Richard Gross

Professor of Medicine, Professor of Developmental Biology, Professor of Chemistry

  • 17639 Citations
1977 …2019
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Personal profile

Research interests

Our research is focused on the chemical biology of membranes in health and disease. Biologic membranes are comprised of a structurally diverse array of thousands of distinct chemical entities in a bilayer configuration that are in constant motion providing a rich repertoire of chemical forces that can be used to modulate the conformation and function of transmembrane proteins such as ion channels and ion pumps. Through adaptation of a bilayer structure membranes serve as a hydrophobic scaffold for the organization of complex supramolecular chemical assemblies that are used in biologic systems as signaling platforms.

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Calcium-Independent Phospholipase A2 Medicine & Life Sciences
Phospholipases A2 Medicine & Life Sciences
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Arachidonic Acid Medicine & Life Sciences
Lipids Medicine & Life Sciences
Myocardium Medicine & Life Sciences
Phosphatidylcholines Medicine & Life Sciences
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Research Output 1977 2019

17 Citations (Scopus)

Ferroptotic cell death and TLR4/Trif signaling initiate neutrophil recruitment after heart transplantation

Li, W., Feng, G., Gauthier, J. M., Lokshina, I., Higashikubo, R., Evans, S., Liu, X., Hassan, A., Tanaka, S., Cicka, M., Hsiao, H. M., Ruiz-Perez, D., Bredemeyer, A., Gross, R. W., Mann, D. L., Tyurina, Y. Y., Gelman, A. E., Kagan, V. E., Linkermann, A., Lavine, K. J. & 1 others, Kreisel, D., Jun 3 2019, In : Journal of Clinical Investigation. 129, 6, p. 2293-2304 12 p.

Research output: Contribution to journalArticle

Open Access
Neutrophil Infiltration
Heart Transplantation
Cell Death
Reperfusion Injury
1 Citation (Scopus)

Synthesis of oxidized phospholipids by sn-1 acyltransferase using 2–15-HETE lysophospholipids

Liu, G. Y., Moon, S. H., Jenkins, C. M., Sims, H. F., Guan, S. & Gross, R. W., Jan 1 2019, In : Journal of Biological Chemistry. 294, 26, p. 10146-10159 14 p.

Research output: Contribution to journalArticle

Hydroxyeicosatetraenoic Acids
Acyl Coenzyme A
10 Citations (Scopus)

Caveolin-1 regulates lipid droplet metabolism in endothelial cells via autocrine prostacyclin–stimulated, cAMP-mediated lipolysis

Kuo, A., Lee, M. Y., Yang, K., Gross, R. W. & Sessa, W. C., Jan 1 2018, In : Journal of Biological Chemistry. 293, 3, p. 973-983 11 p.

Research output: Contribution to journalArticle

Caveolin 1
Endothelial cells
Lipid Metabolism
10 Citations (Scopus)

Cytochrome c is an oxidative stress–activated plasmalogenase that cleaves plasmenylcholine and plasmenylethanolamine at the sn-1 vinyl ether linkage

Jenkins, C. M., Yang, K., Liu, G., Moon, S. H., Dilthey, B. G. & Gross, R. W., Jan 1 2018, In : Journal of Biological Chemistry. 293, 22, p. 8693-8709 17 p.

Research output: Contribution to journalArticle

Open Access
Cytochromes c
Arachidonic Acid
8 Citations (Scopus)

Heart failure-induced activation of phospholipase iPLA2γ generates hydroxyeicosatetraenoic acids opening the mitochondrial permeability transition pore

Moon, S. H., Liu, X., Cedars, A. M., Yang, K., Kiebish, M. A., Joseph, S. M., Kelley, J., Jenkins, C. M. & Gross, R. W., Jan 1 2018, In : Journal of Biological Chemistry. 293, 1, p. 115-129 15 p.

Research output: Contribution to journalReview article

Open Access
Hydroxyeicosatetraenoic Acids
Phospholipases A2
Heart Failure
Chemical activation