Robert Schmidt

2023

Schwann Cell Remyelination in the Multiple Sclerosis Central Nervous System

Ghezzi, L., Bollman, B., De Feo, L., Piccio, L., Trapp, B. D., Schmidt, R. E. & Cross, A. H., Jun 1 2023, In: Laboratory investigation; a journal of technical methods and pathology. 103, 6, p. 100128 1 p.

Research output: Contribution to journal › Article › peer-review

Schwann cells and myelin in human peripheral nerve: Major protein components vary with age, axon size and pathology

Pestronk, A., Schmidt, R. E., Bucelli, R. & Sim, J., Apr 2023, In: Neuropathology and Applied Neurobiology. 49, 2, e12898.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Sleep deprivation exacerbates microglial reactivity and Aβ deposition in a TREM2-dependent manner in mice

Parhizkar, S., Gent, G., Chen, Y., Rensing, N., Gratuze, M., Strout, G., Sviben, S., Tycksen, E., Zhang, Q., Gilmore, P. E., Sprung, R., Malone, J., Chen, W., Serrano, J. R., Bao, X., Lee, C., Wang, C., Landsness, E., Fitzpatrick, J., Wong, M., & 4 othersTownsend, R., Colonna, M., Schmidt, R. E. & Holtzman, D. M., 2023, In: Science translational medicine. 15, 693, eade6285.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

2022

Evaluating brain damage in multiple sclerosis with simultaneous multi-angular-relaxometry of tissue

Xiang, B., Wen, J., Schmidt, R. E., Sukstanskii, A. L., Mamah, D., Yablonskiy, D. A. & Cross, A. H., Oct 2022, In: Annals of Clinical and Translational Neurology. 9, 10, p. 1514-1527 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Loss of Stathmin-2, a hallmark of TDP-43-associated ALS, causes motor neuropathy

Krus, K. L., Strickland, A., Yamada, Y., Devault, L., Schmidt, R. E., Bloom, A. J., Milbrandt, J. & DiAntonio, A., Jun 28 2022, In: Cell Reports. 39, 13, 111001.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Scopus citations

Macrophage depletion blocks congenital SARM1-dependent neuropathy

Dingwall, C. B., Strickland, A., Yum, S. W., Yim, A. K. Y., Zhu, J., Wang, P. L., Yamada, Y., Schmidt, R. E., Sasaki, Y., Joseph Bloom, A., DiAntonio, A. & Milbrandt, J., Dec 1 2022, In: Journal of Clinical Investigation. 132, 23, e159800.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Severe acute neurotoxicity reflects absolute intra-carotid 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine dose in non-human primates

Norris, S. A., White, H. C. B., Tanenbaum, A., Williams, E. L., Cruchaga, C., Tian, L., Schmidt, R. E. & Perlmutter, J. S., Jan 15 2022, In: Journal of Neuroscience Methods. 366, 109406.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Xanthogranulomatous epithelial tumors and keratin-positive giant cell-rich soft tissue tumors: two aspects of a single entity with frequent HMGA2-NCOR2 fusions

Dehner, C. A., Baker, J. C., Bell, R., Dickson, B. C., Schmidt, R. E., Demicco, E. G. & Chrisinger, J. S. A., Nov 2022, In: Modern Pathology. 35, 11, p. 1656-1666 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

2021

Overexpressing low-density lipoprotein receptor reduces tau-associated neurodegeneration in relation to apoE-linked mechanisms

Shi, Y., Andhey, P. S., Ising, C., Wang, K., Snipes, L. L., Boyer, K., Lawson, S., Yamada, K., Qin, W., Manis, M., Serrano, J. R., Benitez, B. A., Schmidt, R. E., Artyomov, M., Ulrich, J. D. & Holtzman, D. M., Aug 4 2021, In: Neuron. 109, 15, p. 2413-2426.e7

Research output: Contribution to journal › Article › peer-review

Open Access

46 Scopus citations

2020

In vivo evolution of biopsy-proven inflammatory demyelination quantified by R2t* mapping

Xiang, B., Wen, J., Lu, H. C., Schmidt, R. E., Yablonskiy, D. A. & Cross, A. H., Jun 1 2020, In: Annals of Clinical and Translational Neurology. 7, 6, p. 1055-1060 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Loss- or Gain-of-Function Mutations in ACOX1 Cause Axonal Loss via Different Mechanisms

Members of Undiagnosed Diseases Network, May 20 2020, In: Neuron. 106, 4, p. 589-606.e6

Research output: Contribution to journal › Article › peer-review

Open Access

56 Scopus citations

Peripheral nerve injury and sensitization underlie pain associated with oral cancer perineural invasion

Salvo, E., Campana, W. M., Scheff, N. N., Nguyen, T. H., Jeong, S. H., Wall, I., Wu, A. K., Zhang, S., Kim, H., Bhattacharya, A., Janal, M. N., Liu, C., Albertson, D. G., Schmidt, B. L., Dolan, J. C., Schmidt, R. E., Boada, M. D. & Ye, Y., Nov 1 2020, In: Pain. 161, 11, p. 2592-2602 11 p.

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Therapeutic enhancement of blood-brain and blood-Tumor barriers permeability by laser interstitial thermal therapy

Salehi, A., Paturu, M. R., Patel, B., Cain, M. D., Mahlokozera, T., Yang, A. B., Lin, T. H., Leuthardt, E. C., Yano, H., Song, S. K., Klein, R. S., Schmidt, R. & Kim, A. H., Jan 1 2020, In: Neuro-Oncology Advances. 2, 1, vdaa071.

Research output: Contribution to journal › Article › peer-review

Open Access

34 Scopus citations

Treatment of Progressive Multifocal Leukoencephalopathy Using Immune Restoration

Dunham, S. R., Schmidt, R. & Clifford, D. B., Jul 1 2020, In: Neurotherapeutics. 17, 3, p. 955-965 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

2019

Acute Posterior Multifocal Placoid Pigment Epitheliopathy Complicated by Fatal Cerebral Vasculitis

Maamari, R. N., Stunkel, L., Kung, N. H., Ferguson, C. J., Tanabe, J., Schmidt, R. E., Dahiya, S., Dhand, A., Van Stavern, G. P., Rajagopal, R. & Harocopos, G. J., Jun 1 2019, In: Journal of Neuro-Ophthalmology. 39, 2, p. 260-267 8 p.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

A mutation in Site-1 Protease is associated with a complex phenotype that includes episodic hyperCKemia and focal myoedema

Schweitzer, G. G., Gan, C., Bucelli, R. C., Wegner, D., Schmidt, R. E., Shinawi, M., Finck, B. N. & Brookheart, R. T., Jul 2019, In: Molecular Genetics and Genomic Medicine. 7, 7, e00733.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

Complex patterns of GABAergic neuronal deficiency and type 2 potassium-chloride cotransporter immaturity in human focal cortical dysplasia

Han, P., Welsh, C. T., Smith, M. T., Schmidt, R. E. & Carroll, S. L., Apr 1 2019, In: Journal of neuropathology and experimental neurology. 78, 4, p. 365-372 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

Diffusion basis spectrum imaging for identifying pathologies in MS subtypes

Shirani, A., Sun, P., Trinkaus, K., Perantie, D. C., George, A., Naismith, R. T., Schmidt, R. E., Song, S. K. & Cross, A. H., Nov 1 2019, In: Annals of Clinical and Translational Neurology. 6, 11, p. 2323-2327 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

Histopathological correlation of diffusion basis spectrum imaging metrics of a biopsy-proven inflammatory demyelinating brain lesion: A brief report

Shirani, A., Sun, P., Schmidt, R. E., Trinkaus, K., Naismith, R. T., Song, S. K. & Cross, A. H., Dec 1 2019, In: Multiple Sclerosis Journal. 25, 14, p. 1937-1941 5 p.

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Immune myopathy with large histiocyte-related myofiber necrosis

Pestronk, A., Sinha, N., Alhumayyd, Z., Ly, C., Schmidt, R. & Bucelli, R., Apr 9 2019, In: Neurology. 92, 15, p. e1763-e1772

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Mitochondriopathy: The unifying concept in distal neuropathies?

Schmidt, R. E., 2019, International Review of Neurobiology. Fernyhough, P. & Calcutt, N. A. (eds.). Academic Press Inc., p. 1-12 12 p. (International Review of Neurobiology; vol. 145).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

3 Scopus citations

Pituitary adenoma in pediatric and adolescent populations

Chen, J., Schmidt, R. E. & Dahiya, S., Jul 1 2019, In: Journal of neuropathology and experimental neurology. 78, 7, p. 626-632 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Scopus citations

Progressive multifocal leukoencephalopathy treated with nivolumab

Hoang, E., Bartlett, N. L., Goyal, M. S., Schmidt, R. E. & Clifford, D. B., Jan 1 2019, In: Journal of NeuroVirology.

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

2018

24 - White Matter and Myelin Disorders

Schmidt, R. E., Jan 1 2018, Practical Surgical Neuropathology: A Diagnostic Approach A Volume in the Pattern Recognition Series. Elsevier Inc., p. 581-616 36 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

A 60-Year-Old Woman with Multifocal Subcortical Infarcts

Schwetye, K. E., Rodriguez, D., Schmidt, R. E. & Dahiya, S., Jan 2018, In: Brain Pathology. 28, 1, p. 131-132 2 p.

Research output: Contribution to journal › Article › peer-review

Amyloid-β Plaques in clinical Alzheimer's disease brain incorporate stable isotope tracer in vivo and exhibit nanoscale heterogeneity

Wildburger, N. C., Gyngard, F., Guillermier, C., Patterson, B. W., Elbert, D., Mawuenyega, K. G., Schneider, T., Green, K., Roth, R., Schmidt, R. E., Cairns, N. J., Benzinger, T. L. S., Steinhauser, M. L. & Bateman, R. J., Mar 22 2018, In: Frontiers in Neurology. 9, MAR, 169.

Research output: Contribution to journal › Article › peer-review

Open Access

22 Scopus citations

An 8-Year-Old Girl with A Supratentorial Mass

Schwetye, K. E., Gauvain, K., Rodriguez, D., Cottrell, C., Limbrick, D. D., Schmidt, R. E. & Dahiya, S., Jan 2018, In: Brain Pathology. 28, 1, p. 125-126 2 p.

Research output: Contribution to journal › Comment/debate

Analysis of point mutations and copy number variation in Grade II and III meningioma

McNulty, S. N., Schwetye, K., Goldstein, M., Carter, J., Schmidt, R. E., Ansstas, G., Tsien, C. I., Kim, A. H. & Dahiya, S., Dec 2018, In: Experimental and Molecular Pathology. 105, 3, p. 328-333 6 p.

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Astrocytic degeneration in chronic traumatic encephalopathy

Hsu, E. T., Gangolli, M., Su, S., Holleran, L., Stein, T. D., Alvarez, V. E., McKee, A. C., Schmidt, R. E. & Brody, D. L., Dec 1 2018, In: Acta Neuropathologica. 136, 6, p. 955-972 18 p.

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Autoimmune Encephalitis with Multiple Autoantibodies: A Diagnostic and Therapeutic Challenge

Kim, A. E., Kang, P., Bucelli, R. C., Ferguson, C. J., Schmidt, R. E., Varadhachary, A. S. & Day, G. S., 2018, In: Neurologist. 23, 2, p. 55-59 5 p.

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Non-meningothelial meningeal tumours with meningioangiomatosis-like pattern of spread

Iorgulescu, J. B., Ferris, S., Agarwal, A., Casavilca Zambrano, S., Hill, D. A., Schmidt, R. & Perry, A., Dec 2018, In: Neuropathology and Applied Neurobiology. 44, 7, p. 743-746 4 p.

Research output: Contribution to journal › Letter › peer-review

5 Scopus citations

TREX1 is expressed by microglia in normal human brain and increases in regions affected by ischemia

Kothari, P. H., Kolar, G. R., Jen, J. C., Hajj-Ali, R., Bertram, P., Schmidt, R. E. & Atkinson, J. P., Nov 2018, In: Brain Pathology. 28, 6, p. 806-821 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

2017

A 12-Year-Old Girl With Encephalopathy and Acute Flaccid Paralysis: A Neuropathological Correlation and Cohort Review

Kim, Y. M., Orvedahl, A., Morris, S., Schmidt, R. & Mar, S., Jan 1 2017, In: Pediatric Neurology. 66, p. 5-11 7 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

A 42-Year-Old Man with AIDS and Multiple Incomplete Ring Enhancing Lesions

Kang, P., Schmidt, R. E., Dahiya, S. & Varadhachary, A. S., Sep 2017, In: Brain Pathology. 27, 5, p. 697-698 2 p.

Research output: Contribution to journal › Article › peer-review

Can anti-vascular endothelial growth factor antibody reverse radiation necrosis? A preclinical investigation

Duan, C., Perez-Torres, C. J., Yuan, L., Engelbach, J. A., Beeman, S. C., Tsien, C. I., Rich, K. M., Schmidt, R. E., Ackerman, J. J. H. & Garbow, J. R., May 1 2017, In: Journal of Neuro-Oncology. 133, 1, p. 9-16 8 p.

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Diffusion MRI quantifies early axonal loss in the presence of nerve swelling

Lin, T. H., Chiang, C. W., Perez-Torres, C. J., Sun, P., Wallendorf, M., Schmidt, R. E., Cross, A. H. & Song, S. K., Apr 7 2017, In: Journal of Neuroinflammation. 14, 1, 78.

Research output: Contribution to journal › Article › peer-review

Open Access

29 Scopus citations

JC virus granule cell neuronopathy in the setting of chronic lymphopenia treated with recombinant interleukin-7

Soleimani-Meigooni, D. N., Schwetye, K. E., Angeles, M. R., Ryschkewitsch, C. F., Major, E. O., Dang, X., Koralnik, I. J., Schmidt, R. E., Clifford, D. B., Kuhlmann, F. M. & Bucelli, R. C., Feb 1 2017, In: Journal of NeuroVirology. 23, 1, p. 141-146 6 p.

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Survival among children with “Lethal” congenital contracture syndrome 11 caused by novel mutations in the gliomedin gene (GLDN)

Wambach, J. A., Stettner, G. M., Haack, T. B., Writzl, K., Škofljanec, A., Maver, A., Munell, F., Ossowski, S., Bosio, M., Wegner, D. J., Shinawi, M., Baldridge, D., Alhaddad, B., Strom, T. M., Grange, D. K., Wilichowski, E., Troxell, R., Collins, J., Warner, B. B., Schmidt, R. E., & 3 othersPestronk, A., Cole, F. S. & Steinfeld, R., Nov 2017, In: Human mutation. 38, 11, p. 1477-1484 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Scopus citations

Synergistic effects of treating the spinal cord and brain in CLN1 disease

Shyng, C., Nelvagal, H. R., Dearborn, J. T., Tyynelä, J., Schmidt, R. E., Sands, M. S. & Cooper, J. D., Jul 18 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 29, p. E5920-E5929

Research output: Contribution to journal › Article › peer-review

Open Access

40 Scopus citations

The role of post-mortem MRI in the neonatal intensive care unit

Leadbetter, K. Z., Vesoulis, Z. A., White, F. V., Schmidt, R. E., Khanna, G., Shimony, J. S. & Mathur, A. M., Jan 1 2017, In: Journal of Perinatology. 37, 1, p. 98-103 6 p.

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Unusual high-grade features in pediatric diffuse leptomeningeal glioneuronal tumor: comparison with a typical low-grade example

Schwetye, K. E., Kansagra, A. P., McEachern, J., Schmidt, R. E., Gauvain, K. & Dahiya, S., Dec 2017, In: Human Pathology. 70, p. 105-112 8 p.

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Ventricular zone disruption in human neonates with intraventricular hemorrhage

McAllister, J. P., Guerra, M. M., Ruiz, L. C., Jimenez, A. J., Dominguez-Pinos, D., Sival, D., den Dunnen, W., Morales, D. M., Schmidt, R. E., Rodriguez, E. M. & Limbrick, D. D., May 1 2017, In: Journal of neuropathology and experimental neurology. 76, 5, p. 358-375 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

67 Scopus citations

2016

A complement-microglial axis drives synapse loss during virus-induced memory impairment

Vasek, M. J., Garber, C., Dorsey, D., Durrant, D. M., Bollman, B., Soung, A., Yu, J., Perez-Torres, C., Frouin, A., Wilton, D. K., Funk, K., DeMasters, B. K., Jiang, X., Bowen, J. R., Mennerick, S., Robinson, J. K., Garbow, J. R., Tyler, K. L., Suthar, M. S., Schmidt, R. E., & 2 othersStevens, B. & Klein, R. S., Jun 22 2016, In: Nature. 534, 7608, p. 538-543 6 p.

Research output: Contribution to journal › Article › peer-review

415 Scopus citations

Clec16a is Critical for Autolysosome Function and Purkinje Cell Survival

Redmann, V., Lamb, C. A., Hwang, S., Orchard, R. C., Kim, S., Razi, M., Milam, A., Park, S., Yokoyama, C. C., Kambal, A., Kreamalmeyer, D., Bosch, M. K., Xiao, M., Green, K., Kim, J., Pruett-Miller, S. M., Ornitz, D. M., Allen, P. M., Beatty, W. L., Schmidt, R. E., & 3 othersDiantonio, A., Tooze, S. A. & Virgin, H. W., Mar 18 2016, In: Scientific reports. 6, 23326.

Research output: Contribution to journal › Article › peer-review

Open Access

25 Scopus citations

Gliosarcomas lack BRAF^V600E mutation, but a subset exhibit β-catenin nuclear localization

Schwetye, K. E., Joseph, N. M., Al-Kateb, H., Rich, K. M., Schmidt, R. E., Perry, A., Gutmann, D. H. & Dahiya, S., Oct 1 2016, In: Neuropathology. 36, 5, p. 448-455 8 p.

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Group II mGluRs suppress hyperexcitability in mouse and human nociceptors

Davidson, S., Golden, J. P., Copits, B. A., Ray, P. R., Vogt, S. K., Valtcheva, M. V., Schmidt, R. E., Ghetti, A., Price, T. J. & Gereau, R. W., Sep 1 2016, In: Pain. 157, 9, p. 2081-2088 8 p.

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Immunogenomics of hypermutated glioblastoma: A patient with germline POLE deficiency treated with checkpoint blockade immunotherapy

Johanns, T. M., Miller, C. A., Dorward, I. G., Tsien, C., Chang, E., Perry, A., Uppaluri, R., Ferguson, C., Schmidt, R. E., Dahiya, S., Ansstas, G., Mardis, E. R. & Dunn, G. P., Nov 2016, In: Cancer discovery. 6, 11, p. 1230-1236 7 p.

Research output: Contribution to journal › Article › peer-review

223 Scopus citations

Molecular and histologic characteristics of pseudoprogression in diffuse gliomas

Lin, A. L., White, M., Miller-Thomas, M. M., Fulton, R. S., Tsien, C., Rich, K. M., Schmidt, R. E., Tran, D. D. & Dahiya, S., Dec 1 2016, In: Journal of Neuro-Oncology. 130, 3, p. 529-533 5 p.

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations

Stam, A. H., Kothari, P. H., Shaikh, A., Gschwendter, A., Jen, J. C., Hodgkinson, S., Hardy, T. A., Hayes, M., Kempster, P. A., Kotschet, K. E., Bajema, I. M., Van Duinen, S. G., Maat-Schieman, M. L. C., De Jong, P. T. V. M., De Smet, M. D., De Wolff-Rouendaal, D., Dijkman, G., Pelzer, N., Kolar, G. R., Schmidt, R. E., & 17 othersLacey, J. A., Joseph, D., Fintak, D. R., Grand, M. G., Brunt, E. M., Liapis, H., Hajj-Ali, R. A., Kruit, M. C., Van Buchem, M. A., Dichgans, M., Frants, R. R., Van Den Maagdenberg, A. M. J. M., Haan, J., Baloh, R. W., Atkinson, J. P., Terwindt, G. M. & Ferrari, M. D., Nov 1 2016, In: Brain. 139, 11, p. 2909-2922 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

96 Scopus citations

2015

A gamma-knife-enabled mouse model of cerebral single-hemisphere delayed radiation necrosis

Jiang, X., Yuan, L., Engelbach, J. A., Cates, J., Perez-Torres, C. J., Gao, F., Thotala, D., Drzymala, R. E., Schmidt, R. E., Rich, K., Hallahan, D. E., Ackerman, J. J. H. & Garbow, J. R., Oct 6 2015, In: PloS one. 10, 10, e0139596.

Research output: Contribution to journal › Article › peer-review

Open Access

29 Scopus citations

Robert Schmidt

Research output

Search results