Samuel Klein

Danforth Professor of Medicine, Professor of Cell Biology and Physiology

    • 39405 Citations
    1977 …2020

    Research output per year

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    Personal profile

    Research interests

    Dr. Klein’s research involves the use of stable isotope tracers to study substrate metabolism in human subjects. His major research interest involves learning how obesity contributes to metabolic disease. His work has increased the understanding of normal adipose tissue physiology, the alterations in fat metabolism associated with obesity and fatty liver disease, and how weight loss improves the metabolic problems caused by obesity. He is also involved in conducting clinical trials to evaluate the safety and efficacy of obesity therapies.

    Areas of Clinical Interest

    Obesity, nutrition, weight management, gastroenterology, metabolism

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    Research Output

    A word of caution against excessive protein intake

    Mittendorfer, B., Klein, S. & Fontana, L., Jan 1 2020, In : Nature Reviews Endocrinology. 16, 1, p. 59-66 8 p.

    Research output: Contribution to journalArticle

  • 3 Scopus citations

    Effects of Diet versus Gastric Bypass on Metabolic Function in Diabetes

    Yoshino, M., Kayser, B. D., Yoshino, J., Stein, R. I., Reeds, D., Eagon, C., Eckhouse, S. R., Watrous, J. D., Jain, M., Knight, R., Schechtman, K., Patterson, B. W. & Klein, S., Aug 20 2020, In : New England Journal of Medicine. 383, 8, p. 721-732 12 p.

    Research output: Contribution to journalArticle

  • 2 Scopus citations

    Influence of adiposity, insulin resistance, and intrahepatic triglyceride content on insulin kinetics

    Smith, G. I., Polidori, D. C., Yoshino, M., Kearney, M. L., Patterson, B. W., Mittendorfer, B. & Klein, S., Jun 1 2020, In : Journal of Clinical Investigation. 130, 6, p. 3305-3314 10 p.

    Research output: Contribution to journalArticle

    Open Access
  • Insulin resistance drives hepatic de novo lipogenesis in nonalcoholic fatty liver disease

    Smith, G. I., Shankaran, M., Yoshino, M., Schweitzer, G. G., Chondronikola, M., Beals, J. W., Okunade, A. L., Patterson, B. W., Nyangau, E., Field, T., Sirlin, C. B., Talukdar, S., Hellerstein, M. K. & Klein, S., Mar 2 2020, In : Journal of Clinical Investigation. 130, 3, p. 1453-1460 8 p.

    Research output: Contribution to journalArticle

    Open Access
  • 15 Scopus citations