Ruijin Lu

2025

Associations of Cerebrospinal Fluid Orexin-A, Alzheimer Disease Biomarkers, and Cognitive Performance

Lu, R., Shah, K., Toedebusch, C. D., Hess, A., Richardson, R., Mignot, E., Schindler, S. E., Benzinger, T. L. S., Flores, S., Hassenstab, J., Xiong, C., Morris, J. C., Holtzman, D. M. & Lucey, B. P., Apr 2025, In: Annals of Clinical and Translational Neurology. 12, 4, p. 780-791 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Longitudinal analysis of a dominantly inherited Alzheimer disease mutation carrier protected from dementia

on behalf of the Dominantly Inherited Alzheimer Network, Apr 2025, In: Nature medicine. 31, 4, p. 1267-1275 9 p., 1711.e15.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

2024

A Variance-Based Sensitivity Analysis Approach for Identifying Interactive Exposures

Lu, R., Zhang, B., Birukov, A., Zhang, C. & Chen, Z., Jul 2024, In: Statistics in Biosciences. 16, 2, p. 520-541 22 p.

Research output: Contribution to journal › Article › peer-review

Comparative neurofilament light chain trajectories in CSF and plasma in autosomal dominant Alzheimer’s disease

Dominantly Inherited Alzheimer Network, Dec 2024, In: Nature communications. 15, 1, 9982.

Research output: Contribution to journal › Article › peer-review

Open Access

Comparison of tau spread in people with Down syndrome versus autosomal-dominant Alzheimer's disease: a cross-sectional study

Alzheimer's Biomarker Consortium–Down Syndrome, Dominantly Inherited Alzheimer Network, Wisch, J. K., McKay, N. S., Boerwinkle, A. H., Kennedy, J., Flores, S., Handen, B. L., Christian, B. T., Head, E., Mapstone, M., Rafii, M. S., O'Bryant, S. E., Price, J. C., Laymon, C. M., Krinsky-McHale, S. J., Lai, F., Rosas, H. D., Hartley, S. L. & Zaman, S. & 152 others, Lott, I. T., Tudorascu, D., Zammit, M., Brickman, A. M., Lee, J. H., Bird, T. D., Cohen, A., Chrem, P., Daniels, A., Chhatwal, J. P., Cruchaga, C., Ibanez, L., Jucker, M., Karch, C. M., Day, G. S., Lee, J. H., Levin, J., Llibre-Guerra, J., Li, Y., Lopera, F., Roh, J. H., Ringman, J. M., Supnet-Bell, C., van Dyck, C. H., Xiong, C., Wang, G., Morris, J. C., McDade, E., Bateman, R. J., Benzinger, T. L. S., Gordon, B. A., Ances, B. M., Aizenstein, H. J., Andrews, H. F., Bell, K., Birn, R. M., Bulova, P., Cheema, A., Chen, K., Clare, I., Clark, L., Cohen, A. D., Constantino, J. N., Doran, E. W., Feingold, E., Foroud, T. M., Hartley, S. L., Hom, C., Honig, L., Ikonomovic, M. D., Johnson, S. C., Jordan, C., Kamboh, M. I., Keator, D., Klunk, W. E., Kofler, J. K., Kreisl, W. C., Krinsky-McHale, S. J., Lao, P., Laymon, C., Lott, I. T., Lupson, V., Mathis, C. A., Minhas, D. S., Nadkarni, N., Pang, D., Petersen, M., Price, J. C., Pulsifer, M., Reiman, E., Rizvi, B., Sabbagh, M. N., Schupf, N., Tudorascu, D. L., Tumuluru, R., Tycko, B., Varadarajan, B., White, D. A., Yassa, M. A., Zhang, F., Bateman, R., Daniels, A., Courtney, L., Llibre-Guerra, J., Xiong, C., Xu, X., Lu, R., Gremminger, E., Perrin, R. J., Franklin, E., Jerome, G., Herries, E., Stauber, J., Baker, B., Minton, M., Goate, A. M., Renton, A. E., Picarello, D. M., Benzinger, T., Gordon, B. A., Hornbeck, R., Hassenstab, J., Smith, J., Stout, S., Aschenbrenner, A. J., Karch, C. M., Marsh, J., Morris, J. C., Holtzman, D. M., Barthelemy, N., Xu, J., Noble, J. M., Berman, S. B., Ikonomovic, S., Nadkarni, N. K., Day, G., Graff-Radford, N. R., Farlow, M., Chhatwal, J. P., Ikeuchi, T., Kasuga, K., Niimi, Y., Huey, E. D., Salloway, S., Schofield, P. R., Brooks, W. S., Bechara, J. A., Martins, R., Fox, N. C., Cash, D. M., Ryan, N. S., Laske, C., Hofmann, A., Kuder-Buletta, E., Graber-Sultan, S., Obermueller, U., Roedenbeck, Y., Vöglein, J., Sanchez-Valle, R., Rosa-Neto, P., Allegri, R. F., Chrem Mendez, P., Surace, E., Vazquez, S., Leon, Y. M., Ramirez, L., Aguillon, D., Levey, A. I., Johnson, E. C. B., Seyfried, N. T., Ringman, J. & Mori, H., May 2024, In: The Lancet Neurology. 23, 5, p. 500-510 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

Correlational analyses of biomarkers that are harmonized through a bridging study due to measurement errors

Xiong, C., Schindler, S. E., Henson, R. L., Wolk, D. A., Shaw, L. M., Agboola, F., Morris, J. C., Lu, R. & Luo, J., Feb 2024, In: Statistical Methods in Medical Research. 33, 2, p. 185-202 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

CSF proteomics identifies early changes in autosomal dominant Alzheimer's disease

Dominantly Inherited Alzheimer Network, Oct 31 2024, In: Cell. 187, 22, p. 6309-6326.e15

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Deconstructing pathological tau by biological process in early stages of Alzheimer disease: a method for quantifying tau spatial spread in neuroimaging

the Dominantly Inherited Alzheimer Network (DIAN) Investigators, Doering, S., McCullough, A., Gordon, B. A., Chen, C. D., McKay, N., Hobbs, D., Keefe, S., Flores, S., Scott, J., Smith, H., Jarman, S., Jackson, K., Hornbeck, R. C., Ances, B. M., Xiong, C., Aschenbrenner, A. J., Hassenstab, J., Cruchaga, C. & Daniels, A. & 104 others, Bateman, R. J., Noble, J. M., Day, G. S., Graff-Radford, N. R., Voglein, J., Levin, J., Allegri, R. F., Mendez, P. C., Surace, E., Berman, S. B., Ikonomovic, S., Nadkarni, N. K., Lopera, F., Ramirez, L., Aguillon, D., Leon, Y., Ramos, C., Alzate, D., Baena, A., Londono, N., Moreno, S., Jucker, M., Laske, C., Kuder-Buletta, E., Graber-Sultan, S., Preische, O., Hofmann, A., Ikeuchi, T., Kasuga, K., Niimi, Y., Ishii, K., Senda, M., Sanchez-Valle, R., Rosa-Neto, P., Fox, N. C., Cash, D., Lee, J. H., Roh, J. H., Salloway, S., Riddle, M. C., Menard, W., Bodge, C., Surti, M., Takada, L. T., Farlow, M., Chhatwal, J. P., Sanchez-Gonzalez, V. J., Orozco-Barajas, M., Goate, A. M., Renton, A. E., Esposito, B. T., Karch, C. M., Marsh, J., Fernanadez, V., Fagan, A. M., Jerome, G., Herries, E., Llibre-Guerra, J., Levey, A. I., Johnson, E. C. B., Seyfried, N. T., Schofield, P. R., Brooks, W. S., Bechara, J. A., Bateman, R., McDade, E., Perrin, R. J., Franklin, E. E., Benzinger, T., Chen, A., Chen, C., Friedrichsen, N., Gordon, B., Hantler, N., Hornbeck, R., Jarman, S., Koudelis, D., Massoumzadeh, P., Nicklaus, J., Pulizos, C., Wang, Q., Mishall, S., Sabaredzovic, E., Deng, E., Candela, M., Wang, P., Xu, X., Li, Y., Gremminger, E., Ma, Y., Bui, R., Lu, R., Martins, R., Sosa Ortiz, A. L., Courtney, L., Mori, H., Supnet-Bell, C., Xu, J., Ringman, J., Barthelemy, N., Morris, J., Smith, J., Morris, J. C. & Benzinger, T. L. S., May 2024, In: EBioMedicine. 103, 105080.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Healthy dietary patterns are associated with exposure to environmental chemicals in a pregnancy cohort

Yu, G., Lu, R., Yang, J., Rahman, M. L., Li, L. J., Wang, D. D., Sun, Q., Pang, W. W., Guivarch, C., Birukov, A., Grewal, J., Chen, Z. & Zhang, C., Jul 2024, In: Nature Food. 5, 7, p. 563-568 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Maternal plasma phospholipid polyunsaturated fatty acids in early pregnancy and thyroid function throughout pregnancy: a longitudinal study

Li, L. J., Lu, R., Rawal, S., Birukov, A., Weir, N. L., Tsai, M. Y., Wu, J., Chen, Z. & Zhang, C., Apr 2024, In: American Journal of Clinical Nutrition. 119, 4, p. 1065-1074 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Physical Activity and High-Sensitivity C-Reactive Protein in Pregnancy: Does It Matter during Leisure or Work?

Liu, X., Chen, L., Li, J., Holtermann, A., Lu, R., Birukov, A., Weir, N. L., Tsai, M. Y. & Zhang, C., Jan 1 2024, In: Medicine and Science in Sports and Exercise. 56, 1, p. 110-117 8 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Presenilin-1 mutation position influences amyloidosis, small vessel disease, and dementia with disease stage

Joseph-Mathurin, N., Feldman, R. L., Lu, R., Shirzadi, Z., Toomer, C., Saint Clair, J. R., Ma, Y., McKay, N. S., Strain, J. F., Kilgore, C., Friedrichsen, K. A., Chen, C. D., Gordon, B. A., Chen, G., Hornbeck, R. C., Massoumzadeh, P., McCullough, A. A., Wang, Q., Li, Y. & Wang, G. & 38 others, Keefe, S. J., Schultz, S. A., Cruchaga, C., Preboske, G. M., Jack, C. R., Llibre-Guerra, J. J., Allegri, R. F., Ances, B. M., Berman, S. B., Brooks, W. S., Cash, D. M., Day, G. S., Fox, N. C., Fulham, M., Ghetti, B., Johnson, K. A., Jucker, M., Klunk, W. E., la Fougère, C., Levin, J., Niimi, Y., Oh, H., Perrin, R. J., Reischl, G., Ringman, J. M., Saykin, A. J., Schofield, P. R., Su, Y., Supnet-Bell, C., Vöglein, J., Yakushev, I., Brickman, A. M., Morris, J. C., McDade, E., Xiong, C., Bateman, R. J., Chhatwal, J. P. & Benzinger, T. L. S., Apr 2024, In: Alzheimer's and Dementia. 20, 4, p. 2680-2697 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Relationships of Cognitive Measures with Cerebrospinal Fluid but Not Imaging Biomarkers of Alzheimer Disease Vary between Black and White Individuals

Bonomi, S., Lu, R., Schindler, S. E., Bui, Q., Lah, J. J., Wolk, D., Gleason, C. E., Sperling, R., Roberson, E. D., Levey, A. I., Shaw, L., Van Hulle, C., Benzinger, T., Adams, M., Manzanares, C., Qiu, D., Hassenstab, J., Moulder, K. L., Balls-Berry, J. E. & Johnson, K. & 16 others, Johnson, S. C., Murchison, C. F., Luo, J., Gremminger, E., Agboola, F., Grant, E. A., Hornbeck, R., Massoumzadeh, P., Keefe, S., Dierker, D., Gray, J., Henson, R. L., Streitz, M., Mechanic-Hamilton, D., Morris, J. C. & Xiong, C., Mar 2024, In: Annals of neurology. 95, 3, p. 495-506 12 p.

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

γ-Secretase activity, clinical features, and biomarkers of autosomal dominant Alzheimer's disease: cross-sectional and longitudinal analysis of the Dominantly Inherited Alzheimer Network observational study (DIAN-OBS)

Dominantly Inherited Alzheimer Network, Sep 2024, In: The Lancet Neurology. 23, 9, p. 913-924 12 p.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

2023

A Perception-Augmented Hidden Markov Model for Parent–Child Relations in Families of Youth with Type 1 Diabetes

Lu, R., Nansel, T. R. & Chen, Z., Apr 2023, In: Statistics in Biosciences. 15, 1, p. 288-308 21 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Cerebrospinal fluid proteomics define the natural history of autosomal dominant Alzheimer’s disease

the Dominantly Inherited Alzheimer Network, Johnson, E. C. B., Bian, S., Haque, R. U., Carter, E. K., Watson, C. M., Gordon, B. A., Ping, L., Duong, D. M., Epstein, M. P., McDade, E., Barthélemy, N. R., Karch, C. M., Xiong, C., Cruchaga, C., Perrin, R. J., Wingo, A. P., Wingo, T. S., Chhatwal, J. P. & Day, G. S. & 120 others, Noble, J. M., Berman, S. B., Martins, R., Graff-Radford, N. R., Schofield, P. R., Ikeuchi, T., Mori, H., Levin, J., Farlow, M., Lah, J. J., Haass, C., Jucker, M., Morris, J. C., Benzinger, T. L. S., Roberts, B. R., Bateman, R. J., Fagan, A. M., Seyfried, N. T., Levey, A. I., Noble, J. M., Day, G., Graff-Radford, N. R., Voglein, J., Allegri, R., Mendez, P. C., Surace, E., Ikonomovic, S., Nadkarni, N., Lopera, F., Ramirez, L., Aguillon, D., Leon, Y., Ramos, C., Alzate, D., Baena, A., Londono, N., Moreno, S., Laske, C., Kuder-Buletta, E., Graber-Sultan, S., Preische, O., Hofmann, A., Ikeuchi, T., Kasuga, K., Niimi, Y., Ishii, K., Senda, M., Sanchez-Valle, R., Rosa-Neto, P., Fox, N., Cash, D., Lee, J. H., Roh, J. H., Riddle, M., Menard, W., Bodge, C., Surti, M., Takada, L. T., Chhatwal, J. P., Sanchez-Gonzalez, V. J., Orozco-Barajas, M., Goate, A., Renton, A., Esposito, B., Karch, C. M., Marsh, J., Cruchaga, C., Fernandez, V., Gordon, B., Fagan, A. M., Jerome, G., Herries, E., Llibre-Guerra, J., Johnson, E. C. B., Seyfried, N. T., Schofield, P. R., Brooks, W., Bechara, J., Bateman, R. J., Hassenstab, J., Perrin, R. J., Franklin, E., Benzinger, T. L. S., Chen, A., Chen, C., Flores, S., Friedrichsen, N., Hantler, N., Hornbeck, R., Jarman, S., Keefe, S., Koudelis, D., Massoumzadeh, P., McCullough, A., McKay, N., Nicklaus, J., Pulizos, C., Wang, Q., Mishall, S., Sabaredzovic, E., Deng, E., Candela, M., Smith, H., Hobbs, D., Scott, J., Levin, J., Xiong, C., Wang, P., Xu, X., Li, Y., Gremminger, E., Ma, Y., Bui, R., Lu, R., Ortiz, A. L. S., Daniels, A., Courtney, L., Supnet-Bell, C., Xu, J. & Ringman, J., Aug 2023, In: Nature medicine. 29, 8, p. 1979-1988 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

70 Scopus citations

Early Pregnancy Maternal Plasma Phospholipid Saturated Fatty Acids and Fetal Growth: Findings from a Multi-Racial/Ethnic Birth Cohort in US

Li, L. J., Du, R., Ouidir, M., Lu, R., Chen, Z., Weir, N. L., Tsai, M. Y., Albert, P. S. & Zhang, C., Aug 2023, In: Nutrients. 15, 15, 3287.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Estimating mutation rates in a Markov branching process using approximate Bayesian computation

Lu, R., Zhu, H. & Wu, X., May 21 2023, In: Journal of Theoretical Biology. 565, 111467.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Longitudinal clinical, cognitive and biomarker profiles in dominantly inherited versus sporadic early-onset Alzheimer's disease

Llibre-Guerra, J. J., Iaccarino, L., Coble, D., Edwards, L., Li, Y., Mcdade, E., Strom, A., Gordon, B., Mundada, N., Schindler, S. E., Tsoy, E., Ma, Y., Lu, R., Fagan, A. M., Benzinger, T. L. S., Soleimani-Meigooni, D., Aschenbrenner, A. J., Miller, Z., Wang, G. & Kramer, J. H. & 22 others, Hassenstab, J., Rosen, H. J., Morris, J. C., Miller, B. L., Xiong, C., Perrin, R. J., Allegri, R., Chrem, P., Surace, E., Berman, S. B., Chhatwal, J., Masters, C. L., Farlow, M. R., Jucker, M., Levin, J., Fox, N. C., Day, G., Gorno-Tempini, M. L., Boxer, A. L., La Joie, R., Rabinovici, G. D. & Bateman, R., 2023, In: Brain Communications. 5, 6, fcad280.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

Longitudinal lipidomic profiles during pregnancy and associations with neonatal anthropometry: findings from a multiracial cohort

Song, Y., Lu, R., Yu, G., Rahman, M. L., Chen, L., Zhu, Y., Tsai, M. Y., Fiehn, O., Chen, Z. & Zhang, C., Dec 2023, In: EBioMedicine. 98, 104881.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Metabolomic biomarkers of the mediterranean diet in pregnant individuals: A prospective study

Chen, L., Dai, J., Fei, Z., Liu, X., Zhu, Y., Rahman, M. L., Lu, R., Mitro, S. D., Yang, J., Hinkle, S. N., Chen, Z., Song, Y. & Zhang, C., Mar 2023, In: Clinical Nutrition. 42, 3, p. 384-393 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Plasma Amino Acids in Early Pregnancy and Midpregnancy and Their Interplay With Phospholipid Fatty Acids in Association With the Risk of Gestational Diabetes Mellitus: Results From a Longitudinal Prospective Cohort

Yang, J., Wu, J., Tekola-Ayele, F., Li, L. J., Bremer, A. A., Lu, R., Rahman, M. L., Weir, N. L., Pang, W. W., Chen, Z., Tsai, M. Y. & Zhang, C., Apr 2023, In: Diabetes care. 46, 4, p. 722-732 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

2022

Latent classifications of parental involvement in diabetes management for youth with type 1 diabetes: A randomized clinical trial

Temmen, C. D., Lu, R., Gee, B. T., Chen, Z. & Nansel, T. R., Nov 2022, In: Pediatric Diabetes. 23, 7, p. 1133-1142 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

2017

A computational model for biosonar echoes from foliage

Ming, C., Gupta, A. K., Lu, R., Zhu, H. & Müller, R., Aug 2017, In: PloS one. 12, 8, e0182824.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

Ruijin Lu

Research output

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