Ramaswamy Govindan

2021

Sotorasib for lung cancers with KRAS P.G12C mutation

Skoulidis, F., Li, B. T., Dy, G. K., Price, T. J., Falchook, G. S., Wolf, J., Italiano, A., Schuler, M., Borghaei, H., Barlesi, F., Kato, T., Curioni-Fontecedro, A., Sacher, A., Spira, A., Ramalingam, S. S., Takahashi, T., Besse, B., Anderson, A., Ang, A. & Tran, Q. & 6 others, Mather, O., Henary, H., Ngarmchamnanrith, G., Friberg, G., Velcheti, V. & Govindan, R., Jun 24 2021, In: New England Journal of Medicine. 384, 25, p. 2371-2381 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

932 Scopus citations

Veliparib in Combination With Platinum- Based Chemotherapy for First-Line Treatment of Advanced Squamous Cell Lung Cancer: A Randomized, Multicenter Phase III Study

Ramalingam, S. S., Novello, S., Guclu, S. Z., Bentsion, D., Zvirbule, Z., Szilasi, M., Bernabe, R., Syrigos, K., Byers, L. A., Clingan, P., Bar, J., Vokes, E. E., Govindan, R., Dunbar, M., Ansell, P., He, L., Huang, X., Sehgal, V., Glasgow, J. & Bach, B. A. & 1 others, Mazieres, J., Nov 10 2021, In: Journal of Clinical Oncology. 39, 32, p. 3633-3644 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

35 Scopus citations

Whole-genome characterization of lung adenocarcinomas lacking the RTK/RAS/RAF pathway

TCGA Research Network, Feb 2 2021, In: Cell Reports. 34, 5, 108707.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

2020

A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns

PCAWG Tumor Subtypes and Clinical Translation Working Group & PCAWG Consortium, Dec 1 2020, In: Nature communications. 11, 1, 728.

Research output: Contribution to journal › Article › peer-review

Open Access

127 Scopus citations

Analyses of non-coding somatic drivers in 2,658 cancer whole genomes

PCAWG Consortium, PCAWG Drivers and Functional Interpretation Working Group & PCAWG-Structural Variation Working Group, Feb 6 2020, In: Nature. 578, 7793, p. 102-111 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

361 Scopus citations

A Phase Ib Trial of Personalized Neoantigen Therapy Plus Anti-PD-1 in Patients with Advanced Melanoma, Non-small Cell Lung Cancer, or Bladder Cancer

Ott, P. A., Hu-Lieskovan, S., Chmielowski, B., Govindan, R., Naing, A., Bhardwaj, N., Margolin, K., Awad, M. M., Hellmann, M. D., Lin, J. J., Friedlander, T., Bushway, M. E., Balogh, K. N., Sciuto, T. E., Kohler, V., Turnbull, S. J., Besada, R., Curran, R. R., Trapp, B. & Scherer, J. & 19 others, Poran, A., Harjanto, D., Barthelme, D., Ting, Y. S., Dong, J. Z., Ware, Y., Huang, Y., Huang, Z., Wanamaker, A., Cleary, L. D., Moles, M. A., Manson, K., Greshock, J., Khondker, Z. S., Fritsch, E., Rooney, M. S., DeMario, M., Gaynor, R. B. & Srinivasan, L., Oct 15 2020, In: Cell. 183, 2, p. 347-362.e24

Research output: Contribution to journal › Article › peer-review

Open Access

377 Scopus citations

Cancer LncRNA Census reveals evidence for deep functional conservation of long noncoding RNAs in tumorigenesis

PCAWG Drivers and Functional Interpretation Group & PCAWG Consortium, Dec 1 2020, In: Communications Biology. 3, 1, 56.

Research output: Contribution to journal › Article › peer-review

Open Access

145 Scopus citations

Combined burden and functional impact tests for cancer driver discovery using DriverPower

PCAWG Drivers and Functional Interpretation Working Group & PCAWG Consortium, Dec 1 2020, In: Nature communications. 11, 1, 734.

Research output: Contribution to journal › Article › peer-review

Open Access

25 Scopus citations

Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing

PCAWG-Structural Variation Working Group & PCAWG Consortium, Mar 1 2020, In: Nature Genetics. 52, 3, p. 331-341 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

392 Scopus citations

Comprehensive molecular characterization of mitochondrial genomes in human cancers

PCAWG Consortium, Mar 1 2020, In: Nature Genetics. 52, 3, p. 342-352 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

234 Scopus citations

Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer

PCAWG-Structural Variation Working Group & PCAWG Consortium, Mar 1 2020, In: Nature Genetics. 52, 3, p. 294-305 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

154 Scopus citations

Divergent mutational processes distinguish hypoxic and normoxic tumours

PCAWG Consortium, Dec 1 2020, In: Nature communications. 11, 1, 737.

Research output: Contribution to journal › Article › peer-review

Open Access

84 Scopus citations

Genomic basis for RNA alterations in cancer

PCAWG Transcriptome Core Group, PCAWG Transcriptome Working Group & PCAWG Consortium, Feb 6 2020, In: Nature. 578, 7793, p. 129-136 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

261 Scopus citations

Genomic footprints of activated telomere maintenance mechanisms in cancer

PCAWG-Structural Variation Working Group & PCAWG Consortium, Dec 1 2020, In: Nature communications. 11, 1, 733.

Research output: Contribution to journal › Article › peer-review

Open Access

75 Scopus citations

High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations

PCAWG Transcriptome Working Group, PCAWG-Structural Variation Working Group & PCAWG Consortium, Dec 1 2020, In: Nature communications. 11, 1, 736.

Research output: Contribution to journal › Article › peer-review

Open Access

49 Scopus citations

Inferring structural variant cancer cell fraction

PCAWG Evolution and Heterogeneity Working Group & PCAWG Consortium, Dec 1 2020, In: Nature communications. 11, 1, 730.

Research output: Contribution to journal › Article › peer-review

Open Access

29 Scopus citations

Integrative pathway enrichment analysis of multivariate omics data

PCAWG Drivers and Functional Interpretation Working Group & PCAWG Consortium, Dec 1 2020, In: Nature communications. 11, 1, 735.

Research output: Contribution to journal › Article › peer-review

Open Access

112 Scopus citations

KrAs^G12C inhibition with sotorasib in advanced solid tumors

Hong, D. S., Fakih, M. G., Strickler, J. H., Desai, J., Durm, G. A., Shapiro, G. I., Falchook, G. S., Price, T. J., Sacher, A., Denlinger, C. S., Bang, Y. J., Dy, G. K., Krauss, J. C., Kuboki, Y., Kuo, J. C., Coveler, A. L., Park, K., Kim, T. W., Barlesi, F. & Munster, P. N. & 14 others, Ramalingam, S. S., Burns, T. F., Meric-Bernstam, F., Henary, H., Ngang, J., Ngarmchamnanrith, G., Kim, J., Houk, B. E., Canon, J., Russell Lipford, J., Friberg, G., Lito, P., Govindan, R. & Li, B. T., Sep 24 2020, In: New England Journal of Medicine. 383, 13, p. 1207-1217 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1064 Scopus citations

Long non-coding RNA LCAL62 / LINC00261 is associated with lung adenocarcinoma prognosis

Dang, H. X., White, N. M., Rozycki, E. B., Felsheim, B. M., Watson, M. A., Govindan, R., Luo, J. & Maher, C. A., Mar 2020, In: Heliyon. 6, 3, e03521.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

Multi-Institutional Prospective Validation of Prognostic mRNA Signatures in Early Stage Squamous Lung Cancer (Alliance)

Bueno, R., Richards, W. G., Harpole, D. H., Ballman, K. V., Tsao, M. S., Chen, Z., Wang, X., Chen, G., Chirieac, L. R., Chui, M. H., Franklin, W. A., Giordano, T. J., Govindan, R., Joshi, M. B., Merrick, D. T., Rivard, C. J., Sporn, T., van Bokhoven, A., Yu, H. & Shepherd, F. A. & 3 others, Watson, M. A., Beer, D. G. & Hirsch, F. R., Nov 2020, In: Journal of Thoracic Oncology. 15, 11, p. 1748-1757 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

22 Scopus citations

Pan-cancer analysis of whole genomes

The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium, Feb 6 2020, In: Nature. 578, 7793, p. 82-93 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1699 Scopus citations

Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition

PCAWG-Structural Variation Working Group & PCAWG Consortium, Mar 1 2020, In: Nature Genetics. 52, 3, p. 306-319 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

241 Scopus citations

Pathway and network analysis of more than 2500 whole cancer genomes

PCAWG Drivers and Functional Interpretation Working Group & PCAWG Consortium, Dec 1 2020, In: Nature communications. 11, 1, 729.

Research output: Contribution to journal › Article › peer-review

Open Access

68 Scopus citations

Pooled overall survival and safety data from the pivotal phase II studies (NP28673 and NP28761) of alectinib in ALK-positive non-small-cell lung cancer

Ou, S. H. I., Gadgeel, S. M., Barlesi, F., Yang, J. C. H., De Petris, L., Kim, D. W., Govindan, R., Dingemans, A. M., Crino, L., Léna, H., Popat, S., Ahn, J. S., Dansin, E., Mitry, E., Müller, B., Bordogna, W., Balas, B., Morcos, P. N. & Shaw, A. T., Jan 2020, In: Lung Cancer. 139, p. 22-27 6 p.

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma

Clinical Proteomic Tumor Analysis Consortium, Jul 9 2020, In: Cell. 182, 1, p. 200-225.e35

Research output: Contribution to journal › Article › peer-review

Open Access

400 Scopus citations

Quality of life with second or third line nab-paclitaxel-based regimens in advanced non-small-cell lung cancer

Ponce Aix, S., Talbot, D., Govindan, R., Dols, M. C., Postmus, P. E., Lewanski, C., Bennouna, J., Fischer, J. R., Juan-Vidal, O., Stewart, D. J., Ardizzoni, A., Bhore, R., Wolfsteiner, M., Reck, M., Ong, T. J. & Morgensztern, D., Apr 2020, In: Future Oncology. 16, 12, p. 749-762 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig

PCAWG Evolution and Heterogeneity Working Group & PCAWG Consortium, Dec 1 2020, In: Nature communications. 11, 1, 731.

Research output: Contribution to journal › Article › peer-review

Open Access

29 Scopus citations

Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples

MC3 Working Group, PCAWG novel somatic mutation calling methods working group & PCAWG Consortium, Dec 1 2020, In: Nature communications. 11, 1, 4748.

Research output: Contribution to journal › Article › peer-review

Open Access

27 Scopus citations

Sex differences in oncogenic mutational processes

PCAWG Tumour Subtypes and Clinical Translation & PCAWG Consortium, Dec 1 2020, In: Nature communications. 11, 1, 4330.

Research output: Contribution to journal › Article › peer-review

Open Access

59 Scopus citations

Systematic establishment of robustness and standards in patient-derived xenograft experiments and analysis

NCI PDXNet Consortium, Jun 2020, In: Cancer research. 80, 11, p. 2286-2297 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

36 Scopus citations

The landscape of viral associations in human cancers

PCAWG Pathogens & PCAWG Consortium, Mar 1 2020, In: Nature Genetics. 52, 3, p. 320-330 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

240 Scopus citations

Whole exome sequencing of highly aggregated lung cancer families reveals linked loci for increased cancer risk on chromosomes 12q, 7p, and 4q

Musolf, A. M., Moiz, B. A., Sun, H., Pikielny, C. W., Bosse, Y., Mandal, D., De Andrade, M., Gaba, C., Yang, P., Li, Y., You, M., Govindan, R., Wilson, R. K., Kupert, E. Y., Anderson, M. W., Schwartz, A. G., Pinney, S. M., Amos, C. I. & Bailey-Wilson, J. E., Feb 1 2020, In: Cancer Epidemiology Biomarkers and Prevention. 29, 2, p. 434-442 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

2019

Accounting for proximal variants improves neoantigen prediction

Hundal, J., Kiwala, S., Feng, Y. Y., Liu, C. J., Govindan, R., Chapman, W. C., Uppaluri, R., Swamidass, S. J., Griffith, O. L., Mardis, E. R. & Griffith, M., Jan 1 2019, In: Nature Genetics. 51, 1, p. 175-179 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

35 Scopus citations

Circulating tumor DNA profiling in small-cell lung cancer identifies potentially targetable alterations

Devarakonda, S., Sankararaman, S., Herzog, B. H., Gold, K. A., Waqar, S. N., Ward, J. P., Raymond, V. M., Lanman, R. B., Chaudhuri, A. A., Owonikoko, T. K., Li, B. T., Poirier, J. T., Rudin, C. M., Govindan, R. & Morgensztern, D., Oct 15 2019, In: Clinical Cancer Research. 25, 20, p. 6119-6126 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

34 Scopus citations

Correlation of PD-L1 Expression with Tumor Mutation Burden and Gene Signatures for Prognosis in Early-Stage Squamous Cell Lung Carcinoma

Yu, H., Chen, Z., Ballman, K. V., Watson, M. A., Govindan, R., Lanc, I., Beer, D. G., Bueno, R., Chirieac, L. R., Chui, M. H., Chen, G., Franklin, W. A., Gandara, D. R., Genova, C., Brovsky, K. A., Joshi, M. B. M., Merrick, D. T., Richards, W. G., Rivard, C. J. & Harpole, D. H. & 4 others, Tsao, M. S., van Bokhoven, A., Shepherd, F. A. & Hirsch, F. R., Jan 2019, In: Journal of Thoracic Oncology. 14, 1, p. 25-36 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

64 Scopus citations

Efficacy and safety of rovalpituzumab tesirine in third-line and beyond patients with DLL3-expressing, relapsed/refractory small-cell lung cancer: Results from the phase II TrINITY study

Morgensztern, D., Besse, B., Greillier, L., Santana-Davila, R., Ready, N., Hann, C. L., Glisson, B. S., Farago, A. F., Dowlati, A., Rudin, C. M., Le Moulec, S., Lally, S., Yalamanchili, S., Wolf, J., Govindan, R. & Carbone, D. P., Dec 1 2019, In: Clinical Cancer Research. 25, 23, p. 6958-6966 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

211 Scopus citations

Healthcare resource utilization and associated cost analysis of the PROCLAIM study in patients with stage III non-small-cell lung cancer

Govindan, R., Senan, S., Dickgreber, N., Provencio, M., Wu, Y. L., Syrigos, K., Parente, B., Wilson, M., Ziemiecki, R., Chouaki, N., Hossain, A., San Antonio, B., Winfree, K. & Vokes, E. E., Oct 3 2019, In: Current Medical Research and Opinion. 35, 10, p. 1761-1767 7 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Multicenter phase I study of erdafitinib (JNJ-42756493), oral pan-fibroblast growth factor receptor inhibitor, in patients with advanced or refractory solid tumors

Bahleda, R., Italiano, A., Hierro, C., Mita, A., Cervantes, A., Chan, N., Awad, M., Calvo, E., Moreno, V., Govindan, R., Spira, A., Gonzalez, M., Zhong, B., Santiago-Walker, A., Poggesi, I., Parekh, T., Xie, H., Infante, J. & Tabernero, J., Aug 15 2019, In: Clinical Cancer Research. 25, 16, p. 4888-4897 10 p.

Research output: Contribution to journal › Article › peer-review

197 Scopus citations

Non-small cell lung cancer, version 1.2020: Featured updates to the NCCN guidelines

Ettinger, D. S., Wood, D. E., Aggarwal, C., Aisner, D. L., Akerley, W., Bauman, J. R., Bharat, A., Bruno, D. S., Chang, J. Y., Chirieac, L. R., D'Amico, T. A., Dilling, T. J., Dobelbower, M., Gettinger, S., Govindan, R., Gubens, M. A., Hennon, M., Horn, L., Lackner, R. P. & Lanuti, M. & 16 others, Leal, T. A., Lin, J., Loo, B. W., Martins, R. G., Otterson, G. A., Patel, S. P., Reckamp, K. L., Riely, G. J., Schild, S. E., Shapiro, T. A., Stevenson, J., Swanson, S. J., Tauer, K. W., Yang, S. C., Gregory, K. & Hughes, M., 2019, In: JNCCN Journal of the National Comprehensive Cancer Network. 17, 12, p. 1464-1472 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

566 Scopus citations

Open-sourced CIViC annotation pipeline to identify and annotate clinically relevant variants using single-molecule molecular inversion probes

Barnell, E. K., Waalkes, A., Mosior, M. C., Penewit, K., Cotto, K. C., Danos, A. M., Sheta, L. M., Campbell, K. M., Krysiak, K., Rieke, D., Spies, N. C., Skidmore, Z. L., Pritchard, C. C., Fehniger, T. A., Uppaluri, R., Govindan, R., Griffith, M., Salipante, S. J. & Griffith, O. L., 2019, In: JCO Clinical Cancer Informatics. 3, p. 1-12 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Phase I, Open-Label, Dose-Escalation Study of the Safety, Pharmacokinetics, Pharmacodynamics, and Efficacy of GSK2879552 in Relapsed/Refractory SCLC

Bauer, T. M., Besse, B., Martinez-Marti, A., Trigo, J. M., Moreno, V., Garrido, P., Ferron-Brady, G., Wu, Y., Park, J., Collingwood, T., Kruger, R. G., Mohammad, H. P., Ballas, M. S., Dhar, A. & Govindan, R., Oct 2019, In: Journal of Thoracic Oncology. 14, 10, p. 1828-1838 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

56 Scopus citations

Phase II Study of Roniciclib in Combination with Cisplatin/Etoposide or Carboplatin/Etoposide as First-Line Therapy in Patients with Extensive-Disease Small Cell Lung Cancer

Reck, M., Horn, L., Novello, S., Barlesi, F., Albert, I., Juhász, E., Kowalski, D., Robinet, G., Cadranel, J., Bidoli, P., Chung, J., Fritsch, A., Drews, U., Wagner, A. & Govindan, R., Apr 2019, In: Journal of Thoracic Oncology. 14, 4, p. 701-711 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

44 Scopus citations

Prospective clinical validation of the invisionfirst-lung circulating tumor DNA assay for molecular profiling of patients with advanced nonsquamous non–small-cell lung cancer

Pritchett, M. A., Camidge, D. R., Patel, M., Khatri, J., Boniol, S., Friedman, E. K., Khomani, A., Dalia, S., Baker-Neblett, K., Plagnol, V., Howarth, K. D., Jones, G. R., Rosenfeld, N., Morris, C. D. & Govindan, R., 2019, In: JCO Precision Oncology. 3, p. 1-15 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

32 Scopus citations

Select: A phase II trial of adjuvant erlotinib in patients with resected epidermal growth factor receptor-mutant non-small-cell lung cancer

Pennell, N. A., Neal, J. W., Chaft, J. E., Azzoli, C. G., Jänne, P. A., Govindan, R., Evans, T. L., Costa, D. B., Wakelee, H. A., Heist, R. S., Shapiro, M. A., Muzikansky, A., Murthy, S., Lanuti, M., Rusch, V. W., Kris, M. G. & Sequist, L. V., Jan 10 2019, In: Journal of Clinical Oncology. 37, 2, p. 97-104 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

163 Scopus citations

The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity

Canon, J., Rex, K., Saiki, A. Y., Mohr, C., Cooke, K., Bagal, D., Gaida, K., Holt, T., Knutson, C. G., Koppada, N., Lanman, B. A., Werner, J., Rapaport, A. S., San Miguel, T., Ortiz, R., Osgood, T., Sun, J. R., Zhu, X., McCarter, J. D. & Volak, L. P. & 14 others, Houk, B. E., Fakih, M. G., O’Neil, B. H., Price, T. J., Falchook, G. S., Desai, J., Kuo, J., Govindan, R., Hong, D. S., Ouyang, W., Henary, H., Arvedson, T., Cee, V. J. & Lipford, J. R., Nov 7 2019, In: Nature. 575, 7781, p. 217-223 7 p.

Research output: Contribution to journal › Article › peer-review

1367 Scopus citations

2018

ABOUND.2L+: A randomized phase 2 study of nanoparticle albumin-bound paclitaxel with or without CC-486 as second-line treatment for advanced nonsquamous non-small cell lung cancer (NSCLC)

on behalf of the ABOUND.2L+ Investigators, Dec 15 2018, In: Cancer. 124, 24, p. 4667-4675 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers

The Cancer Genome Atlas Research Network, Apr 9 2018, In: Cancer Cell. 33, 4, p. 690-705.e9

Research output: Contribution to journal › Article › peer-review

Open Access

404 Scopus citations

A deep learning approach to automate refinement of somatic variant calling from cancer sequencing data

Ainscough, B. J., Barnell, E. K., Ronning, P., Campbell, K. M., Wagner, A. H., Fehniger, T. A., Dunn, G. P., Uppaluri, R., Govindan, R., Rohan, T. E., Griffith, M., Mardis, E. R., Swamidass, S. J. & Griffith, O. L., Dec 1 2018, In: Nature Genetics. 50, 12, p. 1735-1743 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access