Rajan Sah

Associate Professor of Medicine, Associate Professor of Cell Biology and Physiology

    • 1871 Citations
    19962020

    Research output per year

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    Personal profile

    Research interests

    I am a physician-scientist cardiologist in the Department of Internal Medicine at Washington University in St. Louis and Center for Cardiovascular Research. My passion is to discover, develop and deliver better therapies for patients with cardiovascular disease. To this end I have directed my research efforts to identifying novel and innovative biological targets to open new, untested therapeutic avenues. A major goal of my laboratory is to study the function of novel ion channels; specifically TRP channels (including TRPV3, TRPV4 and TRPM7), and the recently identified volume regulatory anion channel SWELL1 (LRRC8a) as they relate to growth and metabolism. To do this we combine cellular electrophysiology, calcium imaging (GCaMP6) and novel genetic techniques (including transient and stable lenti/AAV-shRNA-mediated knockdown and CRISPR-mediated knockout) in cultured cells (mouse and human) and freshly isolated, primary adipocytes, pancreatic ß-cells, hepatocytes, skeletal myocytes, and endothelium. Genetic loss-of-function (CRISPR-mediated and conventional) mouse models for these ion channels are also used to examine their functions in vivo and in disease settings. By taking a “wide-angle” view of ion channel signaling in biology, my laboratory has established several new independent research directions (in part through collaborative relationships) that emanates from our findings and leverages unique molecular tools and skill sets established in our laboratory.

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    Research Output

    LRRC8A-dependent volume-regulated anion channels contribute to ischemia-induced brain injury and glutamatergic input to hippocampal neurons

    Zhou, J. J., Luo, Y., Chen, S. R., Shao, J. Y., Sah, R. & Pan, H. L., Oct 2020, In : Experimental Neurology. 332, 113391.

    Research output: Contribution to journalArticle

  • Mechanism and effects of pulsatile GABA secretion from cytosolic pools in the human beta cell

    Menegaz, D., Hagan, D. W., Almaça, J., Cianciaruso, C., Rodriguez-Diaz, R., Molina, J., Dolan, R. M., Becker, M. W., Schwalie, P. C., Nano, R., Lebreton, F., Kang, C., Sah, R., Gaisano, H. Y., Berggren, P. O., Baekkeskov, S., Caicedo, A. & Phelps, E. A., Nov 1 2019, In : Nature Metabolism. 1, 11, p. 1110-1126 17 p.

    Research output: Contribution to journalArticle

  • 7 Scopus citations

    Role of diabetes and insulin use in the risk of stroke and acute myocardial infarction in patients with atrial fibrillation: A Medicare analysis

    Mentias, A., Shantha, G., Adeola, O., Barnes, G. D., Narasimhan, B., Siontis, K. C., Levine, D. A., Sah, R., Giudici, M. C. & Vaughan Sarrazin, M., Aug 2019, In : American heart journal. 214, p. 158-166 9 p.

    Research output: Contribution to journalArticle

  • 4 Scopus citations

    SWELL signalling in adipocytes: can fat 'feel' fat?

    Gunasekar, S. K., Xie, L. & Sah, R., Jan 2 2019, In : Adipocyte. 8, 1, p. 223-228 6 p.

    Research output: Contribution to journalComment/debate

    Open Access
  • 2 Scopus citations

    SWELL1 is a glucose sensor regulating β-cell excitability and systemic glycaemia

    Kang, C., Xie, L., Gunasekar, S. K., Mishra, A., Zhang, Y., Pai, S., Gao, Y., Kumar, A., Norris, A. W., Stephens, S. B. & Sah, R., Dec 1 2018, In : Nature communications. 9, 1, 367.

    Research output: Contribution to journalArticle

    Open Access
  • 26 Scopus citations