Qin Liu

2023

Dry eye disease in mice activates adaptive corneal epithelial regeneration distinct from constitutive renewal in homeostasis

Lin, J. B., Shen, X., Pfeifer, C. W., Shiau, F., Santeford, A., Ruzycki, P. A., Clark, B. S., Huang, A. J. W., Apte, R. S. & Liu, Q., Jan 10 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 2, e2204134120.

Research output: Contribution to journal › Article › peer-review

Open Access

2022

Estrogen metabolites increase nociceptor hyperactivity in a mouse model of uterine pain

Xie, Z., Feng, J., Cai, T., McCarthy, R., Eschbach, M. D., Wang, Y., Zhao, Y., Yi, Z., Zang, K., Yuan, Y., Hu, X., Li, F., Liu, Q., Das, A., England, S. K. & Hu, H., May 23 2022, In: JCI Insight. 7, 10, e149107.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Glutamate in primary afferents is required for itch transmission

Cui, L., Guo, J., Cranfill, S. L., Gautam, M., Bhattarai, J., Olson, W., Beattie, K., Challis, R. C., Wu, Q., Song, X., Raabe, T., Gradinaru, V., Ma, M., Liu, Q. & Luo, W., Mar 2 2022, In: Neuron. 110, 5, p. 809-823.e5

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

IL-33 signaling in sensory neurons promotes dry skin itch

Trier, A. M., Mack, M. R., Fredman, A., Tamari, M., Ver Heul, A. M., Zhao, Y., Guo, C. J., Avraham, O., Ford, Z. K., Oetjen, L. K., Feng, J., Dehner, C., Coble, D., Badic, A., Joshita, S., Kubo, M., Gereau, R. W., Alexander-Brett, J., Cavalli, V., Davidson, S., & 3 othersHu, H., Liu, Q. & Kim, B. S., Apr 2022, In: Journal of Allergy and Clinical Immunology. 149, 4, p. 1473-1480.e6

Research output: Contribution to journal › Article › peer-review

Open Access

25 Scopus citations

Miswiring of Merkel cell and pruriceptive C fiber drives the itch-scratch cycle

Feng, J., Zhao, Y., Xie, Z., Zang, K., Sviben, S., Hu, X., Fitzpatrick, J. A. J., Wen, L., Liu, Y., Wang, T., Lawson, K., Liu, Q., Yan, Y., Dong, X., Han, L., Wu, G. F., Kim, B. S. & Hu, H., Jul 13 2022, In: Science translational medicine. 14, 653, eabn4819.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

TRPC3 Antagonizes Pruritus in a Mouse Contact Dermatitis Model

Beattie, K., Jiang, H., Gautam, M., MacVittie, M. K., Miller, B., Ma, M., Liu, Q. & Luo, W., Apr 2022, In: Journal of Investigative Dermatology. 142, 4, p. 1136-1144 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

2021

A basophil-neuronal axis promotes itch

Wang, F., Trier, A. M., Li, F., Kim, S., Chen, Z., Chai, J. N., Mack, M. R., Morrison, S. A., Hamilton, J. D., Baek, J., Yang, T. L. B., Ver Heul, A. M., Xu, A. Z., Xie, Z., Dong, X., Kubo, M., Hu, H., Hsieh, C. S., Dong, X., Liu, Q., & 4 othersMargolis, D. J., Ardeleanu, M., Miller, M. J. & Kim, B. S., Jan 21 2021, In: Cell. 184, 2, p. 422-440.e17

Research output: Contribution to journal › Article › peer-review

Open Access

81 Scopus citations

Longitudinal intravital imaging nerve degeneration and sprouting in the toes of spared nerve injured mice

Yeh, H. Y., Lee, J. C., Chi, H. H., Chen, C. C., Liu, Q. & Yen, C. T., Aug 2021, In: Journal of Comparative Neurology. 529, 12, p. 3247-3264 18 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Sneezing reflex is mediated by a peptidergic pathway from nose to brainstem

Li, F., Jiang, H., Shen, X., Yang, W., Guo, C., Wang, Z., Xiao, M., Cui, L., Luo, W., Kim, B. S., Chen, Z., Huang, A. J. W. & Liu, Q., Jul 8 2021, In: Cell. 184, 14, p. 3762-3773.e10

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

2020

Kallikrein 7 Promotes Atopic Dermatitis-Associated Itch Independently of Skin Inflammation

Guo, C. J., Mack, M. R., Oetjen, L. K., Trier, A. M., Council, M. L., Pavel, A. B., Guttman-Yassky, E., Kim, B. S. & Liu, Q., Jun 2020, In: Journal of Investigative Dermatology. 140, 6, p. 1244-1252.e4

Research output: Contribution to journal › Article › peer-review

Open Access

25 Scopus citations

Quantitative Characterization of the Neuropeptide Level Changes in Dorsal Horn and Dorsal Root Ganglia Regions of the Murine Itch Models

Tillmaand, E. G., Anapindi, K. D. B., De La Toba, E. A., Guo, C. J., Krebs, J., Lenhart, A. E., Liu, Q. & Sweedler, J. V., Mar 6 2020, In: Journal of Proteome Research. 19, 3, p. 1248-1257 10 p.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

2019

Discovery of Benzamidine- And 1-Aminoisoquinoline-Based Human MAS-Related G-Protein-Coupled Receptor X1 (MRGPRX1) Agonists

Prchalová, E., Hin, N., Thomas, A. G., Veeravalli, V., Ng, J., Alt, J., Rais, R., Rojas, C., Li, Z., Hihara, H., Aoki, M., Yoshizawa, K., Nishioka, T., Suzuki, S., Kopajtic, T., Chatrath, S., Liu, Q., Dong, X., Slusher, B. S. & Tsukamoto, T., Sep 26 2019, In: Journal of Medicinal Chemistry. 62, 18, p. 8631-8641 11 p.

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Facilitation of MrgprD by TRP-A1 promotes neuropathic pain

Wang, C., Gu, L., Ruan, Y., Geng, X., Xu, M., Yang, N., Yu, L., Jiang, Y., Zhu, C., Yang, Y., Zhou, Y., Guan, X., Luo, W., Liu, Q., Dong, X., Yu, G., Lan, L. & Tang, Z., Jan 2019, In: FASEB Journal. 33, 1, p. 1360-1373 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

39 Scopus citations

TRESK K⁺ channel activity regulates trigeminal nociception and headache

Guo, Z., Qiu, C. S., Jiang, X., Zhang, J., Li, F., Liu, Q., Dhaka, A. & Cao, Y. Q., Jul 1 2019, In: eNeuro. 6, 4, ENEURO.0236-19.2019.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Scopus citations

TRPV1 activity and substance P release are required for corneal cold nociception

Li, F., Yang, W., Jiang, H., Guo, C., Huang, A. J. W., Hu, H. & Liu, Q., Dec 1 2019, In: Nature communications. 10, 1, 5678.

Research output: Contribution to journal › Article › peer-review

Open Access

42 Scopus citations

2018

Anatomical and functional dichotomy of ocular itch and pain

Huang, C. C., Yang, W., Guo, C., Jiang, H., Li, F., Xiao, M., Davidson, S., Yu, G., Duan, B., Huang, T., Huang, A. J. W. & Liu, Q., Aug 1 2018, In: Nature medicine. 24, 8, p. 1268-1276 9 p.

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Conopeptides promote itch through human itch receptor hMgprX1

Espino, S. S., Robinson, S. D., Safavi-Hemami, H., Gajewiak, J., Yang, W., Olivera, B. M. & Liu, Q., Nov 2018, In: Toxicon. 154, p. 28-34 7 p.

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Matrine inhibits itching by lowering the activity of calcium channel

Geng, X., Shi, H., Ye, F., Du, H., Qian, L., Gu, L., Wu, G., Zhu, C., Yang, Y., Wang, C., Zhou, Y., Yu, G., Liu, Q., Dong, X., Yu, L. & Tang, Z., Dec 1 2018, In: Scientific reports. 8, 1, 11328.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

Transient receptor potential vanilloid 4–expressing macrophages and keratinocytes contribute differentially to allergic and nonallergic chronic itch

Luo, J., Feng, J., Yu, G., Yang, P., Mack, M. R., Du, J., Yu, W., Qian, A., Zhang, Y., Liu, S., Yin, S., Xu, A., Cheng, J., Liu, Q., O'Neil, R. G., Xia, Y., Ma, L., Carlton, S. M., Kim, B. S., Renner, K., & 2 othersLiu, Q. & Hu, H., Feb 2018, In: Journal of Allergy and Clinical Immunology. 141, 2, p. 608-619.e7

Research output: Contribution to journal › Article › peer-review

Open Access

58 Scopus citations

2017

A novel TRPM8 agonist relieves dry eye discomfort

Yang, J. M., Li, F., Liu, Q., Rüedi, M., Wei, E. T., Lentsman, M., Lee, H. S., Choi, W., Kim, S. J. & Yoon, K. C., Jun 26 2017, In: BMC Ophthalmology. 17, 1, 101.

Research output: Contribution to journal › Article › peer-review

Open Access

25 Scopus citations

Leaky Gate Model: Intensity-Dependent Coding of Pain and Itch in the Spinal Cord

Sun, S., Xu, Q., Guo, C., Guan, Y., Liu, Q. & Dong, X., Feb 22 2017, In: Neuron. 93, 4, p. 840-853.e5

Research output: Contribution to journal › Article › peer-review

Open Access

88 Scopus citations

Sensory Neurons Co-opt Classical Immune Signaling Pathways to Mediate Chronic Itch

Oetjen, L. K., Mack, M. R., Feng, J., Whelan, T. M., Niu, H., Guo, C. J., Chen, S., Trier, A. M., Xu, A. Z., Tripathi, S. V., Luo, J., Gao, X., Yang, L., Hamilton, S. L., Wang, P. L., Brestoff, J. R., Council, M. L., Brasington, R., Schaffer, A., Brombacher, F., & 8 othersHsieh, C. S., Gereau, R. W., Miller, M. J., Chen, Z. F., Hu, H., Davidson, S., Liu, Q. & Kim, B. S., Sep 21 2017, In: Cell. 171, 1, p. 217-228.e13

Research output: Contribution to journal › Article › peer-review

Open Access

492 Scopus citations

TRPC3 Is Dispensable for β-Alanine Triggered Acute Itch

Dong, P., Guo, C., Huang, S., Ma, M., Liu, Q. & Luo, W., Dec 1 2017, In: Scientific reports. 7, 1, 13869.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

2016

A histamine-independent itch pathway is required for allergic ocular itch

Huang, C. C., Kim, Y. S., Olson, W. P., Li, F., Guo, C., Luo, W., Huang, A. J. W. & Liu, Q., Apr 1 2016, In: Journal of Allergy and Clinical Immunology. 137, 4, p. 1267-1270.e6

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Enhanced itch elicited by capsaicin in a chronic itch model

Yu, G., Yang, N., Li, F., Chen, M., Guo, C. J., Wang, C., Hu, D., Yang, Y., Zhu, C., Wang, Z., Shi, H., Gegen, T., Tang, M., He, Q., Liu, Q. & Tang, Z., Apr 23 2016, In: Molecular Pain. 12

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

Voltage-gated potassium channels involved in regulation of physiological function in MrgprA3-specific itch neurons

Tang, M., Wu, G., Wang, Z., Yang, N., Shi, H., He, Q., Zhu, C., Yang, Y., Yu, G., Wang, C., Yuan, X., Liu, Q., Guan, Y., Dong, X. & Tang, Z., Apr 1 2016, In: Brain Research. 1636, p. 161-171 11 p.

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

2015

Pirt contributes to uterine contraction-induced pain in mice

Wang, C., Wang, Z., Yang, Y., Zhu, C., Wu, G., Yu, G., Jian, T., Yang, N., Shi, H., Tang, M., He, Q., Lan, L., Liu, Q., Guan, Y., Dong, X., Duan, J. & Tang, Z., Sep 17 2015, In: Molecular Pain. 11, 1, 57.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

The role of the mrgpr receptor family in Itch

Liu, Q., Liu, Q., Liu, Q., Dong, X. & Dong, X., 2015, In: Handbook of Experimental Pharmacology. 226, p. 71-88 18 p.

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Transient receptor potential A1 activation prolongs isoflurane induction latency and impairs respiratory function in mice

Li, F., Guo, C. J., Huang, C. C., Yu, G., Brown, S. M., Xu, S. & Liu, Q., Apr 20 2015, In: Anesthesiology. 122, 4, p. 768-775 8 p.

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

2014

Activation of MrgC receptor inhibits N-type calcium channels in small-diameter primary sensory neurons in mice

Li, Z., He, S. Q., Xu, Q., Yang, F., Tiwari, V., Liu, Q., Tang, Z., Han, L., Chu, Y. X., Wang, Y., Hin, N., Tsukamoto, T., Slusher, B., Guan, X., Wei, F., Raja, S. N., Dong, X. & Guan, Y., Aug 2014, In: Pain. 155, 8, p. 1613-1621 9 p.

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Balloon aortic valvuloplasty as a bridge to liver transplantation in patients with severe aortic stenosis: A case series

Kalarickal, P., Liu, Q., Rathor, R., Ishag, S., Kerr, T. & Kangrga, I., 2014, In: Transplantation Proceedings. 46, 10, p. 3492-3495 4 p.

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

MrgC agonism at central terminals of primary sensory neurons inhibits neuropathic pain

He, S. Q., Li, Z., Chu, Y. X., Han, L., Xu, Q., Li, M., Yang, F., Liu, Q., Tang, Z., Wang, Y., Hin, N., Tsukamoto, T., Slusher, B., Tiwari, V., Shechter, R., Wei, F., Raja, S. N., Dong, X. & Guan, Y., Mar 2014, In: Pain. 155, 3, p. 534-544 11 p.

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Peptidomimetics of Arg-Phe-NH₂ as small molecule agonists of Mas-related gene C (MrgC) receptors

Hin, N., Alt, J., Zimmermann, S. C., Delahanty, G., Ferraris, D. V., Rojas, C., Li, F., Liu, Q., Dong, X., Slusher, B. S. & Tsukamoto, T., Nov 1 2014, In: Bioorganic and Medicinal Chemistry. 22, 21, p. 5831-5837 7 p.

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

2013

A subpopulation of nociceptors specifically linked to itch

Han, L., Ma, C., Liu, Q., Weng, H. J., Cui, Y., Tang, Z., Kim, Y., Nie, H., Qu, L., Patel, K. N., Li, Z., McNeil, B., He, S., Guan, Y., Xiao, B., Lamotte, R. H. & Dong, X., Feb 2013, In: Nature neuroscience. 16, 2, p. 174-182 9 p.

Research output: Contribution to journal › Article › peer-review

278 Scopus citations

2012

Mechanisms of itch evoked by β-alanine

Liu, Q., Sikand, P., Ma, C., Tang, Z., Han, L., Li, Z., Sun, S., LaMotte, R. H. & Dong, X., Oct 17 2012, In: Journal of Neuroscience. 32, 42, p. 14532-14537 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

212 Scopus citations

TLR3 deficiency impairs spinal cord synaptic transmission, central sensitization, and pruritus in mice

Liu, T., Berta, T., Xu, Z. Z., Park, C. K., Zhang, L., Lü, N., Liu, Q., Liu, Y., Gao, Y. J., Liu, Y. C., Ma, Q., Dong, X. & Ji, R. R., Jun 1 2012, In: Journal of Clinical Investigation. 122, 6, p. 2195-2207 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

128 Scopus citations

2011

Pirt, a TRPV1 modulator, is required for histamine-dependent and -independent itch

Patel, K. N., Liu, Q., Meeker, S., Undem, B. J. & Dong, X., 2011, In: PloS one. 6, 5, e20559.

Research output: Contribution to journal › Article › peer-review

Open Access

33 Scopus citations

The distinct roles of two GPCRs, MrgprC11 and PAR2, in itch and hyperalgesia

Liu, Q., Weng, H. J., Patel, K. N., Tang, Z., Bai, H., Steinhoff, M. & Dong, X., Jul 12 2011, In: Science signaling. 4, 181, ra45.

Research output: Contribution to journal › Article › peer-review

109 Scopus citations

TRPA1 is required for histamine-independent, Mas-related G protein-coupled receptor-mediated itch

Wilson, S. R., Gerhold, K. A., Bifolck-Fisher, A., Liu, Q., Patel, K. N., Dong, X. & Bautista, D. M., May 2011, In: Nature neuroscience. 14, 5, p. 595-603 9 p.

Research output: Contribution to journal › Article › peer-review

442 Scopus citations

2010

Mas-related G-protein-coupled receptors inhibit pathological pain in mice

Guan, Y., Liu, Q., Tang, Z., Raja, S. N., Anderson, D. J. & Dong, X., Sep 7 2010, In: Proceedings of the National Academy of Sciences of the United States of America. 107, 36, p. 15933-15938 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

64 Scopus citations

2009

Sensory Neuron-Specific GPCR Mrgprs Are Itch Receptors Mediating Chloroquine-Induced Pruritus

Liu, Q., Tang, Z., Surdenikova, L., Kim, S., Patel, K. N., Kim, A., Ru, F., Guan, Y., Weng, H. J., Geng, Y., Undem, B. J., Kollarik, M., Chen, Z. F., Anderson, D. J. & Dong, X., Dec 24 2009, In: Cell. 139, 7, p. 1353-1365 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

577 Scopus citations

2008

Agonists of the Mas-related gene (Mrgs) orphan receptors as novel mediators of mast cell-sensory nerve interactions

Lee, M. G., Dong, X., Liu, Q., Patel, K. N., Choi, O. H., Vonakis, B. & Undem, B. J., Feb 15 2008, In: Journal of Immunology. 180, 4, p. 2251-2255 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

35 Scopus citations

Pirt, a Phosphoinositide-Binding Protein, Functions as a Regulatory Subunit of TRPV1

Kim, A. Y., Tang, Z., Liu, Q., Patel, K. N., Maag, D., Geng, Y. & Dong, X., May 2 2008, In: Cell. 133, 3, p. 475-485 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

155 Scopus citations

2007

Molecular genetic visualization of a rare subset of unmyelinated sensory neurons that may detect gentle touch

Liu, Q., Vrontou, S., Rice, F. L., Zylka, M. J., Dong, X. & Anderson, D. J., Aug 2007, In: Nature neuroscience. 10, 8, p. 946-948 3 p.

Research output: Contribution to journal › Article › peer-review

155 Scopus citations

Qin Liu

Research output

Search results