease states in the human kidney including HuBMAP, KPMP, RBK/GUDMAP and Pediatric Center of Excellence in Nephrology. The team has identified, validated and mapped ~100 cell identities in the kidney including healthy and injured cells and defined genes and pathways that help recovery or predict decline in kidney function. His lab is currently using cutting edge multimodal single cell and spatially resolved omics approaches to create 2D and 3D maps of the human kidney in health and disease in diverse populations across lifespan. 

    Education activities and interests

    Our group is committed to provide opportunities to students and trainees from diverse backgrounds and underrepresented communities and various stages in their education (high school, undergraduates, medical students, post-bacs and graduate students, fellows, postdocs, early stage investigators). We are a participating lab in the HuBMAP and Pediatric Center of Excellence in Nephrology Summer scholar program. These provide experience in single cell technologies, wet lab, didactic courses and clinical shadowing related to the genitourinary system. 

    Mentoring

    Training in using the R package for single cell analysis.
    Wet lab experience in tissue processing, preservation, molecular biology techniques, 2D and 3D imaging, mouse dissection
    histology, microscopy, data mining and analysis, single cell studies, transcriptomics 

    Keywords

    • COVID-19

    Available to Mentor:

    • High School Students
    • Undergraduate Students
    • Post-Baccalaureate Students
    • PhD/MSTP Students
    • Health Professions Students
    • Postdocs
    • Residents and Fellows

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    Collaborations and top research areas from the last five years

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    • Mapping human tissues with highly multiplexed RNA in situ hybridization

      Kalhor, K., Chen, C. J., Lee, H. S., Cai, M., Nafisi, M., Que, R., Palmer, C. R., Yuan, Y., Zhang, Y., Li, X., Song, J., Knoten, A., Lake, B. B., Gaut, J. P., Keene, C. D., Lein, E., Kharchenko, P. V., Chun, J., Jain, S., Fan, J. B., & 1 othersZhang, K., Dec 2024, In: Nature communications. 15, 1, 2511.

      Research output: Contribution to journalArticlepeer-review

      Open Access
    • Precision Medicine in Nephrology: An Integrative Framework of Multidimensional Data in the Kidney Precision Medicine Project

      Kidney Precision Medicine Project, Mar 2024, In: American Journal of Kidney Diseases. 83, 3, p. 402-410 9 p.

      Research output: Contribution to journalArticlepeer-review

      1 Scopus citations
    • Sensory neurons promote immune homeostasis in the lung

      Tamari, M., Del Bel, K. L., Ver Heul, A. M., Zamidar, L., Orimo, K., Hoshi, M., Trier, A. M., Yano, H., Yang, T. L., Biggs, C. M., Motomura, K., Shibuya, R., Yu, C. D., Xie, Z., Iriki, H., Wang, Z., Auyeung, K., Damle, G., Demircioglu, D., Gregory, J. K., & 13 othersHasson, D., Dai, J., Chang, R. B., Morita, H., Matsumoto, K., Jain, S., Van Dyken, S., Milner, J. D., Bogunovic, D., Hu, H., Artis, D., Turvey, S. E. & Kim, B., Jan 4 2024, In: Cell. 187, 1, p. 44-61.e17

      Research output: Contribution to journalArticlepeer-review

      Open Access
      2 Scopus citations
    • The chromatin landscape of healthy and injured cell types in the human kidney

      Gisch, D. L., Brennan, M., Lake, B. B., Basta, J., Keller, M. S., Melo Ferreira, R., Akilesh, S., Ghag, R., Lu, C., Cheng, Y. H., Collins, K. S., Parikh, S. V., Rovin, B. H., Robbins, L., Stout, L., Conklin, K. Y., Diep, D., Zhang, B., Knoten, A., Barwinska, D., & 333 othersAsghari, M., Sabo, A. R., Ferkowicz, M. J., Sutton, T. A., Kelly, K. J., De Boer, I. H., Rosas, S. E., Kiryluk, K., Hodgin, J. B., Alakwaa, F., Winfree, S., Jefferson, N., Türkmen, A., Gaut, J. P., Gehlenborg, N., Phillips, C. L., El-Achkar, T. M., Dagher, P. C., Hato, T., Zhang, K., Himmelfarb, J., Kretzler, M., Mollah, S., Lake, B., Morales, A., Stillman, I., Lecker, S., Bogen, S., Verma, A., Yu, G., Schmidt, I., Henderson, J., Beck, L., Yadati, P., Waikar, S., Amodu, A. A., Maikhor, S., Ilori, T., Colona, M. R., Weins, A., McMahon, G., Hacohen, N., Greka, A., Marshall, J. L., Hoover, P. J., Viswanathan, V. S., Crawford, D., Aulisio, M., Bush, W., Chen, Y., Madabhushi, A., O’Malley, C., Gadegbeku, C., Sendrey, D., Poggio, E., O’Toole, J., Sedor, J., Taliercio, J., Bush, L., Herlitz, L., Palmer, E., Nguyen, J., Spates-Harden, K., Cooperman, L., Jolly, S., Vinovskis, C., Bomback, A., Barasch, J., Kiryluk, K., Appelbaum, P., D’Agati, V., Berrouet, C., Mehl, K., Sabatello, M., Shang, N., Balderes, O., Canetta, P. A., Kudose, S., de Pinho Gonçalves, J., Migas, L., Van de Plas, R., Lardenoije, R., Barisoni, L., Rennke, H., Verdoes, A., Sabo, A., Gisch, D. L., Williams, J., Kelly, K., Dunn, K., Eadon, M., Ferkowicz, M., Dagher, P., Winfree, S., Bledsoe, S., Wofford, S., (El-Achkar), T. A., Sutton, T., Bowen, W., Slade, A., Record, E., Cheng, Y., Jain, Y., Herr, B., Quardokus, E., Wang, A., Villalobos, C. P. C., Parikh, C., Atta, M., Menez, S., Wen, Y., Xu, A., Bernard, L., Johansen, C., Chen, S., Rosas, S., Donohoe, I., Sun, J., Knight, R., Shpigel, A., Bebiak, J., Saul, J., Ardayfio, J., Koewler, R., Pinkeney, R., Campbell, T., Azeloglu, E., Nadkarni, G., He, J., Tokita, J., Campbell, K., Patel, M., Lefferts, S., Iyengar, S. R., Ward, S., Coca, S., He, C., Xiong, Y., Prasad, P., Rovin, B., Shapiro, J. P., Parikh, S., Madhavan, S. M., Lukowski, J., Velickovic, D., Pasa-Tolic, L., Oliver, G., Troyanskaya, O., Sealfon, R., Mao, W., Wong, A., Pollack, A., Goltsev, Y., Ginley, B., Lutnick, B., Nolan, G., Anjani, K., Mukatash, T., Laszik, Z. G., Campos, B., Thajudeen, B., Beyda, D., Bracamonte, E., Brosius, F., Woodhead, G., Mendoza, K., Marquez, N., Scott, R., Tsosie, R., Saunders, M., Rike, A., Woodle, E. S., Lee, P. J., Alloway, R. R., Shi, T., Hsieh, E., Kendrick, J., Thurman, J., Wrobel, J., Pyle, L., Bjornstad, P., Lucarelli, N., Sarder, P., Renteria, A., Ricardo, A., Srivastava, A., Redmond, D., Carmona-Powell, E., Bui, J., Lash, J., Fox, M., Meza, N., Gaba, R., Setty, S., Kelly, T., Lienczewski, C., Demeke, D., Otto, E., Ascani, H., Hodgin, J., Schaub, J., Hartman, J., Mariani, L., Bitzer, M., Rose, M., Bonevich, N., Conser, N., McCown, P., Dull, R., Menon, R., Reamy, R., Eddy, S., Balis, U., Blanc, V., Nair, V., He, Y. O., Wright, Z., Steck, B., Luo, J., Frey, R., Coleman, A., Henderson-Brown, D., Berge, J., Caramori, M. L., Adeyi, O., Nachman, P., Safadi, S., Flanagan, S., Ma, S., Klett, S., Wolf, S., Harindhanavudhi, T., Rao, V., Mottl, A., Froment, A., Zeitler, E., Bream, P., Kelley, S., Rosengart, M., Elder, M., Palevsky, P., Murugan, R., Hall, D. E., Bender, F., Winters, J., Kellum, J. A., Gilliam, M., Tublin, M., Tan, R., Zhang, G., Sharma, K., Venkatachalam, M., Hendricks, A., Kermani, A., Torrealba, J., Vazquez, M., Wang, N., Cai, Q., Miller, R. T., Ma, S., Hedayati, S., Hoofnagle, A., Wangperawong, A., Berglund, A., Dighe, A. L., Young, B., Larson, B., Berry, B., Alpers, C., Limonte, C., Stutzke, C., Roberts, G., de Boer, I., Snyder, J., Phuong, J., Carson, J., Rezaei, K., Tuttle, K., Brown, K., Blank, K., Sarkisova, N., Jefferson, N., McClelland, R., Mooney, S., Nam, Y., Wilcox, A., Park, C., Dowd, F., Williams, K., Grewenow, S. M., Daniel, S., Shankland, S., Pamreddy, A., Ye, H., Montellano, R., Bansal, S., Pillai, A., Zhang, D., Park, H., Patel, J., Sambandam, K., Basit, M., Wen, N., Moe, O. W., Toto, R. D., Lee, S. C., Sharman, K., Caprioli, R. M., Fogo, A., Allen, J., Spraggins, J., Djambazova, K., de Caestecker, M., Dufresne, M., Farrow, M., Vijayan, A., Minor, B., Nwanne, G., Gaut, J., Conlon, K., Kaushal, M., Diettman, S. M., Victoria Castro, A. M., Moledina, D., Wilson, F. P., Moeckel, G., Cantley, L., Shaw, M., Kakade, V., Arora, T., Jain, S., Rauchman, M. & Eadon, M. T., Dec 2024, In: Nature communications. 15, 1, 433.

      Research output: Contribution to journalArticlepeer-review

      Open Access
      1 Scopus citations
    • Aberrant centrosome biogenesis disrupts nephron and collecting duct progenitor growth and fate resulting in fibrocystic kidney disease

      Cheng, T., Agwu, C., Shim, K., Wang, B., Jain, S. & Mahjoub, M. R., Dec 2023, In: Development (Cambridge). 150, 24

      Research output: Contribution to journalArticlepeer-review

      Open Access
      1 Scopus citations