R Reid Townsend

2013

Quantitative Label-Free Proteomics for Discovery of Biomarkers in Cerebrospinal Fluid: Assessment of Technical and Inter-Individual Variation

Perrin, R. J., Payton, J. E., Malone, J. P., Gilmore, P., Davis, A. E., Xiong, C., Fagan, A. M., Townsend, R. R. & Holtzman, D. M., May 20 2013, In: PloS one. 8, 5, e64314.

Research output: Contribution to journal › Article › peer-review

Open Access

28 Scopus citations

Single Point Mutations Result in the Miss-Sorting of Glut4 to a Novel Membrane Compartment Associated with Stress Granule Proteins

Song, X. M., Lichti, C. F., Townsend, R. R. & Mueckler, M., Jul 16 2013, In: PloS one. 8, 7, e68516.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

2012

Alterations in protein regulators of neurodevelopment in the cerebrospinal fluid of infants with posthemorrhagic hydrocephalus of prematurity

Morales, D. M., Townsend, R. R., Malone, J. P., Ewersmann, C. A., Macy, E. M., Inder, T. E. & Limbrick, D. D., Jun 2012, In: Molecular and Cellular Proteomics. 11, 6

Research output: Contribution to journal › Article › peer-review

Open Access

28 Scopus citations

A neurosteroid analogue photolabeling reagent labels the colchicine-binding site on tubulin: A mass spectrometric analysis

Chen, Z. W., Chen, L. H., Akentieva, N., Lichti, C. F., Darbandi, R., Hastings, R., Covey, D. F., Reichert, D. E., Townsend, R. R. & Evers, A. S., Feb 2012, In: Electrophoresis. 33, 4, p. 666-674 9 p.

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Deep amino acid sequencing of native brain GABA_A receptors using high-resolution mass spectrometry

Chen, Z. W., Fuchs, K., Sieghart, W., Townsend, R. R. & Evers, A. S., Jan 2012, In: Molecular and Cellular Proteomics. 11, 1

Research output: Contribution to journal › Article › peer-review

Open Access

31 Scopus citations

Identification of potential mediators of retinotopic mapping: A comparative proteomic analysis of optic nerve from WT and Phr1 retinal knockout mice

Lee, A. R., Lamb, R. R., Chang, J. H., Erdmann-Gilmore, P., Lichti, C. F., Rohrs, H. W., Malone, J. P., Wairkar, Y. P., Diantonio, A., Townsend, R. R. & Culican, S. M., Nov 2 2012, In: Journal of Proteome Research. 11, 11, p. 5515-5526 12 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Mass spectrometry-based identification of native cardiac Nav1.5 channel α subunit phosphorylation sites

Marionneau, C., Lichti, C. F., Lindenbaum, P., Charpentier, F., Nerbonne, J. M., Townsend, R. R. & Mérot, J., Dec 7 2012, In: Journal of Proteome Research. 11, 12, p. 5994-6007 14 p.

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Multiplex proteomics analysis of gender-associated proteins in Brugia malayi

Jiang, D., Malone, J., Townsend, R., Weil, G. J. & Li, B., Aug 2012, In: International Journal for Parasitology. 42, 9, p. 841-850 10 p.

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Neurosteroid analog photolabeling of a site in the third transmembrane domain of the β3 subunit of the GABA_A receptor

Chen, Z. W., Manion, B., Townsend, R. R., Reichert, D. E., Covey, D. F., Steinbach, J. H., Sieghart, W., Fuchs, K. & Evers, A. S., Sep 2012, In: Molecular pharmacology. 82, 3, p. 408-419 12 p.

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

The role of molecular chaperonins in warm ischemia and reperfusion injury in the steatotic liver: A proteomic study

Tiriveedhi, V., Conzen, K. D., Liaw-Conlin, J., Upadhya, G., Malone, J., Townsend, R. R., Kerns, R., Jia, J., Csontos, K., Ramachandran, S., Mohanakumar, T., Anderson, C. D. & Chapman, W. C., 2012, In: BMC Biochemistry. 13, 1, 17.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

The sodium channel accessory subunit Navβ1 regulates neuronal excitability through modulation of repolarizing Voltage-gated K⁺ channels

Marionneau, C., Carrasquillo, Y., Norris, A. J., Reid Townsend, R., Isom, L. L., Link, A. J. & Nerbonne, J. M., Apr 25 2012, In: Journal of Neuroscience. 32, 17, p. 5716-5727 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

65 Scopus citations

2011

A bioinformatics approach for biomarker identification in radiation-induced lung inflammation from limited proteomics data

Oh, J. H., Craft, J. M., Townsend, R., Deasy, J. O., Bradley, J. D. & El Naqa, I., Mar 4 2011, In: Journal of Proteome Research. 10, 3, p. 1406-1415 10 p.

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Cross-species comparison of orthologous gene expression in human bladder cancer and carcinogen-induced rodent models

Lu, Y., Liu, P., Wen, W., Grubbs, C. J., Townsend, R. R., Malone, J. P., Lubet, R. A. & You, M., 2011, In: American Journal of Translational Research. 3, 1, p. 8-27 20 p.

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Efficacy of the EGFr inhibitor Iressa on development of chemically-induced urinary bladder cancers: Dose dependency and modulation of biomarkers

Lubet, R. A., Lu, Y., Bode, A. M., You, M., Verney, Z. M., Steele, V. E., Townsend, R., Juliana, M. M. & Grubbs, C. J., May 2011, In: Oncology reports. 25, 5, p. 1389-1397 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

Identification and Validation of Novel Cerebrospinal Fluid Biomarkers for Staging Early Alzheimer's Disease

Perrin, R. J., Craig-Schapiro, R., Malone, J. P., Shah, A. R., Gilmore, P., Davis, A. E., Roe, C. M., Peskind, E. R., Li, G., Galasko, D. R., Clark, C. M., Quinn, J. F., Kaye, J. A., Morris, J. C., Holtzman, D. M., Townsend, R. & Fagan, A. M., 2011, In: PloS one. 6, 1, e16032.

Research output: Contribution to journal › Article › peer-review

Open Access

136 Scopus citations

Identification of CaMKII phosphorylation sites in connexin43 by high-resolution mass spectrometry

Huang, R. Y. C., Laing, J. G., Kanter, E. M., Berthoud, V. M., Bao, M., Rohrs, H. W., Townsend, R. R. & Yamada, K. A., Mar 4 2011, In: Journal of Proteome Research. 10, 3, p. 1098-1109 12 p.

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Identification of FUSE-binding protein 1 as a regulatory mRNA-binding protein that represses nucleophosmin translation

Olanich, M. E., Moss, B. L., Piwnica-Worms, D., Townsend, R. R. & Weber, J. D., Jan 6 2011, In: Oncogene. 30, 1, p. 77-86 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

32 Scopus citations

Identification of in vitro autophosphorylation sites and effects of phosphorylation on the arabidopsis CRINKLY4 (ACR4) receptor-like kinase intracellular domain: Insights into conformation, oligomerization, and activity

Meyer, M. R., Lichti, C. F., Townsend, R. R. & Rao, A. G., Mar 29 2011, In: Biochemistry. 50, 12, p. 2170-2186 17 p.

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Inhibition of lens photodamage by UV-absorbing contact lenses

Andley, U. P., Malone, J. P. & Reid Townsend, R., Oct 2011, In: Investigative Ophthalmology and Visual Science. 52, 11, p. 8330-8341 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Scopus citations

Proteomic analysis highlights the molecular complexities of native Kv4 channel macromolecular complexes

Marionneau, C., Townsend, R. R. & Nerbonne, J. M., Apr 2011, In: Seminars in Cell and Developmental Biology. 22, 2, p. 145-152 8 p.

Research output: Contribution to journal › Review article › peer-review

18 Scopus citations

Residual Cx45 and its relationship to Cx43 in Murine ventricular myocardium

Bao, M., Kanter, E. M., Huang, R. Y. C., Maxeiner, S., Frank, M., Zhang, Y., Schuessler, R. B., Smith, T. W., Townsend, R. R., Rohrs, H. W., Berthoud, V. M., Willecke, K., Laing, J. G. & Yamada, K. A., 2011, In: Channels. 5, 6

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

RNA helicase DDX5 is a p53-independent target of ARF that participates in ribosome biogenesis

Saporita, A. J., Chang, H. C., Winkeler, C. L., Apicelli, A. J., Kladney, R. D., Wang, J., Townsend, R. R., Michel, L. S. & Weber, J. D., Nov 1 2011, In: Cancer research. 71, 21, p. 6708-6717 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

41 Scopus citations

2010

Airway proteins involved in bacterial clearance susceptible to cathepsin G proteolysis

Farberman, M. M., Akers, K. T., Malone, J. P., Erdman-Gilmore, P., Townsend, R. R. & Ferkol, T., Feb 2010, In: European Respiratory Journal. 35, 2, p. 410-417 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

DNMT3A mutations in acute myeloid leukemia

Ley, T. J., Ding, L., Walter, M. J., McLellan, M. D., Lamprecht, T., Larson, D. E., Kandoth, C., Payton, J. E., Baty, J., Welch, J., Harris, C. C., Lichti, C. F., Townsend, R. R., Fulton, R. S., Dooling, D. J., Koboldt, D. C., Schmidt, H., Zhang, Q., Osborne, J. R., Lin, L. & 28 others, O'Laughlin, M., McMichael, J. F., Delehaunty, K. D., McGrath, S. D., Fulton, L. A., Magrini, V. J., Vickery, T. L., Hundal, J., Cook, L. L., Conyers, J. J., Swift, G. W., Reed, J. P., Alldredge, P. A., Wylie, T., Walker, J., Kalicki, J., Watson, M. A., Heath, S., Shannon, W. D., Varghese, N., Nagarajan, R., Westervelt, P., Tomasson, M. H., Link, D. C., Graubert, T. A., DiPersio, J. F., Mardis, E. R. & Wilson, R. K., Dec 16 2010, In: New England Journal of Medicine. 363, 25, p. 2424-2433 10 p.

Research output: Contribution to journal › Article › peer-review

1412 Scopus citations

Hsp 70/Hsp 90 organizing protein as a nitrosylation target in cystic fibrosis therapy

Marozkina, N. V., Yemen, S., Borowitz, M., Liu, L., Plapp, M., Sun, F., Islam, R., Erdmann-Gilmore, P., Townsend, R. R., Lichti, C. F., Mantri, S., Clapp, P. W., Randell, S. H., Gaston, B. & Zaman, K., Jun 22 2010, In: Proceedings of the National Academy of Sciences of the United States of America. 107, 25, p. 11393-11398 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

57 Scopus citations

Phosphorylation of immunity-related GTPases by a toxoplasma gondii-secreted kinase promotes macrophage survival and virulence

Fentress, S. J., Behnke, M. S., Dunay, I. R., Mashayekhi, M., Rommereim, L. M., Fox, B. A., Bzik, D. J., Taylor, G. A., Turk, B. E., Lichti, C. F., Townsend, R. R., Qiu, W., Hui, R., Beatty, W. L. & Sibley, L. D., Dec 16 2010, In: Cell Host and Microbe. 8, 6, p. 484-495 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

211 Scopus citations

Revealing novel telomere proteins using in vivo cross-linking, tandem affinity purification, and label-free quantitative LC-FTICR-MS

Nittis, T., Guittat, L., LeDuc, R. D., Dao, B., Duxin, J. P., Rohrs, H., Townsend, R. R. & Stewart, S. A., Jun 2010, In: Molecular and Cellular Proteomics. 9, 6, p. 1144-1156 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

43 Scopus citations

Serum markers may distinguish biliary atresia from other forms of neonatal cholestasis

Wang, H., Malone, J. P., Gilmore, P. E., Davis, A. E., Magee, J. C., Townsend, R. R. & Heuckeroth, R. O., Apr 2010, In: Journal of pediatric gastroenterology and nutrition. 50, 4, p. 411-416 6 p.

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

The haemophilus influenzae HMW1c protein is a glycosyltransferase that transfers hexose residues to asparagine sites in the HMW1 adhesin

Grass, S., Lichti, C. F., Townsend, R. R., Gross, J. & St. Geme, J. W., May 2010, In: PLoS pathogens. 6, 5, p. 1-9 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

80 Scopus citations

YKL-40: A novel prognostic fluid biomarker for preclinical Alzheimer's disease

Craig-Schapiro, R., Perrin, R. J., Roe, C. M., Xiong, C., Carter, D., Cairns, N. J., Mintun, M. A., Peskind, E. R., Li, G., Galasko, D. R., Clark, C. M., Quinn, J. F., D'Angelo, G., Malone, J. P., Townsend, R. R., Morris, J. C., Fagan, A. M. & Holtzman, D. M., Nov 15 2010, In: Biological Psychiatry. 68, 10, p. 903-912 10 p.

Research output: Contribution to journal › Article › peer-review

272 Scopus citations

2009

Erratum: Mechanism of small heat shock protein function in vivo. A knock-in mouse model demonstrates that the R49C mutation in αA-crystallin enhances protein insolubility and cell death (The Journal of Biological Chemistry (2008) vol. 283 (5801-5814) 10.1074/ A708704200)

Xi, J. H., Bai, F., Gross, J., Townsend, R. R., Menko, A. S. & Andley, U. P., Dec 18 2009, In: Journal of Biological Chemistry. 284, 51, p. 35996 1 p.

Research output: Contribution to journal › Comment/debate

Open Access

Proteomic analyses of native brain K_V4.2 channel complexes

Marionneau, C., LeDuc, R. D., Rohrs, H. W., Link, A. J., Townsend, R. R. & Nerbonne, J. M., 2009, In: Channels. 3, 4

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Proteomic analysis of anoxia tolerance in the developing zebrafish embryo

Mendelsohn, B. A., Malone, J. P., Townsend, R. R. & Gitlin, J. D., Mar 2009, In: Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics. 4, 1, p. 21-31 11 p.

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Proteomic comparison of Entamoeba histolytica and Entamoeba dispar and the role of E. histolytica alcohol dehydrogenase 3 in virulence

Davis, P. H., Chen, M., Zhang, X., Clark, C. G., Townsend, R. R. & Stanley, S. L., 2009, In: PLoS neglected tropical diseases. 3, 4, e415.

Research output: Contribution to journal › Article › peer-review

Open Access

26 Scopus citations

The asialoglycoprotein receptor regulates levels of plasma glycoproteins terminating with sialic acid α2,6-galactose

Steirer, L. M., Park, E. I., Townsend, R. R. & Baenzinger, J. U., Feb 6 2009, In: Journal of Biological Chemistry. 284, 6, p. 3777-3783 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

67 Scopus citations

Urinary cysteinyl leukotriene E₄ significantly increases during pain in children and adults with sickle cell disease

Field, J. J., Strunk, R. C., Knight-Perry, J. E., Blinder, M. A., Townsend, R. R. & DeBaun, M. R., Apr 2009, In: American journal of hematology. 84, 4, p. 231-233 3 p.

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

2008

A unified sample preparation protocol for proteomic and genomic profiling of cervical swabs to identify biomarkers for cervical cancer screening

Rader, J. S., Malone, J. P., Gross, J., Gilmore, P., Brooks, R. A., Nguyen, L., Crimmins, D. L., Feng, S., Wright, J. D., Taylor, N., Zighelboim, I., Funk, M. C., Huettner, P. C., Ledenson, J. H., Gius, D. & Townsend, R. R., 2008, In: Proteomics - Clinical Applications. 2, 12, p. 1658-1669 12 p.

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Carboxypeptidase E mediates palmitate-induced β-cell ER stress and apoptosis

Jeffrey, K. D., Alejandro, E. U., Luciani, D. S., Kalynyak, T. B., Hu, X., Li, H., Lin, Y., Townsend, R. R., Polonsky, K. S. & Johnson, J. D., Jun 17 2008, In: Proceedings of the National Academy of Sciences of the United States of America. 105, 24, p. 8452-8457 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

112 Scopus citations

Mechanism of small heat shock protein function in vivo: A knock-in mouse model demonstrates that the R49C mutation in αA-crystallin enhances protein insolubility and cell death

Xi, J. H., Bai, F., Gross, J., Townsend, R. R., Menko, A. S. & Andley, U. P., Feb 29 2008, In: Journal of Biological Chemistry. 283, 9, p. 5801-5814 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

50 Scopus citations

Nucleophosmin serves as a rate-limiting nuclear export chaperone for the mammalian ribosome

Maggi, L. B., Kuchenruether, M., Dadey, D. Y. A., Schwope, R. M., Grisendi, S., Townsend, R. R., Pandolfi, P. P. & Weber, J. D., Dec 2008, In: Molecular and cellular biology. 28, 23, p. 7050-7065 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

151 Scopus citations

The Haemophilus influenzae HMW1 adhesin is a glycoprotein with an unusual N-linked carbohydrate modification

Gross, J., Grass, S., Davis, A. E., Gilmore-Erdmann, P., Townsend, R. R. & St. Geme, J. W., Sep 19 2008, In: Journal of Biological Chemistry. 283, 38, p. 26010-26015 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

78 Scopus citations

2007

Identification and validation of novel CSF biomarkers for early stages of Alzheimer's disease

Hu, Y., Hosseini, A., Kauwe, J. S. K., Gross, J., Cairns, N. J., Goate, A. M., Fagan, A. M., Townsend, R. R. & Holtzman, D. M., Nov 2007, In: Proteomics - Clinical Applications. 1, 11, p. 1373-1384 12 p.

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Identification of protein phosphorylation sites within Ser/Thr-rich cluster domains using site-directed mutagenesis and hybrid linear quadrupole ion trap Fourier transform ion cyclotron resonance mass spectrometry

King, J. B., Gross, J., Lovly, C. M., Piwnica-Worms, H. & Townsend, R. R., 2007, In: Rapid Communications in Mass Spectrometry. 21, 21, p. 3443-3451 9 p.

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Nampt/PBEF/Visfatin Regulates Insulin Secretion in β Cells as a Systemic NAD Biosynthetic Enzyme

Revollo, J. R., Körner, A., Mills, K. F., Satoh, A., Wang, T., Garten, A., Dasgupta, B., Sasaki, Y., Wolberger, C., Townsend, R. R., Milbrandt, J., Kiess, W. & Imai, S. I., Nov 7 2007, In: Cell metabolism. 6, 5, p. 363-375 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

652 Scopus citations

Respiratory Uncoupling in Skeletal Muscle Delays Death and Diminishes Age-Related Disease

Gates, A. C., Bernal-Mizrachi, C., Chinault, S. L., Feng, C., Schneider, J. G., Coleman, T., Malone, J. P., Townsend, R. R., Chakravarthy, M. V. & Semenkovich, C. F., Dec 5 2007, In: Cell metabolism. 6, 6, p. 497-505 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

81 Scopus citations

The murine plasma protein response to polymicrobial intra-abdominal sepsis

McDunn, J. E., Townsend, R. R. & Cobb, J. P., Apr 1 2007, In: Proteomics - Clinical Applications. 1, 4, p. 373-386 14 p.

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Two Cys residues essential for von Willebrand factor multimer assembly in the Golgi

Purvis, A. R., Gross, J., Dang, L. T., Huang, R. H., Kapadia, M., Townsend, R. R. & Sadler, J. E., Oct 2 2007, In: Proceedings of the National Academy of Sciences of the United States of America. 104, 40, p. 15647-15652 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

53 Scopus citations

2006

Accurate mass-driven analysis for the characterization of protein phosphorylation. Study of the human Chk2 protein kinase

King, J. B., Gross, J., Lovly, C. M., Rohrs, H., Piwnica-Worms, H. & Townsend, R. R., Apr 1 2006, In: Analytical Chemistry. 78, 7, p. 2171-2181 11 p.

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Comparative proteomic analysis of two Entamoeba histolytica strains with different virulence phenotypes identifies peroxiredoxin as an important component of amoebic virulence

Davis, P. H., Zhang, X., Guo, J., Townsend, R. R. & Stanley, S. L., Sep 2006, In: Molecular Microbiology. 61, 6, p. 1523-1532 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

86 Scopus citations

Insulin protects islets from apoptosis via Pdx1 and specific changes in the human islet proteome

Johnson, J. D., Bernal-Mizrachi, E., Alejandro, E. U., Han, Z., Kalynyak, T. B., Li, H., Beith, J. L., Gross, J., Warnock, G. L., Townsend, R. R., Permutt, M. A. & Polonsky, K. S., Dec 19 2006, In: Proceedings of the National Academy of Sciences of the United States of America. 103, 51, p. 19575-19580 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

162 Scopus citations

R Reid Townsend

Research output

Search results