Personal profile
Research interests
Our laboratory is studying DNA replication and DNA damage response mechanisms in the yeast Saccharomyces cerevisiae and in human cells. Yeast is an ideal eukaryotic organism to study these pathways, both at a genetic and at a biochemical level. It is important to understand these mechanisms in yeast because defects in the highly analogous pathways in humans are known to result in damage susceptibility and show a predisposition to various forms of cancer.
Available to Mentor:
- PhD Students
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Collaborations and top research areas from the last five years
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DNA Damage and Replication Stress Checkpoints
Yates, L. A., Zhang, X. & Burgers, P. M., Jun 20 2025, In: Annual review of biochemistry. 94, 1, p. 195-221 27 p.Research output: Contribution to journal › Review article › peer-review
Open Access9 Link opens in a new tab Scopus citations -
DNA polymerase zeta can efficiently replicate structures formed by AT/TA repeat sequences and prevent their deletion
Das, M., Hile, S. E., Brewster, J., Boer, J. L., Bezalel-Buch, R., Guo, Q., Yang, W., Burgers, P. M., Eckert, K. A. & Freudenreich, C. H., Feb 10 2025, In: Nucleic acids research. 53, 3, gkae1254.Research output: Contribution to journal › Article › peer-review
Open Access3 Link opens in a new tab Scopus citations -
A DNA damage–induced phosphorylation circuit enhances Mec1ATR Ddc2ATRIP recruitment to Replication Protein A
Yates, L. A., Tannous, E. A., Morgan, R. M., Burgers, P. M. & Zhang, X., 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 14, e2300150120.Research output: Contribution to journal › Article › peer-review
Open Access8 Link opens in a new tab Scopus citations -
Mechanism of auto-inhibition and activation of Mec1ATR checkpoint kinase
Tannous, E. A., Yates, L. A., Zhang, X. & Burgers, P. M., Jan 2021, In: Nature Structural and Molecular Biology. 28, 1, p. 50-61 12 p.Research output: Contribution to journal › Article › peer-review
Open Access27 Link opens in a new tab Scopus citations -
Novel insights into the mechanism of cell cycle kinases Mec1(ATR) and Tel1(ATM)
Tannous, E. A. & Burgers, P. M., 2021, In: Critical Reviews in Biochemistry and Molecular Biology. 56, 5, p. 441-454 14 p.Research output: Contribution to journal › Review article › peer-review
Open Access9 Link opens in a new tab Scopus citations