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Personal profile

Research interests

Natural killer (NK) cells play a critical role in host immune responses against viruses and cancer. Numerous mechanisms control NK cell function, including activation receptor mediated NK cell tolerance. Continuous engagement of activating receptors on human and mouse NK cells induces tolerance in NK cells and appears to alter how NK cells respond to tumor cells. A significant gap exists in our understanding of how continuous activating receptor engagement results in NK cell tolerance and the role this plays in the NK cell immune response. Using an NK cell specific mouse model, we are interested in studying the mechanism by which activation receptor mediated NK cell tolerance occurs. As activating receptors from both human and murine NK cells signal through similar pathways, information gained from our studies regarding the underlying mechanism(s) of how continuous engagement of activating receptors results in NK cell defects is applicable to human NK cells.

Areas of Clinical Interest


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Research Output

  • 1421 Citations
  • 13 Article
  • 1 Chapter
  • 1 Review article
Open Access
  • 1 Scopus citations

    Polymicrobial sepsis influences NK-cell-mediated immunity by diminishing NK-cell-intrinsic receptor-mediated effector responses to viral ligands or infections

    Jensen, I. J., Winborn, C. S., Fosdick, M. G., Shao, P., Tremblay, M. M., Shan, Q., Tripathy, S. K., Snyder, C. M., Xue, H. H., Griffith, T. S., Houtman, J. C. & Badovinac, V. P., Oct 2018, In : PLoS pathogens. 14, 10, e1007405.

    Research output: Contribution to journalArticle

    Open Access
  • 11 Scopus citations

    Expression of the inhibitory receptor NKG2A correlates with increased liver and splenic NK cell response to activating receptor engagement

    Meyer, C. E., Key, P. N., Zhu, T., Shabsovich, M., Ni, A. & Tripathy, S. K., 2017, In : Immunity Inflammation and Disease. 5, 2, p. 177-189 13 p.

    Research output: Contribution to journalArticle

    Open Access
  • 2 Scopus citations

    Acquisition of activation receptor ligand by trogocytosis renders NK cells hyporesponsive

    Miner, C. A., Giri, T. K., Meyer, C. E., Shabsovich, M. & Tripathy, S. K., Feb 15 2015, In : Journal of Immunology. 194, 4, p. 1945-1953 9 p.

    Research output: Contribution to journalArticle

    Open Access
  • 17 Scopus citations

    Viral infection transiently reverses activation receptor-mediated NK cell hyporesponsiveness in an MHC class I-independent mechanism

    Mazumdar, B., Bolanos, F. D. & Tripathy, S. K., Apr 2013, In : European Journal of Immunology. 43, 5, p. 1345-1355 11 p.

    Research output: Contribution to journalArticle

  • 5 Scopus citations