Research output per year
Research output per year
Personal profile
Research interests
Our laboratory is studying DNA replication and DNA damage response mechanisms in the yeast Saccharomyces cerevisiae and in human cells. Yeast is an ideal eukaryotic organism to study these pathways, both at a genetic and at a biochemical level. It is important to understand these mechanisms in yeast because defects in the highly analogous pathways in humans are known to result in damage susceptibility and show a predisposition to various forms of cancer.
Available to Mentor:
- PhD/MSTP Students
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Collaborations and top research areas from the last five years
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A DNA damage–induced phosphorylation circuit enhances Mec1ATR Ddc2ATRIP recruitment to Replication Protein A
Yates, L. A., Tannous, E. A., Morgan, R. M., Burgers, P. M. & Zhang, X., 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 14, e2300150120.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Mechanism of auto-inhibition and activation of Mec1ATR checkpoint kinase
Tannous, E. A., Yates, L. A., Zhang, X. & Burgers, P. M., Jan 2021, In: Nature Structural and Molecular Biology. 28, 1, p. 50-61 12 p.Research output: Contribution to journal › Article › peer-review
Open Access16 Scopus citations -
Novel insights into the mechanism of cell cycle kinases Mec1(ATR) and Tel1(ATM)
Tannous, E. A. & Burgers, P. M., 2021, In: Critical Reviews in Biochemistry and Molecular Biology. 56, 5, p. 441-454 14 p.Research output: Contribution to journal › Review article › peer-review
Open Access5 Scopus citations -
The fidelity of DNA replication, particularly on GC-rich templates, is reduced by defects of the Fe-S cluster in DNA polymerase δ
Kiktev, D. A., Dominska, M., Zhang, T., Dahl, J., Stepchenkova, E. I., Mieczkowski, P., Burgers, P. M., Lujan, S., Burkholder, A., Kunkel, T. A. & Petes, T. D., Jun 4 2021, In: Nucleic acids research. 49, 10, p. 5623-5636 14 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Bypass of DNA interstrand crosslinks by a Rev1-DNA polymerase ζ complex
Bezalel-Buch, R., Cheun, Y. K., Roy, U., Schärer, O. D. & Burgers, P. M., Sep 4 2020, In: Nucleic acids research. 48, 15, p. 8461-8473 13 p.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations