• 3238 Citations
1994 …2020

Research output per year

If you made any changes in Pure these will be visible here soon.

Personal profile

Research interests

Excessive bone loss in rheumatoid arthritis and some bone metastasis is mostly due to an abnormal activation of the immune system leading to stimulation of osteoclasts (OCs). Our goal is to discover common signaling molecules affecting the osteo-immune system and study their impact on normal and pathological bone loss. We have identified a novel role for the immunomodulatory protein PLC?2 as central mediator of RANKL-induced osteoclastogenesis, independent of PLC?1. OCs, the principal bone resorbing cells, develop from bone marrow macrophages primarily under the influence of two major regulators: M-CSF and RANKL, and less understood costimulatory factors that act via immunoreceptor tyrosine-based activation motif (ITAM)-containing receptors on OC precursor cells. Our data indicate that targeted deletion of PLC?2 leads to an osteopetrotic phenotype due to defective OC recruitment and function. Thus, the interest of my lab is to 1) identify structural domains of PLC?2 required for OC differentiation and understand the mechanism leading to PLC?2 activation, but not PLC?1, in the bone resorbing cells; 2) examine the interaction of PLC?2 with element of the OC cytoskeleton and the avß3 integrin during bone resorption and study the role of PLC?2 in OC activation and bone erosion in vivo; 3) considering the importance of PLC?2 in regulation of B cell mediated immune responses and osteoclastogenesis, determine the relative PLC?2-dependent contribution of B and T cells in the development of inflammation and bone erosion in rheumatoid arthritis; and 4) study the role of the of PLC?2 in the progression of breast cancer induced bone metastases. These studies might unveil novel OC regulatory mechanisms and provide the basis for new antiresorptive therapies in the context of inflammatory bone loss and bone cancer metastases.

Fingerprint Dive into the research topics where Roberta Faccio is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 30 Similar Profiles

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output

Diacylglycerol kinase Z regulates macrophage responses in juvenile arthritis and cytokine Storm syndrome mouse models

Mahajan, S., Mellins, E. D. & Faccio, R., Jan 1 2020, In : Journal of Immunology. 204, 1, p. 137-146 10 p.

Research output: Contribution to journalArticle

  • 2 Scopus citations

    Osterix-cre marks distinct subsets of CD45-and CD45+ stromal populations in extra-skeletal tumors with pro-tumorigenic characteristics

    Ricci, B., Tycksen, E., Celik, H., Belle, J. I., Fontana, F., Civitelli, R. & Faccio, R., Aug 2020, In : eLife. 9, p. 1-29 29 p., e54659.

    Research output: Contribution to journalArticle

    Open Access
  • Therapy-induced senescence drives bone loss

    Yao, Z., Murali, B., Ren, Q., Luo, X., Faget, D. V., Cole, T., Ricci, B., Thotala, D., Monahan, J., Van Deursen, J. M., Baker, D., Faccio, R., Schwarz, J. K. & Stewart, S. A., Mar 1 2020, In : Cancer research. 80, 5, p. 1171-1182 12 p.

    Research output: Contribution to journalArticle

  • 4 Scopus citations

    The tethering function of mitofusin2 controls osteoclast differentiation by modulating the Ca2+–NFATc1 axis

    Ballard, A., Zeng, R., Zarei, A., Shao, C., Cox, L., Yan, H., Franco, A., Dorn, G. W., Roberta Faccio, X. & Veis, X. D. J., May 8 2020, In : Journal of Biological Chemistry. 295, 19, p. 6629-6640 12 p.

    Research output: Contribution to journalArticle

    Open Access
  • 1 Scopus citations

    TREM2 Modulation Remodels the Tumor Myeloid Landscape Enhancing Anti-PD-1 Immunotherapy

    Molgora, M., Esaulova, E., Vermi, W., Hou, J., Chen, Y., Luo, J., Brioschi, S., Bugatti, M., Omodei, A. S., Ricci, B., Fronick, C., Panda, S. K., Takeuchi, Y., Gubin, M. M., Faccio, R., Cella, M., Gilfillan, S., Unanue, E. R., Artomov, M., Schreiber, R. D. & 1 others, Colonna, M., Aug 20 2020, In : Cell. 182, 4, p. 886-900.e17

    Research output: Contribution to journalArticle

  • 1 Scopus citations