• 3167 Citations
1981 …2014

Research output per year

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Personal profile

Research interests

Mutations in the KCNJ10 gene are responsible for a diverse range of abnormalities that includes epilepsy, deafness, ataxia, mental retardation and electrolyte imbalance.  This syndrome, termed SeSAME (seizures, sensorineural deafness, ataxia, mental retardation and electrolyte abnormalities) is a result of the loss in function of the Kir4.1 potassium channel. While some of the mutations compromise channel activity, several of the mutations decrease plasma membrane channel expression.  However, it remains to be determined if any of the identified SeSAME mutations affect the polarized sorting of the Kir4.1 polypeptide to the basolateral surface of epithelial cells.  To better characterize the trafficking of Kir4.1 to the basolateral membrane we are expressing wild-type and mutant Kir4.1 polypeptides in polarized cells. In addition we are determining if expression of wild-type or mutant Kir4.1 polypeptides in cells influences the Na,K-ATPase activity to modify transepithelial potential, resistance, transport or short-circuit currents. These studies will provide important understandings into the physiological consequences of loss of Kir4.1 function and will help explain the abnormalities associated with the disease.

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Research Output

  • 3167 Citations
  • 54 Article
  • 1 Review article

Intracellular calcium regulates nonsense-mediated mRNA decay

Nickless, A., Jackson, E., Marasa, J., Nugent, P., Mercer, R. W., Piwnica-Worms, D. & You, Z., Aug 2014, In : Nature medicine. 20, 8, p. 961-966 6 p.

Research output: Contribution to journalArticle

  • 40 Scopus citations

    Regulation of mouse embryonic stem cell neural differentiation by retinoic acid

    Kim, M., Habiba, A., Doherty, J. M., Mills, J. C., Mercer, R. W. & Huettner, J. E., Apr 15 2009, In : Developmental Biology. 328, 2, p. 456-471 16 p.

    Research output: Contribution to journalArticle

    Open Access
  • 75 Scopus citations

    Human FXYD2 G41R mutation responsible for renal hypomagnesemia behaves as an inward-rectifying cation channel

    Sha, Q., Pearson, W., Burcea, L. C., Wigfall, D. A., Schlesinger, P. H., Nichols, C. G. & Mercer, R. W., Jul 2008, In : American Journal of Physiology - Renal Physiology. 295, 1, p. F91-F99

    Research output: Contribution to journalArticle

  • 19 Scopus citations

    Cytoplasmic targeting signals mediate delivery of phospholemman to the plasma membrane

    Lansbery, K. L., Burcea, L. C., Mendenhall, M. L. & Mercer, R. W., May 2006, In : American Journal of Physiology - Cell Physiology. 290, 5, p. C1275-C1286

    Research output: Contribution to journalArticle

  • 22 Scopus citations

    Akt-dependent cell size regulation by the adhesion molecule on glia occurs independently of phosphatidylinositol 3-kinase and Rheb signaling

    Scheidenhelm, D. K., Cresswell, J., Haipek, C. A., Fleming, T. P., Mercer, R. W. & Gutmann, D. H., Apr 2005, In : Molecular and cellular biology. 25, 8, p. 3151-3162 12 p.

    Research output: Contribution to journalArticle

    Open Access
  • 21 Scopus citations