Roberto Civitelli

Sydney M and Stella H Schoenberg Professor of Medicine, Professor of Orthopaedic Surgery, Professor of Cell Biology and Physiology

    • 10409 Citations
    1983 …2020

    Research output per year

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    Personal profile

    Research interests

    The long-term goal of our research efforts is to understand the cellular and molecular basis of the bone remodeling process, and to devise mechanisms by which this balance can be modified. Our current research is focused on how bone cells function in a social context, via intercellular communication through gap junctions and direct cell-to-cell contact. Using mouse genetics and in vitro approaches, we find that recessive null or dominant negative mutations of some connexin and cadherin genes lead to skeletal developmental abnormalities, reduced bone mass and abnormalities of bone cell differentiation and function. We are using these models to test how interference with cell-cell adhesion and communication modulates bone anabolic responses to bio-pharmacologic and physical/mechanical stimuli. The ultimate goal is to identify potential new targets for maximizing bone mass acquisition and expand therapeutic potentials for demineralizing conditions, such as osteoporosis. More information on research activity can be found in the Division of Biology and Biomedical Sciences web site, under Faculty (http://dbbs.wustl.edu/dbbs/website.nsf/).

    Areas of Clinical Interest

    Diagnosis and treatment of osteoporosis, osteopenia, measurement of bone density, bone metabolism, bone disease, mineral disease, Paget's disease of bone, disorders of phosphate metabolism, hypercalcemia, hypocalcemia

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    Research Output

    ATRAID regulates the action of nitrogen-containing bisphosphonates on bone

    Surface, L. E., Burrow, D. T., Li, J., Park, J., Kumar, S., Lyu, C., Song, N., Yu, Z., Rajagopal, A., Bae, Y., Lee, B. H., Mumm, S., Gu, C. C., Baker, J. C., Mohseni, M., Sum, M., Huskey, M., Duan, S., Bijanki, V. N., Civitelli, R. & 18 others, Gardner, M. J., McAndrew, C. M., Ricci, W. M., Gurnett, C. A., Diemer, K., Wan, F., Costantino, C. L., Shannon, K. M., Raje, N., Dodson, T. B., Haber, D. A., Carette, J. E., Varadarajan, M., Brummelkamp, T. R., Birsoy, K., Sabatini, D. M., Haller, G. & Peterson, T. R., May 20 2020, In : Science translational medicine. 12, 544, eaav9166.

    Research output: Contribution to journalArticle

  • 2 Scopus citations

    Connexin 43 Is Necessary for Murine Tendon Enthesis Formation and Response to Loading

    Shen, H., Schwartz, A. G., Civitelli, R. & Thomopoulos, S., Jan 1 2020, (Accepted/In press) In : Journal of Bone and Mineral Research.

    Research output: Contribution to journalArticle

    Open Access
  • 1 Scopus citations

    Osterix-cre marks distinct subsets of CD45-and CD45+ stromal populations in extra-skeletal tumors with pro-tumorigenic characteristics

    Ricci, B., Tycksen, E., Celik, H., Belle, J. I., Fontana, F., Civitelli, R. & Faccio, R., Aug 2020, In : eLife. 9, p. 1-29 29 p., e54659.

    Research output: Contribution to journalArticle

    Open Access
  • Scientific Editing in the COVID-19 Era—Personal Vignettes from the JBMR Editors

    Hofbauer, L. C., Rivadeneira, F., Westendorf, J. J. & Civitelli, R., Jun 1 2020, In : Journal of Bone and Mineral Research. 35, 6, p. 1005-1008 4 p.

    Research output: Contribution to journalEditorial