Research output per year
Research output per year
Personal profile
Research interests
My research is focused on two issues: animal aging and zinc biology. We use the model organism C. elegans to identify drugs and genes that influence longevity. We are particularly interested in the age-related degeneration of specific tissues, such as the female reproductive system. Zinc is an essential nutrient in animals, and we are investigating how animals maintain zinc homeostasis in the face of variable dietary levels.
Available to Mentor:
- PhD/MSTP Students
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Collaborations and top research areas from the last five years
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Lysosome-related organelles contain an expansion compartment that mediates delivery of zinc transporters to promote homeostasis
Mendoza, A. D., Dietrich, N., Tan, C. H., Herrera, D., Kasiah, J., Payne, Z., Cubillas, C., Schneider, D. L. & Kornfeld, K., Feb 13 2024, In: Proceedings of the National Academy of Sciences of the United States of America. 121, 7, e2307143121.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
The ACE inhibitor captopril inhibits ACN-1 to control dauer formation and aging
Egan, B. M., Pohl, F., Anderson, X., Williams, S. C., Adodo, I. G., Hunt, P., Wang, Z., Chiu, C. H., Scharf, A., Mosley, M., Kumar, S., Schneider, D. L., Fujiwara, H., Hsu, F. F. & Kornfeld, K., 2024, In: Development (Cambridge). 151, 3, p. 1-16 16 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
UNC-49 is a redox-sensitive GABAA receptor that regulates the mitochondrial unfolded protein response cell nonautonomously
Pohl, F., Germann, A. L., Mao, J., Hou, S., Bakare, B., Lin, P. K. T., Yates, K., Nonet, M. L., Akk, G., Kornfeld, K. & Held, J. M., Nov 2023, In: Science Advances. 9, 44, eadh2584.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
A laboratory and simulation platform to integrate individual life history traits and population dynamics
Scharf, A., Mitteldorf, J., Armstead, B., Schneider, D., Jin, H., Kocsisova, Z., Tan, C. H., Sanchez, F., Brady, B., Ram, N., DiAntonio, G. B., Wilson, A. M. & Kornfeld, K., Feb 2022, In: Nature Computational Science. 2, 2, p. 90-101 12 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Control of aging by the renin–angiotensin system: a review of C. elegans, Drosophila, and mammals
Egan, B. M., Scharf, A., Pohl, F. & Kornfeld, K., Sep 14 2022, In: Frontiers in Pharmacology. 13, 938650.Research output: Contribution to journal › Review article › peer-review
Open Access6 Scopus citations