Peng Yuan

Assistant Professor of Cell Biology and Physiology

    • 620 Citations
    20082020

    Research output per year

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    Personal profile

    Research interests

    Our laboratory is interested in understanding the molecular mechanisms of ion channels and transporters that play essential roles in human physiology and disease. How do channels and transporters recognize their specific substrate ions? How do they respond to various stimuli including chemical ligand, temperature, membrane voltage, and mechanical force? How do they interact with the lipid membrane where they reside? To answer these fundamental questions, we use multidisciplinary approaches including X-ray crystallography, biochemistry, biophysics, and electrophysiology. Dysfunction of these membrane proteins could lead to a variety of diseases such as asthma, hypertension, cancer, heart failure, diabetes, chronic pain, and many more. Our long-term goal is to provide detailed mechanistic understanding of ion channels and transporters, which will offer novel strategies for drug development and better treatment of diseases.

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    Research Output

    • 620 Citations
    • 15 Article
    • 1 Letter
    • 1 Review article

    Atomistic basis of opening and conduction in mammalian inward rectifier potassium (Kir2.2) channels

    Zangerl-Plessl, E. M., Lee, S. J., Maksaev, G., Bernsteiner, H., Ren, F., Yuan, P., Stary-Weinzinger, A. & Nichols, C. G., Jan 6 2020, In : The Journal of general physiology. 152, 1

    Research output: Contribution to journalArticle

    Open Access
  • 2 Scopus citations

    Coupling of Ca2+and voltage activation in BK channels through the aB helix/voltage sensor interface

    Geng, Y., Deng, Z., Zhang, G., Budelli, G., Butler, A., Yuan, P., Cui, J., Salkoff, L., Salkoff, L. & Magleby, K. L., Jun 23 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 25, p. 14512-14521 10 p.

    Research output: Contribution to journalArticle

  • Cryo-EM structures of the ATP release channel pannexin 1

    Deng, Z., He, Z., Maksaev, G., Bitter, R. M., Rau, M., Fitzpatrick, J. A. J. & Yuan, P., Apr 1 2020, In : Nature Structural and Molecular Biology. 27, 4, p. 373-381 9 p.

    Research output: Contribution to journalArticle

  • 4 Scopus citations

    Gating of human TRPV3 in a lipid bilayer

    Deng, Z., Maksaev, G., Rau, M., Xie, Z., Hu, H., Fitzpatrick, J. A. J. & Yuan, P., Jul 1 2020, In : Nature Structural and Molecular Biology. 27, 7, p. 635-644 10 p.

    Research output: Contribution to journalArticle

  • Structural mechanism for gating of a eukaryotic mechanosensitive channel of small conductance

    Deng, Z., Maksaev, G., Schlegel, A. M., Zhang, J., Rau, M., Fitzpatrick, J. A. J., Haswell, E. S. & Yuan, P., Dec 1 2020, In : Nature communications. 11, 1, 3690.

    Research output: Contribution to journalArticle

    Open Access
  • 1 Scopus citations