Robert Schmidt

Professor of Pathology and Immunology

    • 11436 Citations
    1975 …2020

    Research output per year

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    Personal profile

    Research interests

    Interference with the normal function of peripheral nerve underlies a variety of neurologic diseases and provides a window for elucidation of basic mechanisms of axonal function. Our research involves the determination of the mechanisms underlying the response of the PNS to various forms of toxic, infectious, immunologic, age-related and metabolic injury. We have developed and characterized several animal models of diabetic autonomic neuropathy involving rats and mice with streptozotocin-induced diabetes and genetically diabetic NOD mice using biochemical, immunohistochemical, physiologic and ultrastructural techniques. We examine the potential of insulin therapy and treatment with newer therapeutic agents and neurotrophic substances (IGF-I, NGF, NT-3) to prevent neuropathy and reverse established neuropathic lesions. Our working hypothesis is that oxidative stress causes nerve terminal injury and is the initiating stimulus in the development of neuroaxonal dystrophy and that there is an age- and diabetes-related defect in synaptic plasticity which is secondary to an abnormal neurotrophic milieu.

    Areas of Clinical Interest

    Peripheral neuropathy, white matter diseases including multiple sclerosis, brain tumors, general neuropathology

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    Research Output

    In vivo evolution of biopsy-proven inflammatory demyelination quantified by R2t* mapping

    Xiang, B., Wen, J., Lu, H. C., Schmidt, R. E., Yablonskiy, D. A. & Cross, A. H., Jun 1 2020, In : Annals of Clinical and Translational Neurology. 7, 6, p. 1055-1060 6 p.

    Research output: Contribution to journalArticle

    Open Access
  • Loss- or Gain-of-Function Mutations in ACOX1 Cause Axonal Loss via Different Mechanisms

    Members of Undiagnosed Diseases Network, May 20 2020, In : Neuron. 106, 4, p. 589-606.e6

    Research output: Contribution to journalArticle

  • 3 Scopus citations

    Treatment of Progressive Multifocal Leukoencephalopathy Using Immune Restoration

    Dunham, S. R., Schmidt, R. & Clifford, D. B., Jan 1 2020, (Accepted/In press) In : Neurotherapeutics.

    Research output: Contribution to journalArticle

  • 2 Scopus citations
  • 1 Scopus citations
    Open Access
  • 3 Scopus citations