Research output per year
Research output per year
Personal profile
Research interests
Our group is interested in developing predictive and prognostic biomarkers in patients with non-small cell lung cancer(NSCLC). We have identified a 64 gene signature that accurately predicts the outcomes of patients with resected early stage NSCLC. We are in the process of developing a q RT PCR assay that could be performed in formalin fixed paraffin embedded tissues. We are also pursuing genomic predictors of recurrence in the brain as brain metastases from NSCLC is a major cause of morbidity and mortality. We are actively studying distinctive molecular changes associated with lung cancer in lifelong never smokers. Finally, our group is interested in exploring novel agents in the treatment of advanced NSCLC.
Clinical interests
Esophageal, thoracic and lung cancer
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Collaborations and top research areas from the last five years
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AI-guided histopathology predicts brain metastasis in lung cancer patients
Zhou, H., Watson, M., Bernadt, C. T., Lin, S., Lin, C. Y., Ritter, J. H., Wein, A., Mahler, S., Rawal, S., Govindan, R., Yang, C. & Cote, R. J., May 2024, In: Journal of Pathology. 263, 1, p. 89-98 10 p.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
A Pan-Cancer Patient-Derived Xenograft Histology Image Repository with Genomic and Pathologic Annotations Enables Deep Learning Analysis
PDXNET Consortium, Jul 1 2024, In: Cancer research. 84, 13, p. 2060-2072 13 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
A pilot study of nintedanib in molecularly selected patients with advanced non-small cell lung cancer
Auberle, C., Gao, F., Sloan, M., Morgensztern, D., Winkler, L., Ward, J. P., Devarakonda, S., Rearden, T. P., Govindan, R. & Waqar, S. N., Jun 30 2024, In: Journal of Thoracic Disease. 16, 6, p. 3782-3793 12 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Combined KRAS-MAPK pathway inhibitors and HER2-directed drug conjugate is efficacious in pancreatic cancer
Bulle, A., Liu, P., Seehra, K., Bansod, S., Chen, Y., Zahra, K., Somani, V., Khawar, I. A., Chen, H. P., Dodhiawala, P. B., Li, L., Geng, Y., Mo, C. K., Mahsl, J., Ding, L., Govindan, R., Davies, S., Mudd, J., Hawkins, W. G. & Fields, R. C. & 7 others, , Dec 2024, In: Nature communications. 15, 1, 2503.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
Corrigendum: Translatability of findings from cynomolgus monkey to human suggests a mechanistic role for IL-21 in promoting immunogenicity to an anti-PD-1/IL-21 mutein fusion protein(Front. Immunol., (2024), 15, (1345473), 10.3389/fimmu.2024.1345473)
Kroenke, M. A., Manning, M. S., Zuch de Zafra, C. L., Zhang, X., Cook, K. D., Archer, M., Lolkema, M. P., Wang, J., Hoofring, S., Saini, G., Aeffner, F., Ahern, E., Cabanas, E. G., Govindan, R., Hui, M., Gupta, S. & Mytych, D. T., 2024, In: Frontiers in immunology. 15, 1441999.Research output: Contribution to journal › Comment/debate
Open Access