Personal profile
Research interests
Dr. Klein’s research involves the use of stable isotope tracers to study substrate metabolism in human subjects. His major research interest involves learning how obesity contributes to metabolic disease. His work has increased the understanding of normal adipose tissue physiology, the alterations in fat metabolism associated with obesity and fatty liver disease, and how weight loss improves the metabolic problems caused by obesity. He is also involved in conducting clinical trials to evaluate the safety and efficacy of obesity therapies.
Clinical interests
Obesity, nutrition, weight management, gastroenterology, metabolism
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Collaborations and top research areas from the last five years
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Clinical Trial: Semaglutide Versus Placebo in NIT-Assessed MASH—A Multicenter Randomised Placebo-Controlled Trial (SAMARA)
Ajmera, V., Vuppalanchi, R., Khalili, M., Sheikh, M. Y., Risser, J., Klein, S., Tincopa, M., Madamba, E., Singh, S., Siddiqi, H., Cortez-Moreno, D., Contrano, D., Hofflich, H., Abeles, R., Lunde, O., Grunvald, E., Bettencourt, R., He, F., Jain, S. & Richards, L. & 1 others, , Apr 2026, In: Alimentary Pharmacology and Therapeutics. 63, 8, p. 1080-1088 9 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Link opens in a new tab Scopus citations -
Effect of a Pregnancy Lifestyle Intervention Embedded Into a Home Visiting Program on Child Neurodevelopment
Farabi, S. S., Bass, R., Mathur, A., Schwarz, C., Woolfolk, C., Stein, R., Klein, S., Haire-Joshu, D. & Cahill, A. G., 2026, In: Journal of Nutrition and Metabolism. 2026, 1, 5518243.Research output: Contribution to journal › Article › peer-review
Open Access -
Effects of Marked Weight Loss Induced by Gastric Bypass Surgery or Low-Calorie Diet Alone on Postprandial Glucose Disposal in Type 2 Diabetes
Mittendorfer, B., Patterson, B. W., Eagon, J. C., Yoshino, M. & Klein, S., Feb 2026, In: Diabetes. 75, 2, p. 264-272 9 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Immune cells regulate circulating adipocyte extracellular vesicle levels in response to metabolic shifts
Tiash, S., Patel, S. A., Russo, M., Suresh, A., Pang, B., Pai, Y. L., Jia, W., Field, R. L., Pietka, T., Abumrad, N. A., Smith, G. I., Samovski, D., Klein, S., Brestoff, J. R. & Crewe, C., May 5 2026, In: Cell metabolism. 38, 5, p. 929-943.e8Research output: Contribution to journal › Article › peer-review
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Influence of obesity and insulin resistance with hepatic steatosis on the human plasma lipidome
Petersen, M. C., Smith, G. I., Armando, A. M., Su, X., Quehenberger, O., Dennis, E. A. & Klein, S., Jan 2026, In: Journal of lipid research. 67, 1, 100969.Research output: Contribution to journal › Article › peer-review
Open Access