Paul Schlesinger

Associate Professor of Cell Biology and Physiology

    • 11116 Citations
    1973 …2020

    Research output per year

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    Personal profile

    Research interests

    My research has focused on intracellular transport of ions, including protons, their influence on the physiology of cells. Over the years this has included the acidification of intracellular vesicles, chloroquine transport and resistant malaria parasites, intracellular mycobacteria, bone resorption, intracellular chloride channels, membrane channels and pores formed by Bcl-2 family proteins in apoptosis and the synthesis and characterization of synthetic channels. Currently we are actively studying the ion transport of bone resorption with a major emphasis on the expression of the proton pump and it regulation via intracellular chloride channels. In a second project we are characterizing the pore formation and cytchrome c transport by Bcl-2 family proteins in liposomes and mitochondria. They are primarily biophysical and biochemical studies on the mechanism of pore formation by these membrane proteins and in particular on the activiation of Bax the major proapoptotic regulator. The last project I will describe is the synthesis and characterization of synthetic ion channels. We are using this as a way to study and understand the chemical factors which contribute to ion channel transport through membranes. As we have developed these compounds, they are being applied to the study of cellular ion homeostasis and as reagents against bacteria and cells. In addressing these questions, my laboratory has applied numerous techniques ranging from cell and molecular biology, biophysical chemistry, molecular modeling and electrophysiology.

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    Research Output

    Cellular and extracellular matrix of bone, with principles of synthesis and dependency of mineral deposition on cell membrane transport

    Schlesinger, P. H., Blair, H. C., Stolz, D. B., Riazanski, V., Ray, E. C., Tourkova, I. L. & Nelson, D. J., Jan 1 2020, In : American Journal of Physiology - Cell Physiology. 318, 1, p. C111-C124

    Research output: Contribution to journalReview article

  • 1 Scopus citations

    Phylogeny and chemistry of biological mineral transport

    Schlesinger, P. H., Braddock, D. T., Larrouture, Q. C., Ray, E. C., Riazanski, V., Nelson, D. J., Tourkova, I. L. & Blair, H. C., 2020, (Accepted/In press) In : Bone. 115621.

    Research output: Contribution to journalReview article

  • Anti-JNK2 peptide–siRNA nanostructures improve plaque endothelium and reduce thrombotic risk in atherosclerotic mice

    Pan, H., Palekar, R. U., Hou, K. K., Bacon, J., Yan, H., Springer, L. E., Akk, A., Yang, L., Miller, M. J., Pham, C. T. N., Schlesinger, P. H. & Wickline, S. A., Jan 1 2018, In : International Journal of Nanomedicine. 13, p. 5187-5205 19 p.

    Research output: Contribution to journalArticle

    Open Access
  • 5 Scopus citations

    Design, synthesis, and biological evaluation of stable β6.3-Helices: Discovery of non-hemolytic antibacterial peptides

    Reddy, D. N., Singh, S., Ho, C. M. W., Patel, J., Schlesinger, P., Rodgers, S., Doctor, A. & Marshall, G. R., Apr 10 2018, In : European Journal of Medicinal Chemistry. 149, p. 193-210 18 p.

    Research output: Contribution to journalArticle

  • 2 Scopus citations

    Mechanism of high-level daptomycin resistance in Corynebacterium striatum

    Goldner, N. K., Bulow, C., Cho, K., Wallace, M., Hsu, F. F., Patti, G. J., Burnham, C. A., Schlesinger, P. & Dantasa, G., Jul 1 2018, In : mSphere. 3, 4, 37118.

    Research output: Contribution to journalArticle

    Open Access
  • 8 Scopus citations