• 2863 Citations
1984 …2020

Research output per year

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Personal profile

Research interests

My laboratory is interested in understanding the biology of nuclear hormone receptors in the heart. In particular, we have focused on the PPAR (Peroxisome Proliferator-Activated Receptor) family of transcription factors as well as PPAR-interacting proteins and their respective roles in molecular regulatory pathways that control cardiac energy metabolism and mitochondrial function in health and disease. As the heart relies primarily on fatty acids as the choice of substrate for ATP production, we have generally focused on mechanisms that control lipid handling and oxidation. The activity of the PPAR transcriptional complex and the capacity of the heart to normally oxidize fatty acids is altered in all forms of cardiac disease, including hypertrophy, dilated cardiomyopathy, ischemia, diabetes, and aging. The laboratory employs a wide variety of molecular, cellular, and animal models to further our research goals of understanding the molecular mechanisms of PPAR regulation in cardiac disease. To this end, we have most recently focused on understanding the biology of PPAR Binding Protein (PBP/MED), a molecule that integrates signals through several transcriptional pathways to maintain normal mitochondrial number and function.

Areas of Clinical Interest

Congenital heart disease in adults

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Research Output

  • 2863 Citations
  • 31 Article
  • 7 Review article
  • 1 Editorial

Ten-year outcomes in adult patients with congenital heart disease and implantable cardioverter-defibrillators

Brouillard, A. M., Al-Hammadi, N., Hunt, C., Barger, P., Ludbrook, P. & Gleva, M. J., Jan 1 2020, (Accepted/In press) In : International Journal of Cardiology.

Research output: Contribution to journalArticle

  • Immunomodulatory role of nonneuronal cholinergic signaling in myocardial injury

    Rocha-Resende, C., Weinheimer, C., Bajpai, G., Adamo, L., Matkovich, S. J., Schilling, J., Barger, P. M., Lavine, K. J. & Mann, D. L., Jul 25 2019, In : JCI Insight. 4, 14, e128961.

    Research output: Contribution to journalArticle

    Open Access
  • 4 Scopus citations
  • 1 Scopus citations

    Impact of pregnancy on autograft dilatation and aortic valve function following the Ross procedure

    Carvajal, H. G., Lindley, K. J., Shah, T., Brar, A. K., Barger, P. M., Billadello, J. J. & Eghtesady, P., Mar 1 2018, In : Congenital Heart Disease. 13, 2, p. 217-221 5 p.

    Research output: Contribution to journalArticle

  • 10 Scopus citations