Research output per year
Research output per year
Personal profile
Research interests
The Karam Laboratory is a tumor immunology lab focused basic and translational approaches to understanding how radiation contributes to response and resistance to immunotherapy, locally, regionally, and systemically. We utilize various in vivo models and human trial specimens, to understand the immune effects within the micro- and macro- environments. Current ongoing projects include:
- Tregs-HEV interaction in mediating local and regional immunity in HNSCC
- Dichotomous effects of Eph-ephrin interaction on the immune HNSCC
- Role of estrogen and in mediating response to immune checkpoint blockade in HNSCC and pancreatic cancer
- Effects of radiation dose and fractionation on systemic immunity and distant metastasis
- Dissecting sensory-neuro immune interaction in mediating resistance to radioimmunotherapy
- Overinflammation and disease hyperprogression in the context of combination radiation and checkpoint blockade
- Biomarker development of response to radioimmunotherapy in HNSCC and PDAC cancers
Currently accepting PhD and MSTP students
Clinical interests
Head and neck cancer, pancreatic cancer, recurrent/metastatic disease, immunotherapy combinations with radiation
Available to Mentor:
- PhD/MSTP Students
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Divergent response to radio-immunotherapy is defined by intrinsic features of the tumor microenvironment
Gadwa, J., Yu, J., Piper, M., Knitz, M. W., Darragh, L. B., Olimpo, N., Corbo, S., Beynor, J. I., Neupert, B., Nguyen, A. T., Hodgson, C., Nguyen, D., Abdelazeem, K. N. M., Saviola, A., Pousse, L., Bransi, A., Pincha, M., Klein, C., Amann, M. & Karam, S. D., Jan 7 2025, In: Journal for ImmunoTherapy of Cancer. 13, 1, e010405.Research output: Contribution to journal › Article › peer-review
Open Access -
MHC class I upregulation contributes to the therapeutic response to radiotherapy in combination with anti-PD-L1/anti-TGF-β in squamous cell carcinomas with enhanced CD8 T cell memory-driven response
Lind, H. T., Hall, S. C., Strait, A. A., Goon, J. B., Aleman, J. D., Chen, S. M. Y., Karam, S. D., Young, C. D., Wang, J. H. & Wang, X. J., Jan 1 2025, In: Cancer Letters. 608, 217347.Research output: Contribution to journal › Article › peer-review
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Proceedings of the National Cancer Institute Workshop on combining immunotherapy with radiotherapy: challenges and opportunities for clinical translation
Morris, Z. S., Demaria, S., Monjazeb, A. M., Formenti, S. C., Weichselbaum, R. R., Welsh, J., Enderling, H., Schoenfeld, J. D., Brody, J. D., McGee, H. M., Mondini, M., Kent, M. S., Young, K. H., Galluzzi, L., Karam, S. D., Theelen, W. S. M. E., Chang, J. Y., Huynh, M. A., Daib, A. & Pitroda, S. & 28 others, , Mar 2025, In: The Lancet Oncology. 26, 3, p. e152-e170Research output: Contribution to journal › Review article › peer-review
1 Scopus citations -
Pushing the boundaries of radiotherapy-immunotherapy combinations: highlights from the 7th immunorad conference
Laurent, P. A., André, F., Bobard, A., Deandreis, D., Demaria, S., Depil, S., Eichmüller, S. B., Fernandez-Palomo, C., Foijer, F., Galluzzi, L., Galon, J., Guckenberger, M., Harrington, K. J., Herrera, F. G., Huber, P. E., Italiano, A., Karam, S. D., Kroemer, G., Lambin, P. & Leuschner, C. & 14 others, , 2025, In: OncoImmunology. 14, 1, 2432726.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
The Use of Virtual Reality for 3D Diagnostic Imaging Review Enhances Understanding and Education of Patients with Cancer
Holt, D. E., Carr, A. L., Roberts, S., Milgrom, S. A., Kolva, E., Kavanagh, B. D., Switzer, G. E., Eitel, C., Nelson, J., Miller, B., Shiao, J., Mueller, A. C., Karam, S. D. & Clapp, T. R., 2025, (Accepted/In press) In: International Journal of Radiation Oncology Biology Physics.Research output: Contribution to journal › Article › peer-review