Robyn Klein

2022

Corrigendum to: “IL-1 reprogramming of adult neural stem cells limits neurocognitive recovery after viral encephalitis by maintaining a proinflammatory state” [Brain Behav. Immun. 99 (2022) 383–396] (Brain Behavior and Immunity (2022) 99 (383–396), (S0889159121005869), (10.1016/j.bbi.2021.10.010))

Soung, A. L., Dave, V. A., Garber, C., Tycksen, E. D., Vollmer, L. L. & Klein, R. S., May 2022, In: Brain, Behavior, and Immunity. 102, p. 387 1 p.

Research output: Contribution to journal › Comment/debate

COVID-19 induces CNS cytokine expression and loss of hippocampal neurogenesis

Soung, A. L., Vanderheiden, A., Nordvig, A. S., Sissoko, C. A., Canoll, P., Mariani, M. B., Jiang, X., Bricker, T., Rosoklija, G. B., Arango, V., Underwood, M., Mann, J. J., Dwork, A. J., Goldman, J. E., Boon, A. C. M., Boldrini, M. & Klein, R. S., Dec 19 2022, In: Brain : a journal of neurology. 145, 12, p. 4193-4201 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

Erratum: CCR2 Signaling Restricts SARS-CoV-2 Infection (mBio (2021) 12:6 (e02749-21) DOI: 10.1128/mBio.02749-21)

Vanderheiden, A., Thomas, J., Soung, A. L., Davis-Gardner, M. E., Floyd, K., Jin, F., Cowan, D. A., Pellegrini, K., Creanga, A., Pegu, A., Derrien-Colemyn, A., Shi, P. Y., Grakoui, A., Klein, R. S., Bosinger, S. E., Kohlmeier, J. E., Menachery, V. D. & Suthar, M. S., Jun 2022, In: mBio. 13, 3

Research output: Contribution to journal › Comment/debate

How COVID-19 shaped mental health: from infection to pandemic effects

Penninx, B. W. J. H., Benros, M. E., Klein, R. S. & Vinkers, C. H., Oct 2022, In: Nature medicine. 28, 10, p. 2027-2037 11 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

7 Scopus citations

IL-1 reprogramming of adult neural stem cells limits neurocognitive recovery after viral encephalitis by maintaining a proinflammatory state

Soung, A. L., Davé, V. A., Garber, C., Tycksen, E. D., Vollmer, L. L. & Klein, R. S., Jan 2022, In: Brain, Behavior, and Immunity. 99, p. 383-396 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

Infection and inflammation: New perspectives on Alzheimer's disease

Symposium Planning Committee members, Jul 2022, In: Brain, Behavior, and Immunity - Health. 22, 100462.

Research output: Contribution to journal › Review article › peer-review

Open Access

1 Scopus citations

Mechanisms of coronavirus infectious disease 2019-related neurologic diseases

Klein, R. S., Jun 1 2022, In: Current opinion in neurology. 35, 3, p. 392-398 7 p.

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Meningeal MAIT cells maintain meningeal and brain function

Klein, R. S., Dec 2022, In: Nature immunology. 23, 12, p. 1659-1661 3 p.

Research output: Contribution to journal › Article › peer-review

Neuroinflammation and COVID-19

Vanderheiden, A. & Klein, R. S., Oct 2022, In: Current Opinion in Neurobiology. 76, 102608.

Research output: Contribution to journal › Review article › peer-review

Open Access

3 Scopus citations

Radiosynthesis and evaluation of a fluorine-18 radiotracer [¹⁸F]FS1P1 for imaging sphingosine-1-phosphate receptor 1

Qiu, L., Jiang, H., Yu, Y., Gu, J., Wang, J., Zhao, H., Huang, T., Gropler, R. J., Klein, R. S., Perlmutter, J. S. & Tu, Z., Feb 7 2022, In: Organic and Biomolecular Chemistry. 20, 5, p. 1041-1052 12 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Single-cell RNA transcriptome analysis of CNS immune cells reveals CXCL16/CXCR6 as maintenance factors for tissue-resident T cells that drive synapse elimination

Rosen, S. F., Soung, A. L., Yang, W., Ai, S., Kanmogne, M., Davé, V. A., Artyomov, M., Magee, J. A. & Klein, R. S., Dec 2022, In: Genome medicine. 14, 1, 108.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Synthesis and evaluation of highly selective quinazoline-2,4-dione ligands for sphingosine-1-phosphate receptor 2

Luo, Z., Liu, H., Yu, Y., Gropler, R. J., Klein, R. S. & Tu, Z., Feb 2022, In: RSC Medicinal Chemistry. 13, 2, p. 202-207 6 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Targeting IFN-k Signaling Promotes Recovery from Central Nervous System Autoimmunity

Manivasagam, S., Williams, J. L., Vollmer, L. L., Bollman, B., Bartleson, J. M., Ai, S., Wu, G. F. & Klein, R. S., Mar 15 2022, In: Journal of Immunology. 208, 6, p. 1341-1351 11 p.

Research output: Contribution to journal › Article › peer-review

The multitaskers of the brain: Glial responses to viral infections and associated post-infectious neurologic sequelae

Davé, V. A. & Klein, R. S., Apr 2023, In: Glia. 71, 4, p. 803-818 16 p.

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

2021

A new era in neuroimmunology

Piccio, L., Wu, G. F. & Klein, R. S., Feb 15 2021, In: Journal of Neuroimmunology. 351, 577478.

Research output: Contribution to journal › Editorial

1 Scopus citations

A single intranasal or intramuscular immunization with chimpanzee adenovirus-vectored SARS-CoV-2 vaccine protects against pneumonia in hamsters

Bricker, T. L., Darling, T. L., Hassan, A. O., Harastani, H. H., Soung, A., Jiang, X., Dai, Y. N., Zhao, H., Adams, L. J., Holtzman, M. J., Bailey, A. L., Case, J. B., Fremont, D. H., Klein, R., Diamond, M. S. & Boon, A. C. M., Jul 20 2021, In: Cell Reports. 36, 3, 109400.

Research output: Contribution to journal › Article › peer-review

Open Access

50 Scopus citations

Astrocyte interleukin-3 preps microglia

Klein, R. S., Nov 2021, In: Trends in Immunology. 42, 11, p. 937-939 3 p.

Research output: Contribution to journal › Short survey › peer-review

2 Scopus citations

CCR2 Signaling Restricts SARS-CoV-2 Infection

Vanderheiden, A., Thomas, J., Soung, A. L., Davis-Gardner, M. E., Floyd, K., Jin, F., Cowan, D. A., Pellegrini, K., Shi, P. Y., Grakoui, A., Klein, R. S., Bosinger, S. E., Kohlmeier, J. E., Menachery, V. D. & Suthar, M. S., Dec 1 2021, In: mBio. 12, 6, e02749-21.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Scopus citations

COVID-19 neuropathology at Columbia University Irving Medical Center/New York Presbyterian Hospital

Thakur, K. T., Miller, E. H., Glendinning, M. D., Al-Dalahmah, O., Banu, M. A., Boehme, A. K., Boubour, A. L., Bruce, S. S., Chong, A. M., Claassen, J., Faust, P. L., Hargus, G., Hickman, R. A., Jambawalikar, S., Khandji, A. G., Kim, C. Y., Klein, R. S., Lignelli-Dipple, A., Lin, C. C., Liu, Y., & 14 othersMiller, M. L., Moonis, G., Nordvig, A. S., Overdevest, J. B., Prust, M. L., Przedborski, S., Roth, W. H., Soung, A., Tanji, K., Teich, A. F., Agalliu, D., Uhlemann, A. C., Goldman, J. E. & Canoll, P., Sep 1 2021, In: Brain. 144, 9, p. 2696-2708 13 p.

Research output: Contribution to journal › Article › peer-review

131 Scopus citations

Decreased antiviral immune response within the central nervous system of aged mice is associated with increased lethality of West Nile virus encephalitis

Funk, K. E., Arutyunov, A. D., Desai, P., White, J. P., Soung, A. L., Rosen, S. F., Diamond, M. S. & Klein, R. S., Aug 2021, In: Aging Cell. 20, 8, e13412.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Encephalitic Arboviruses of Africa: Emergence, Clinical Presentation and Neuropathogenesis

Klein, R. S., Dec 23 2021, In: Frontiers in immunology. 12, 769942.

Research output: Contribution to journal › Review article › peer-review

Open Access

3 Scopus citations

How COVID-19 Affects the Brain

Boldrini, M., Canoll, P. D. & Klein, R. S., Jun 2021, In: JAMA psychiatry. 78, 6, p. 682-683 2 p.

Research output: Contribution to journal › Short survey › peer-review

Open Access

151 Scopus citations

Levels of circulating NS1 impact West Nile virus spread to the brain

Wessel, A. W., Dowd, K. A., Biering, S. B., Zhang, P., Edeling, M. A., Nelson, C. A., Funk, K. E., DeMaso, C. R., Klein, R. S., Smith, J. L., Cao, T. M., Kuhn, R. J., Fremont, D. H., Harris, E., Pierson, T. C. & Diamond, M. S., Oct 2021, In: Journal of virology. 95, 20, e00844-21.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Neuroprotective versus Neuroinflammatory Roles of Complement: From Development to Disease

Kanmogne, M. & Klein, R. S., Feb 2021, In: Trends in Neurosciences. 44, 2, p. 97-109 13 p.

Research output: Contribution to journal › Review article › peer-review

11 Scopus citations

PET Study of Sphingosine-1-phosphate Receptor 1 Expression in Response to S. aureus Infection

Jiang, H., Gu, J., Zhao, H., Joshi, S., Perlmutter, J. S., Gropler, R. J., Klein, R. S., Benzinger, T. L. S. & Tu, Z., 2021, In: Molecular Imaging. 2021, 9982020.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Type III Interferons: Emerging Roles in Autoimmunity

Manivasagam, S. & Klein, R. S., Nov 26 2021, In: Frontiers in immunology. 12, 764062.

Research output: Contribution to journal › Review article › peer-review

Open Access

1 Scopus citations

2020

Astrocyte-T cell crosstalk regulates region-specific neuroinflammation

Williams, J. L., Manivasagam, S., Smith, B. C., Sim, J., Vollmer, L. L., Daniels, B. P., Russell, J. H. & Klein, R. S., Jul 1 2020, In: Glia. 68, 7, p. 1361-1374 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

Encephalitic alphaviruses exploit caveola-mediated transcytosis at the blood-brain barrier for central nervous system entry

Salimi, H., Cain, M. D., Jiang, X., Roth, R. A., Beatty, W. L., Sun, C., Klimstra, W. B., Hou, J. & Klein, R. S., Jan 1 2020, In: mBio. 11, 1, e02731-19.

Research output: Contribution to journal › Article › peer-review

Open Access

21 Scopus citations

On complement, memory, and microglia

Klein, R. S., May 21 2020, In: New England Journal of Medicine. 382, 21, p. 2056-2058 3 p.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Sex differences in cancer mechanisms

Rubin, J. B., Lagas, J. S., Broestl, L., Sponagel, J., Rockwell, N., Rhee, G., Rosen, S. F., Chen, S., Klein, R. S., Imoukhuede, P. & Luo, J., Apr 15 2020, In: Biology of Sex Differences. 11, 1, 17.

Research output: Contribution to journal › Review article › peer-review

Open Access

95 Scopus citations

Synthesis and characterization of [¹²⁵I]TZ6544, a promising radioligand for investigating sphingosine-1-phosphate receptor 2

Luo, Z., Liang, Q., Liu, H., Sumit, J., Jiang, H., Klein, R. S. & Tu, Z., Sep 1 2020, In: Nuclear Medicine and Biology. 88-89, p. 52-61 10 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Therapeutic enhancement of blood-brain and blood-Tumor barriers permeability by laser interstitial thermal therapy

Salehi, A., Paturu, M. R., Patel, B., Cain, M. D., Mahlokozera, T., Yang, A. B., Lin, T. H., Leuthardt, E. C., Yano, H., Song, S. K., Klein, R. S., Schmidt, R. & Kim, A. H., Jan 1 2020, In: Neuro-Oncology Advances. 2, 1, vdaa071.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Scopus citations

Update on T cells in the virally infected brain: friends and foes

Ai, S. & Klein, R. S., Jun 1 2020, In: Current opinion in neurology. 33, 3, p. 405-412 8 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

12 Scopus citations

2019

An In Vitro Brain Endothelial Model for Studies of Cryptococcal Transmigration into the Central Nervous System

Santiago-Tirado, F. H., Klein, R. S. & Doering, T. L., Jun 2019, In: Current Protocols in Microbiology. 53, 1, e78.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

CSF1R antagonism limits local restimulation of antiviral CD8⁺ T cells during viral encephalitis

Funk, K. E. & Klein, R. S., Jan 31 2019, In: Journal of Neuroinflammation. 16, 1, 22.

Research output: Contribution to journal › Article › peer-review

Open Access

45 Scopus citations

Design, synthesis, and in vitro bioactivity evaluation of fluorine-containing analogues for sphingosine-1-phosphate 2 receptor

Luo, Z., Liu, H., Klein, R. S. & Tu, Z., Aug 15 2019, In: Bioorganic and Medicinal Chemistry. 27, 16, p. 3619-3631 13 p.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Differential in vitro infection of neural cells by astroviruses

Janowski, A. B., Klein, R. S. & Wang, D., Jul 1 2019, In: mBio. 10, 4, e01455-19.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

Disruption of the Blood-Brain Barrier During Neuroinflammatory and Neuroinfectious Diseases

Salimi, H. & Klein, R. S., 2019, Contemporary Clinical Neuroscience. Springer Nature, p. 195-234 40 p. (Contemporary Clinical Neuroscience).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Open Access

16 Scopus citations

Mechanisms of Pathogen Invasion into the Central Nervous System

Cain, M. D., Salimi, H., Diamond, M. S. & Klein, R. S., Sep 4 2019, In: Neuron. 103, 5, p. 771-783 13 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

39 Scopus citations

Neuroinflammation During RNA Viral Infections

Klein, R. S., Garber, C., Funk, K. E., Salimi, H., Soung, A., Kanmogne, M., Manivasagam, S., Agner, S. & Cain, M., Apr 26 2019, In: Annual Review of Immunology. 37, p. 73-95 23 p.

Research output: Contribution to journal › Review article › peer-review

68 Scopus citations

T cells promote microglia-mediated synaptic elimination and cognitive dysfunction during recovery from neuropathogenic flaviviruses

Garber, C., Soung, A., Vollmer, L. L., Kanmogne, M., Last, A., Brown, J. & Klein, R. S., Aug 1 2019, In: Nature neuroscience. 22, 8, p. 1276-1288 13 p.

Research output: Contribution to journal › Article › peer-review

89 Scopus citations

2018

Astrocytes decrease adult neurogenesis during virus-induced memory dysfunction via IL-1 article

Garber, C., Vasek, M. J., Vollmer, L. L., Sun, T., Jiang, X. & Klein, R. S., Feb 1 2018, In: Nature immunology. 19, 2, p. 151-161 11 p.

Research output: Contribution to journal › Article › peer-review

79 Scopus citations

Design and synthesis of pyrazolopyridine derivatives as sphingosine 1-phosphate receptor 2 ligands

Luo, Z., Yue, X., Yang, H., Liu, H., Klein, R. S. & Tu, Z., Feb 1 2018, In: Bioorganic and Medicinal Chemistry Letters. 28, 3, p. 488-496 9 p.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Erratum to: Mycobacterium tuberculosis carrying a rifampicin drug resistance mutation reprograms macrophage metabolism through cell wall lipid changes (Nature Microbiology, (2018), 3, 10, (1099-1108), 10.1038/s41564-018-0245-0)

Howard, N. C., Marin, N. D., Ahmed, M., Rosa, B. A., Martin, J., Bambouskova, M., Sergushichev, A., Loginicheva, E., Kurepina, N., Rangel-Moreno, J., Chen, L., Kreiswirth, B. N., Klein, R. S., Balada-Llasat, J. M., Torrelles, J. B., Amarasinghe, G. K., Mitreva, M., Artyomov, M. N., Hsu, F. F., Mathema, B., & 1 othersKhader, S. A., Nov 1 2018, In: Nature microbiology. 3, 11, p. 1327 1 p.

Research output: Contribution to journal › Comment/debate

Open Access

2 Scopus citations

MicroRNA signature of central nervous system-infiltrating dendritic cells in an animal model of multiple sclerosis

Hoye, M. L., Archambault, A. S., Gordon, T. M., Oetjen, L. K., Cain, M. D., Klein, R. S., Crosby, S. D., Kim, B. S., Miller, T. M. & Wu, G. F., Sep 2018, In: Immunology. 155, 1, p. 112-122 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

Mycobacterium tuberculosis carrying a rifampicin drug resistance mutation reprograms macrophage metabolism through cell wall lipid changes

Howard, N. C., Marin, N. D., Ahmed, M., Rosa, B. A., Martin, J., Bambouskova, M., Sergushichev, A., Loginicheva, E., Kurepina, N., Rangel-Moreno, J., Chen, L., Kreiswirth, B. N., Klein, R. S., Balada-Llasat, J. M., Torrelles, J. B., Amarasinghe, G. K., Mitreva, M., Artyomov, M. N., Hsu, F. F., Mathema, B., & 1 othersKhader, S. A., Oct 1 2018, In: Nature microbiology. 3, 10, p. 1099-1108 10 p.

Research output: Contribution to journal › Letter › peer-review

57 Scopus citations

Peli1 facilitates virus replication and promotes neuroinflammation during West Nile virus infection

Luo, H., Winkelmann, E. R., Zhu, S., Ru, W., Mays, E., Silvas, J. A., Vollmer, L. L., Gao, J., Peng, B. H., Bopp, N. E., Cromer, C., Shan, C., Xie, G., Li, G., Tesh, R., Popov, V. L., Shi, P. Y., Sun, S. C., Wu, P., Klein, R. S., & 4 othersTang, S. J., Zhang, W., Aguilar, P. V. & Wang, T., Nov 1 2018, In: Journal of Clinical Investigation. 128, 11, p. 4980-4991 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access