If you made any changes in Pure these will be visible here soon.

Personal profile

Research interests

Alterations of signal transduction pathways play a significant role in the growth and metastasis of human cancers. One of our major focuses is the Her2/neu receptor tyrosine kinase, a member of the EGFR growth factor receptor family, which is gene amplified and activated in about 20-25% of human breast cancer cases. Several drugs that target Her2/neu are used in the treatment of Her2-positive breast cancer, such as a monoclonal antibody to the extracellular portion of the receptor or small molecule kinase inhibitors, but resistance to these drugs has frequently been seen in patients. Better understanding of Her2/neu and the downstream signal transduction pathways it uses will provide improved treatment for breast cancer patients. Our lab studies signal transduction pathways in breast cancer using a variety of approaches. Proteomics is the large-scale identification and characterization of proteins and it can be used to provide deeper insights into these pathways by identifying novel proteins and sites of post-translational modifications. We have previously published a large proteomic study of Her2/neu signaling in cell lines and are currently working on performing proteomic experiments in animal models.

Clinical interests

Breast cancer, HER2 positive breast cancer, oncology, medical oncology


Dive into the research topics where Ron Bose is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
  • 1 Similar Profiles


Recent external collaboration on country/territory level. Dive into details by clicking on the dots or