• 4304 Citations
1990 …2020

Research output per year

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Personal profile

Research interests

Our overall interest is to delineate molecular signals that regulate organogenesis and determine their role in injury and regeneration. We use glial cell line-derived neurotrophic factor (GDNF) family ligands-Ret receptor tyrosine kinase signaling system as a paradigm. This signaling system is associated with a number of human diseases including developmental abnormalities, neurodegenerative diseases and cancer syndromes. Using genetically defined Ret signaling mutants we have identified molecular basis for signaling specificity in the development of urogenital system and currently extending these to peripheral and central nervous system. Our future goals are to understand the role of Ret signaling in self-renewal after injury, determine roles and mechanisms of GFLs in therapy, use bioinformatics and genomic approaches to identify downstream signaling molecules that mediate Ret's pathological effects and translate these discoveries into humans.

Keywords

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Research Output

Single cell transcriptomics identifies focal segmental glomerulosclerosis remission endothelial biomarker

Kidney Precision Medicine Project (KPMP),5 and Nephrotic Syndrome Study Network (NEPTUNE), Mar 26 2020, In : JCI Insight. 5, 6, e133267.

Research output: Contribution to journalArticle

Open Access
  • 1 Scopus citations

    An integrated iterative annotation technique for easing neural network training in medical image analysis

    Lutnick, B., Ginley, B., Govind, D., McGarry, S. D., LaViolette, P. S., Yacoub, R., Jain, S., Tomaszewski, J. E., Jen, K. Y. & Sarder, P., Feb 1 2019, In : Nature Machine Intelligence. 1, 2, p. 112-119 8 p.

    Research output: Contribution to journalArticle

  • A single-nucleus RNA-sequencing pipeline to decipher the molecular anatomy and pathophysiology of human kidneys

    Lake, B. B., Chen, S., Hoshi, M., Plongthongkum, N., Salamon, D., Knoten, A., Vijayan, A., Venkatesh, R., Kim, E. H., Gao, D., Gaut, J., Zhang, K. & Jain, S., Dec 1 2019, In : Nature communications. 10, 1, 2832.

    Research output: Contribution to journalArticle

    Open Access
  • 12 Scopus citations

    A toolbox to characterize human induced pluripotent stem cell-derived kidney cell types and organoids

    Vanslambrouck, J. M., Wilson, S. B., Tan, K. S., Soo, J. Y. C., Scurr, M., Spijker, H. S., Starks, L. T., Neilson, A., Cui, X., Jain, S., Little, M. H. & Howden, S. E., 2019, In : Journal of the American Society of Nephrology. 30, 10, p. 1811-1823 13 p.

    Research output: Contribution to journalArticle

  • 4 Scopus citations

    Computational segmentation and classification of diabetic glomerulosclerosis

    Ginley, B., Lutnick, B., Jen, K. Y., Fogo, A. B., Jain, S., Rosenberg, A., Walavalkar, V., Wilding, G., Tomaszewski, J. E., Yacoub, R., Rossi, G. M. & Sarder, P., 2019, In : Journal of the American Society of Nephrology. 30, 10, p. 1953-1967 15 p.

    Research output: Contribution to journalArticle

  • 12 Scopus citations