Research output per year
Research output per year
Personal profile
Research interests
The focus of our laboratory is on developing effective therapies for sepsis. Specifically, we are concentrating on prevention of the widespread apoptosis of immune effector cells that is a hallmark of the disorder. A variety of anti-apoptotic strategies are employed. In addition, we are endeavoring to inhibit the immunosuppressive phenotype that occurs during sepsis and which contributes to the immunoparalysis that is a major feature of this disorder.
Keywords
- COVID-19
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COVID-19 disease and immune dysregulation
Davitt, E., Davitt, C., Mazer, M. B., Areti, S. S., Hotchkiss, R. S. & Remy, K. E., Sep 2022, In: Best Practice and Research: Clinical Haematology. 35, 3, 101401.Research output: Contribution to journal › Review article › peer-review
4 Scopus citations -
Dysregulation of the leukocyte signaling landscape during acute COVID-19
Turnbull, I. R., Fuchs, A., Remy, K. E., Kelly, M. P., Frazier, E. P., Ghosh, S., Chang, S. W., Mazer, M. B., Hess, A., Leonard, J. M., Hoofnagle, M. H., Colonna, M. & Hotchkiss, R. S., Apr 2022, In: PloS one. 17, 4 April, e0264979.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Functional Characterization of Neutrophils Allows Source Control Evaluation in a Murine Sepsis Model
Salyer, C. E., Bergmann, C. B., Hotchkiss, R. S., Crisologo, P. A. & Caldwell, C. C., Jun 2022, In: Journal of Surgical Research. 274, p. 94-101 8 p.Research output: Contribution to journal › Article › peer-review
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Inhibiting Mycobacterium abscessus Cell Wall Synthesis: Using a Novel Diazabicyclooctane b-Lactamase Inhibitor To Augment b-Lactam Action
Dousa, K. M., Nguyen, D. C., Kurz, S. G., Taracila, M. A., Bethel, C. R., Schinabeck, W., Kreiswirth, B. N., Brown, S. T., Henry Boom, W., Hotchkiss, R. S., Remy, K. E., Jacono, F. J., Daley, C. L., Holland, S. M., Miller, A. A. & Bonomo, R. A., Feb 1 2022, In: mBio. 13, 1, e03529.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
Low-dose interleukin-2 reverses chronic migraine-related sensitizations through peripheral interleukin-10 and transforming growth factor beta-1 signaling
Guo, Z., Zhang, J., Liu, X., Unsinger, J., Hotchkiss, R. S. & Cao, Y. Q., Aug 1 2022, In: Neurobiology of Pain. 12, 100096.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations