Personal profile
Research interests
The focus of our laboratory is on developing effective therapies for sepsis. Specifically, we are concentrating on prevention of the widespread apoptosis of immune effector cells that is a hallmark of the disorder. A variety of anti-apoptotic strategies are employed. In addition, we are endeavoring to inhibit the immunosuppressive phenotype that occurs during sepsis and which contributes to the immunoparalysis that is a major feature of this disorder.
Keywords
- COVID-19
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Collaborations and top research areas from the last five years
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IL-7: a potential next-generation adjuvant for immune cell therapies
Hotchkiss, R. S., DiPersio, J. F., Yee, C., Pachynski, R. K. & Van Den Brink, M. R. M., 2026, In: Frontiers in immunology. 16, 1736931.Research output: Contribution to journal › Article › peer-review
Open Access -
Prevention of secondary infections by interferon-gamma in ICU-acquired sustained immune suppression in France: study protocol of the PLATINIUM randomised trial
Hernandez Padilla, A. C., Daix, T., Hotchkiss, R. S., Monneret, G., Tadie, J. M., Jeannet, R., Plateker, O., Vaidie, J., Durand-Zaleski, I., Magne, J., Giraudeau, B. & François, B., Jan 27 2026, In: BMJ Open. 16, 1, e106790.Research output: Contribution to journal › Article › peer-review
Open Access -
Quantifying Nuance Within Sepsis-Associated Immune Suppression Toward Diagnostic Certainty
Caldwell, C. C., Maile, R., Mazer, M. B., McGonagill, P. W., Bergmann, C. B., Gould, R. W., Rao, M., Hernández-Ríos, M., Ungaro, R. F., Loftus, T. J., Efron, P. A., Remy, K. E., Brakenridge, S. C., Badovinac, V. P., Griffith, T. S., Hotchkiss, R. S. & Moldawer, L. L., Mar 2026, In: Shock. 65, 3, p. 555-559 5 p.Research output: Contribution to journal › Article › peer-review
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A randomized, double-blind, placebo-controlled trial of IL-7 in critically ill patients with COVID-19
Shankar-Hari, M., Francois, B., Remy, K. E., Gutierrez, C., Pastores, S., Daix, T., Jeannet, R., Blood, J., Walton, A. H., Salomao, R., Auzinger, G., Striker, D., Martin, R. S., Anand, N. J., Bosanquet, J., Blood, T., Brakenridge, S., Moldawer, L. L., Vachharajani, V. & Yee, C. & 5 others, , Mar 24 2025, In: JCI Insight. 10, 6, e189150.Research output: Contribution to journal › Article › peer-review
Open Access17 Link opens in a new tab Scopus citations -
Determining potential immunomodulatory drug efficacy in sepsis using ELISpot
Walton, A. H., Mazer, M. B., Remy, K. E., Osborne, D. F., Davitt, E. B., Griffith, T. S., Gould, R. W., Badovinac, V. P., Brakenridge, S. C., Drewry, A. M., Ungaro, R. F., Rocha, I. L., Loftus, T. J., Efron, P. A., Moldawer, L. L., Caldwell, C. C. & Hotchkiss, R. S., Dec 2025, In: Scientific reports. 15, 1, 13464.Research output: Contribution to journal › Article › peer-review
Open Access3 Link opens in a new tab Scopus citations