Robert Gropler

Professor of Radiology, Associate Professor of Medicine, Associate Professor of Biomedical Engineering

    • 5943 Citations
    1990 …2020

    Research output per year

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    Personal profile

    Research interests

    The focus of our investigative efforts is on the role of myocardial metabolic remodeling in both normal and abnormal cardiac states. Quantification of myocardial perfusion and substrate metabolism is performed with positron emission tomography using novel PET radiopharmaceuticals and well-validated kinetic models. The measurements of myocardial perfusion and metabolism are then correlated to measurements of left ventricular systolic and diastolic function obtained with either echocardiography or MRI. These measurements are obtained in variety models of disease ranging from rodents to humans. Active areas of investigation include the role nitric oxide and peroxisome proliferator-activated receptor on the age related decline in myocardial fatty acid metabolism, the effect of fatty acid delivery on myocardial substrate metabolism in type 2 diabetes mellitus, and the relationship between myocardial and whole-body substrate metabolism in obesity.

    Areas of Clinical Interest

    Nuclear medicine, cardiovascular imaging, coronary artery disease, PET imaging

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    Research Output

    64Cu-ATSM positron emission tomography/ magnetic resonance imaging of hypoxia in human atherosclerosis

    Nie, X., Elvington, A., Laforest, R., Zheng, J., Voller, T. F., Zayed, M. A., Abendschein, D. R., Bandara, N., Xu, J., Li, R., Randolph, G. J., Gropler, R. J., Lapi, S. E. & Woodard, P. K., Jan 1 2020, In : Circulation: Cardiovascular Imaging. e009791.

    Research output: Contribution to journalLetter

    1 Scopus citations

    Acute Rodent Tolerability, Toxicity, and Radiation Dosimetry Estimates of the S1P1-Specific Radioligand [11C]CS1P1

    Liu, H., Laforest, R., Gu, J., Luo, Z., Jones, L. A., Gropler, R. J., Benzinger, T. L. S. & Tu, Z., Apr 1 2020, In : Molecular Imaging and Biology. 22, 2, p. 285-292 8 p.

    Research output: Contribution to journalArticle

  • Appropriate Use Criteria for PET Myocardial Perfusion Imaging

    Schindler, T. H., Bateman, T. M., Berman, D. S., Chareonthaitawee, P., De Blanche, L. E., Dilsizian, V., Dorbala, S., Gropler, R. J., Shaw, L., Soman, P., Winchester, D. E., Verberne, H., Ahuja, S., Beanlands, R. S., Di Carli, M. F., Murthy, V. L., Ruddy, T. D. & Schwartz, R. G., Aug 1 2020, In : Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 61, 8, p. 1221-1265 45 p.

    Research output: Contribution to journalArticle

    1 Scopus citations

    CCR2 positron emission tomography for the assessment of abdominal aortic aneurysm inflammation and rupture prediction

    English, S. J., Sastriques, S. E., Detering, L., Sultan, D., Luehmann, H., Arif, B., Heo, G. S., Zhang, X., Laforest, R., Zheng, J., Lin, C. Y., Gropler, R. J. & Liu, Y., Mar 1 2020, In : Circulation: Cardiovascular Imaging. e009889.

    Research output: Contribution to journalArticle

  • 1 Scopus citations