Research output per year
Research output per year
Personal profile
Research interests
The focus of our laboratory is on developing effective therapies for sepsis. Specifically, we are concentrating on prevention of the widespread apoptosis of immune effector cells that is a hallmark of the disorder. A variety of anti-apoptotic strategies are employed. In addition, we are endeavoring to inhibit the immunosuppressive phenotype that occurs during sepsis and which contributes to the immunoparalysis that is a major feature of this disorder.
Keywords
- COVID-19
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Collaborations and top research areas from the last five years
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FUNCTIONAL IMMUNOPHENOTYPING FOR PRECISION THERAPIES IN SEPSIS
Rao, M., Mcgonagill, P. W., Brackenridge, S., Remy, K. E., Caldwell, C. C., Hotchkiss, R. S., Moldawer, L. L., Griffith, T. S. & Badovinac, V. P., Feb 1 2025, In: Shock. 63, 2, p. 189-201 13 p.Research output: Contribution to journal › Article › peer-review
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Adverse outcomes and an immunosuppressed endotype in septic patients with reduced IFN-γ ELISpot
Barrios, E. L., Mazer, M. B., McGonagill, P. W., Bergmann, C. B., Goodman, M. D., Gould, R. W., Rao, M., Polcz, V. E., Davis, R. J., Del Toro, D. E., Dirain, M. L. S., Dram, A., Hale, L. O., Heidarian, M., Kim, C. Y., Kucaba, T. A., Lanz, J. P., McCray, A. E., Meszaros, S. & Miles, S. & 20 others, , Jan 2024, In: JCI Insight. 9, 2, e175785.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Development and optimization of a diluted whole blood ELISpot assay to test immune function
Ungaro, R. F., Xu, J., Kucaba, T. A., Rao, M., Bergmann, C. B., Brakenridge, S. C., Efron, P. A., Goodman, M. D., Gould, R. W., Hotchkiss, R. S., Liang, M., Mazer, M. B., McGonagill, P. W., Moldawer, L. L., Remy, K. E., Turnbull, I. R., Caldwell, C. C., Badovinac, V. P. & Griffith, T. S., Oct 2024, In: Journal of Immunological Methods. 533, 113743.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
EARLY PERSISTENT LYMPHOPENIA AND RISK OF DEATH IN CRITICALLY ILL PATIENTS WITH AND WITHOUT SEPSIS
Adigbli, D., Liu, R., Meyer, J., Cohen, J., Di Tanna, G. L., Gianacas, C., Bhattacharya, A., Hammond, N., Walsham, J., Venkatesh, B., Hotchkiss, R. & Finfer, S., Feb 1 2024, In: Shock. 61, 2, p. 197-203 7 p.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Reframing sepsis immunobiology for translation: towards informative subtyping and targeted immunomodulatory therapies
Shankar-Hari, M., Calandra, T., Soares, M. P., Bauer, M., Wiersinga, W. J., Prescott, H. C., Knight, J. C., Baillie, K. J., Bos, L. D. J., Derde, L. P. G., Finfer, S., Hotchkiss, R. S., Marshall, J., Openshaw, P. J. M., Seymour, C. W., Venet, F., Vincent, J. L., Le Tourneau, C., Maitland-van der Zee, A. H. & McInnes, I. B. & 1 others, , Apr 2024, In: The Lancet Respiratory Medicine. 12, 4, p. 323-336 14 p.Research output: Contribution to journal › Review article › peer-review
Open Access25 Scopus citations