Rafael Galindo

Assistant Professor of Neurology

    • 380 Citations
    19952020

    Research output per year

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    Personal profile

    Research interests

    The focus of my neuroscientific research involves exploring novel neuroprotective strategies and understanding neurobiological mechanisms that regulate neuronal survival and death in the injured neonatal brain. Specifically, I have been examining the role and associated cellular mechanisms of Nicotinamide Mononucleotide Adenylyltransferases (NMNATs), sterile alpha- and armadillo-motif-containing protein (SARM) and human Chorionic Gonadotropin (hCG) receptor in maintaining neuronal survival of injured developing neurons and brain. Understanding the role of these proteins on the survival of injured immature neurons may offer new potential agents and/or cellular targets for the effective treatment and prevention of the immediate and long-term neurological consequences that affect neonates exposed to birth asphyxia. We are also developing new function-based animal models for the systematic evaluation of the neurological comorbidities associated with neonatal cerebral injury. To this end, we are developing new technologies and methods for evaluating cortical network connectivity and seizures during and/or following neonatal ischemia.

    Areas of Clinical Interest

    pediatric neurology, intensive care of newborns, congenital neurological conditions,

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    Research Output

    • 380 Citations
    • 17 Article

    Early developmental electroencephalography abnormalities, neonatal seizures, and induced spasms in a mouse model of tuberous sclerosis complex

    Rensing, N., Johnson, K. J., Foutz, T. J., Friedman, J. L., Galindo, R. & Wong, M., May 1 2020, In : Epilepsia. 61, 5, p. 879-891 13 p.

    Research output: Contribution to journalArticle

  • 1 Scopus citations

    Longitudinal analysis of developmental changes in electroencephalography patterns and sleep-wake states of the neonatal mouse

    Rensing, N., Moy, B., Friedman, J. L., Galindo, R. & Wong, M., Nov 2018, In : PloS one. 13, 11, e0207031.

    Research output: Contribution to journalArticle

    Open Access
  • 6 Scopus citations

    NMNAT3 is protective against the effects of neonatal cerebral hypoxia-ischemia

    Galindo, R., Banks Greenberg, M., Araki, T., Sasaki, Y., Mehta, N., Milbrandt, J. & Holtzman, D. M., Oct 2017, In : Annals of Clinical and Translational Neurology. 4, 10, p. 722-738 17 p.

    Research output: Contribution to journalArticle

    Open Access
  • 1 Scopus citations

    Pretreatment with human chorionic gonadotropin Protects the neonatal Brain against the effects of hypoxic-ischemic injury

    Movsas, T. Z., Weiner, R. L., Greenberg, M. B., Holtzman, D. M. & Galindo, R., Nov 3 2017, In : Frontiers in Pediatrics. 5, 232.

    Research output: Contribution to journalArticle

    Open Access
  • 6 Scopus citations

    Actions of acute and chronic ethanol on presynaptic terminals

    Roberto, M., Treistman, S. N., Pietrzykowski, A. Z., Weiner, J., Galindo, R., Mameli, M., Valenzuela, F., Zhu, P. J., Lovinger, D., Zhang, T. A., Hendricson, A. H., Morrisett, R. & Siggins, G. R., Feb 2006, In : Alcoholism: Clinical and Experimental Research. 30, 2, p. 222-232 11 p.

    Research output: Contribution to journalArticle

  • 36 Scopus citations