Richard Hotchkiss

Professor of Anesthesiology, Professor of Surgery, Professor of Developmental Biology, Professor of Medicine

    • 27670 Citations
    1983 …2020

    Research output per year

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    Personal profile

    Research interests

    The focus of our laboratory is on developing effective therapies for sepsis. Specifically, we are concentrating on prevention of the widespread apoptosis of immune effector cells that is a hallmark of the disorder. A variety of anti-apoptotic strategies are employed. In addition, we are endeavoring to inhibit the immunosuppressive phenotype that occurs during sepsis and which contributes to the immunoparalysis that is a major feature of this disorder.

    Keywords

    • COVID-19

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    Research Output

    Activating immunity to fight a foe - A new path

    Hotchkiss, R. S. & Opal, S. M., Mar 26 2020, In : New England Journal of Medicine. 382, 13, p. 1270-1272 3 p.

    Research output: Contribution to journalArticle

    8 Scopus citations

    Association of Interleukin 7 Immunotherapy With Lymphocyte Counts Among Patients With Severe Coronavirus Disease 2019 (COVID-19)

    Laterre, P. F., François, B., Collienne, C., Hantson, P., Jeannet, R., Remy, K. E. & Hotchkiss, R. S., Jul 1 2020, In : JAMA Network Open. 3, 7, p. e2016485

    Research output: Contribution to journalArticle

    Open Access
    3 Scopus citations

    Circulating BiP/Grp78 is a novel prognostic marker for sepsis-mediated immune cell death

    Doerflinger, M., Reljic, B., Menassa, J., Nedeva, C., Jose, I., Faou, P., Mackiewicz, L., Mansell, A., Pellegrini, M., Hotchkiss, R. & Puthalakath, H., 2020, (Accepted/In press) In : FEBS Journal.

    Research output: Contribution to journalArticle

  • Immunotherapies for COVID-19: lessons learned from sepsis

    Remy, K. E., Brakenridge, S. C., Francois, B., Daix, T., Deutschman, C. S., Monneret, G., Jeannet, R., Laterre, P. F., Hotchkiss, R. S. & Moldawer, L. L., Oct 2020, In : The Lancet Respiratory Medicine. 8, 10, p. 946-949 4 p.

    Research output: Contribution to journalComment/debate

    Open Access
    12 Scopus citations

    Low-dose interleukin-2 reverses behavioral sensitization in multiple mouse models of headache disorders

    Zhang, J., Czerpaniak, K., Huang, L., Liu, X., Cloud, M. E., Unsinger, J., Hotchkiss, R. S., Li, D. & Cao, Y. Q., Jun 1 2020, In : Pain. 161, 6, p. 1381-1398 18 p.

    Research output: Contribution to journalArticle

    Open Access