Paul Kotzbauer

Article

Aggregated alpha-synuclein transcriptionally activates pro-inflammatory canonical and non-canonical NF-κB signaling pathways in peripheral monocytic cells

Bearoff, F., Dhavale, D., Kotzbauer, P. & Kortagere, S., Feb 2023, In: Molecular Immunology. 154, p. 1-10 10 p.

Research output: Contribution to journal › Article › peer-review

Alpha Synuclein Fibrils Contain Multiple Binding Sites for Small Molecules

Hsieh, C. J., Ferrie, J. J., Xu, K., Lee, I., Graham, T. J. A., Tu, Z., Yu, J., Dhavale, D., Kotzbauer, P., Petersson, E. J. & Mach, R. H., Nov 21 2018, In: ACS Chemical Neuroscience. 9, 11, p. 2521-2527 7 p.

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Altered neuronal mitochondrial coenzyme A synthesis in neurodegeneration with brain iron accumulation caused by abnormal processing, stability, and catalytic activity of mutant pantothenate kinase 2

Kotzbauer, P. T., Truax, A. C., Trojanowski, J. Q. & Lee, V. M. Y., Jan 19 2005, In: Journal of Neuroscience. 25, 3, p. 689-698 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

119 Scopus citations

APOE genotype regulates pathology and disease progression in synucleinopathy

Davis, A. A., Inman, C. E., Wargel, Z. M., Dube, U., Freeberg, B. M., Galluppi, A., Haines, J. N., Dhavale, D. D., Miller, R., Choudhury, F. A., Sullivan, P. M., Cruchaga, C., Perlmutter, J. S., Ulrich, J. D., Benitez, B. A., Kotzbauer, P. T. & Holtzman, D. M., Feb 5 2020, In: Science translational medicine. 12, 529, eaay3069.

Research output: Contribution to journal › Article › peer-review

67 Scopus citations

A quantitative study of α-synuclein pathology in fifteen cases of dementia associated with Parkinson disease

Armstrong, R. A., Kotzbauer, P. T., Perlmutter, J. S., Campbell, M. C., Hurth, K. M., Schmidt, R. E. & Cairns, N. J., Feb 2014, In: Journal of Neural Transmission. 121, 2, p. 171-181 11 p.

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

A sensitive assay reveals structural requirements for α-synuclein fibril growth

Dhavale, D. D., Tsai, C., Bagchi, D. P., Engel, L. A., Sarezky, J. & Kotzbauer, P. T., Jun 2 2017, In: Journal of Biological Chemistry. 292, 22, p. 9034-9050 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

Binding of the Radioligand SIL23 to α-Synuclein Fibrils in Parkinson Disease Brain Tissue Establishes Feasibility and Screening Approaches for Developing a Parkinson Disease Imaging Agent

Bagchi, D. P., Yu, L., Perlmutter, J. S., Xu, J., Mach, R. H., Tu, Z. & Kotzbauer, P. T., Feb 6 2013, In: PloS one. 8, 2, e55031.

Research output: Contribution to journal › Article › peer-review

Open Access

82 Scopus citations

Catalytic function of PLA2G6 is impaired by mutations associated with infantile neuroaxonal dystrophy but not dystonia-parkinsonism

Engel, L. A., Jing, Z., O'Brien, D. E., Sun, M. & Kotzbauer, P. T., 2010, In: PloS one. 5, 9, e12897.

Research output: Contribution to journal › Article › peer-review

Open Access

83 Scopus citations

Chalcones and Five-Membered Heterocyclic Isosteres Bind to Alpha Synuclein Fibrils in Vitro

Hsieh, C. J., Xu, K., Lee, I., Graham, T. J. A., Tu, Z., Dhavale, D., Kotzbauer, P. & Mach, R. H., Apr 30 2018, In: ACS Omega. 3, 4, p. 4486-4493 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

23 Scopus citations

Correlation between decreased CSF α-synuclein and Aβ_1-42 in Parkinson disease

Buddhala, C., Campbell, M. C., Perlmutter, J. S. & Kotzbauer, P. T., Jan 1 2015, In: Neurobiology of Aging. 36, 1, p. 476-484 9 p.

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

CSF proteins and resting-state functional connectivity in Parkinson disease

Campbell, M. C., Koller, J. M., Snyder, A. Z., Buddhala, C., Kotzbauer, P. T. & Perlmutter, J. S., Jun 16 2015, In: Neurology. 84, 24, p. 2413-2421 9 p.

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Cytosolic phospholipase A₂ plays a crucial role in ROS/NO signaling during microglial activation through the lipoxygenase pathway

Chuang, D. Y., Simonyi, A., Kotzbauer, P. T., Gu, Z. & Sun, G. Y., Oct 31 2015, In: Journal of Neuroinflammation. 12, 1, 199.

Research output: Contribution to journal › Article › peer-review

Open Access

70 Scopus citations

Design, Synthesis, and Characterization of 3-(Benzylidene)indolin-2-one Derivatives as Ligands for α-Synuclein Fibrils

Chu, W., Zhou, D., Gaba, V., Liu, J., Li, S., Peng, X., Xu, J., Dhavale, D., Bagchi, D. P., D'Avignon, A., Shakerdge, N. B., Bacskai, B. J., Tu, Z., Kotzbauer, P. T. & Mach, R. H., Jul 15 2015, In: Journal of Medicinal Chemistry. 58, 15, p. 6002-6017 16 p.

Research output: Contribution to journal › Article › peer-review

75 Scopus citations

Design, synthesis, and in vitro evaluation of quinolinyl analogues for α-synuclein aggregation

Yue, X., Dhavale, D. D., Li, J., Luo, Z., Liu, J., Yang, H., Mach, R. H., Kotzbauer, P. T. & Tu, Z., Apr 1 2018, In: Bioorganic and Medicinal Chemistry Letters. 28, 6, p. 1011-1019 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

Detection of TAR DNA-binding protein 43 (TDP-43) oligomers as initial intermediate species during aggregate formation

French, R. L., Grese, Z. R., Aligireddy, H., Dhavale, D. D., Reeb, A. N., Kedia, N., Kotzbauer, P. T., Bieschke, J. & Ayala, Y. M., Apr 26 2019, In: Journal of Biological Chemistry. 294, 17, p. 6696-6709 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

55 Scopus citations

Developmentally-regulated lectin binding in the embryonic mouse telencephalon

Flaris, N. A., Shindler, K. S., Kotzbauer, P. T., Chand, P., Ludwig, C. P., Konstantinidou, A. D. & Roth, K. A., Apr 24 1995, In: Brain Research. 678, 1-2, p. 99-109 11 p.

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Disrupted membrane homeostasis and accumulation of ubiquitinated proteins in a mouse model of infantile neuroaxonal dystrophy caused by PLA2G6 mutations

Malik, I., Turk, J., Mancuso, D. J., Montier, L., Wohltmann, M., Wozniak, D. F., Schmidt, R. E., Gross, R. W. & Kotzbauer, P. T., Feb 2008, In: American Journal of Pathology. 172, 2, p. 406-416 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

127 Scopus citations

Dopaminergic, serotonergic, and noradrenergic deficits in Parkinson disease

Buddhala, C., Loftin, S. K., Kuley, B. M., Cairns, N. J., Campbell, M. C., Perlmutter, J. S. & Kotzbauer, P. T., Oct 2015, In: Annals of Clinical and Translational Neurology. 2, 10, p. 949-959 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

118 Scopus citations

Expression of neurturin, GDNF, and their receptors in the adult mouse CNS

Golden, J. P., Baloh, R. H., Kotzbauer, P. T., Lampe, P. A., Osborne, P. A., Milbrandt, J. & Johnson, E. M., Aug 17 1998, In: Journal of Comparative Neurology. 398, 1, p. 139-150 12 p.

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Fibrillization of α-synuclein and tau in familial Parkinson's disease caused by the A53T α-synuclein mutation

Kotzbauer, P. T., Giasson, B. I., Kravitz, A. V., Golbe, L. I., Mark, M. H., Trojanowski, J. Q. & Lee, V. M. Y., Jun 2004, In: Experimental Neurology. 187, 2, p. 279-288 10 p.

Research output: Contribution to journal › Article › peer-review

137 Scopus citations

Fluselenamyl: A novel benzoselenazole derivative for pet detection of amyloid plaques (Aβ) in Alzheimer's disease

Sundaram, G. S. M., Dhavale, D. D., Prior, J. L., Yan, P., Cirrito, J., Rath, N. P., Laforest, R., Cairns, N. J., Lee, J. M., Kotzbauer, P. T. & Sharma, V., Nov 2 2016, In: Scientific reports. 6, 35636.

Research output: Contribution to journal › Article › peer-review

Open Access

30 Scopus citations

Functional genomic analyses uncover APOE-mediated regulation of brain and cerebrospinal fluid beta-amyloid levels in Parkinson disease

Ibanez, L., Bahena, J. A., Yang, C., Dube, U., Farias, F. H. G., Budde, J. P., Bergmann, K., Brenner-Webster, C., Morris, J. C., Perrin, R. J., Cairns, N. J., O’Donnell, J., Álvarez, I., Diez-Fairen, M., Aguilar, M., Miller, R., Davis, A. A., Pastor, P., Kotzbauer, P., Campbell, M. C., & 5 othersPerlmutter, J. S., Rhinn, H., Harari, O., Cruchaga, C. & Benitez, B. A., Dec 2020, In: Acta Neuropathologica Communications. 8, 1, 196.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

Genetic ablation of calcium-independent phospholipase A₂γ leads to alterations in hippocampal cardiolipin content and molecular species distribution, mitochondrial degeneration, autophagy, and cognitive dysfunction

Mancuso, D. J., Kotzbauer, P., Wozniak, D. F., Sims, H. F., Jenkins, C. M., Guan, S., Han, X., Yang, K., Sun, G., Malik, I., Conyers, S., Green, K. G., Schmidt, R. E. & Gross, R. W., Dec 18 2009, In: Journal of Biological Chemistry. 284, 51, p. 35632-35644 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

79 Scopus citations

Hemin-induced transcriptional activation of the HSP70 gene during erythroid maturation in K562 cells is due to a heat shock factor-mediated stress response

Theodorakis, N. G., Zand, D. J., Kotzbauer, P. T., Williams, G. T. & Morimoto, R. I., 1989, In: Molecular and cellular biology. 9, 8, p. 3166-3173 8 p.

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds

Holmes, B. B., DeVos, S. L., Kfoury, N., Li, M., Jacks, R., Yanamandra, K., Ouidja, M. O., Brodsky, F. M., Marasa, J., Bagchi, D. P., Kotzbauer, P. T., Miller, T. M., Papy-Garcia, D. & Diamond, M. I., Aug 13 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 33, p. E3138-E3147

Research output: Contribution to journal › Article › peer-review

Open Access

564 Scopus citations

Increased risk of parkinsonism associated with welding exposure

Racette, B. A., Criswell, S. R., Lundin, J. I., Hobson, A., Seixas, N., Kotzbauer, P. T., Evanoff, B. A., Perlmutter, J. S., Zhang, J., Sheppard, L. & Checkoway, H., Oct 2012, In: NeuroToxicology. 33, 5, p. 1356-1361 6 p.

Research output: Contribution to journal › Article › peer-review

108 Scopus citations

Initiation and synergistic fibrillization of tau and alpha-synuctein

Giasson, B. I., Forman, M. S., Higuchi, M., Golbe, L. I., Graves, C. L., Kotzbauer, P. T., Trojanowski, J. Q. & Lee, V. M. Y., Apr 25 2003, In: Science. 300, 5619, p. 636-640 5 p.

Research output: Contribution to journal › Article › peer-review

712 Scopus citations

In vitro activation of heat shock transcription factor DNA-binding by calcium and biochemical conditions that affect protein conformation

Mosser, D. D., Kotzbauer, P. T., Sarge, K. D. & Morimoto, R. I., 1990, In: Proceedings of the National Academy of Sciences of the United States of America. 87, 10, p. 3748-3752 5 p.

Research output: Contribution to journal › Article › peer-review

237 Scopus citations

Is Levodopa Response a Valid Indicator of Parkinson's Disease?

Martin, W. R. W., Miles, M., Zhong, Q., Hartlein, J., Racette, B. A., Norris, S. A., Ushe, M., Maiti, B., Criswell, S., Davis, A. A., Kotzbauer, P. T., Cairns, N. J., Perrin, R. J. & Perlmutter, J. S., Apr 2021, In: Movement Disorders. 36, 4, p. 948-954 7 p.

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Lewy body pathology in Alzheimer's disease

Kotzbauer, P. T., Trojanowski, J. Q. & Lee, V. M. Y., Jan 1 2001, In: Journal of Molecular Neuroscience. 17, 2, p. 225-232 8 p.

Research output: Contribution to journal › Article › peer-review

128 Scopus citations

Midkine induces tumor cell proliferation and binds to a high affinity signaling receptor associated with JAK tyrosine kinases

Ratovitski, E. A., Kotzbauer, P. T., Milbrandt, J., Lowenstein, C. J. & Burrow, C. R., Feb 6 1998, In: Journal of Biological Chemistry. 273, 6, p. 3654-3660 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

Neocortical Lewy Body Pathology Parallels Parkinson's Dementia, but Not Always

Martin, W. R. W., Younce, J., Campbell, M., Racette, B., Norris, S., Ushe, M., Criswell, S., Davis, G., Alfradique-Dunham, I., Maiti, B., Cairns, N. J., Perrin, R. J., Kotzbauer, P. T. & Perlmutter, J. S., Jan 2023, In: Annals of neurology. 93, 1, p. 184-195 12 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Neurodegeneration associated with genetic defects in phospholipase A2

Gregory, A., Westaway, S. K., Holm, I. E., Kotzbauer, P. T., Hogarth, P., Sonek, S., Coryell, J. C., Nguyen, T. M., Nardocci, N., Zorzi, G., Rodriguez, D., Desguerre, I., Bertini, E., Simonati, A., Levinson, B., Dias, C., Barbot, C., Carrilho, I., Santos, M., Malik, I., & 2 othersGitschier, J. & Hayflick, S. J., Oct 28 2008, In: Neurology. 71, 18, p. 1402-1409 8 p.

Research output: Contribution to journal › Article › peer-review

213 Scopus citations

Neuroinflammation and oxidation/nitration of α-synuclein linked to dopaminergic neurodegeneration

Gao, H. M., Kotzbauer, P. T., Uryu, K., Leight, S., Trojanowski, J. Q. & Lee, V. M. Y., Jul 23 2008, In: Journal of Neuroscience. 28, 30, p. 7687-7698 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

239 Scopus citations

Neurturin, a novel neurotrophic factor, is localized to mouse chromosome 17 and human chromosome 19p13.3

Heuckeroth, R. O., Kotzbauer, P., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., Zimonjic, D. B., Popescu, N. C., Johnson, E. M. & Milbrandt, J., Aug 15 1997, In: Genomics. 44, 1, p. 137-140 4 p.

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Neurturin, a relative of glial-cell-line-derived neurotrophic factor

Kotzbauer, P. T., Lampe, P. A., Heuckeroth, R. O., Golden, J. P., Creedon, D. J., Johnson, E. M. & Milbrandt, J., Dec 5 1996, In: Nature. 384, 6608, p. 467-470 4 p.

Research output: Contribution to journal › Article › peer-review

651 Scopus citations

Non-classical nuclear localization signal peptides for high efficiency lipofection of primary neurons and neuronal cell lines

Ma, H., Zhu, J., Maronski, M., Kotzbauer, P. T., Lee, V. Y., Dichter, M. A. & Diamond, S. L., Jun 12 2002, In: Neuroscience. 112, 1, p. 1-5 5 p.

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Optimal promoter usage for lentiviral vector-mediated transduction of cultured central nervous system cells

Li, M., Husic, N., Lin, Y., Christensen, H., Malik, I., McIver, S., Daniels, C. M. L. P., Harris, D. A., Kotzbauer, P. T., Goldberg, M. P. & Snider, B. J., May 2010, In: Journal of Neuroscience Methods. 189, 1, p. 56-64 9 p.

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Parkinson’s disease and multiple system atrophy have distinct -synuclein seed characteristics

Yamasaki, T. R., Holmes, B. B., Furman, J. L., Dhavale, D. D., Su, B. W., Song, E. S., Cairns, N. J., Kotzbauer, P. T. & Diamond, M. I., Jan 18 2019, In: Journal of Biological Chemistry. 294, 3, p. 1045-1058 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

95 Scopus citations

Partial deficit of pantothenate kinase 2 catalytic activity in a case of tremor-predominant neurodegeneration with brain iron accumulation

Liang, T. W., Truax, A. C., Trojanowski, J. Q., Lee, V. M. Y., Stern, M. B. & Kotzbauer, P. T., May 1 2006, In: Movement Disorders. 21, 5, p. 718-722 5 p.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Pathologic accumulation of α-synuclein and Aβ in Parkinson disease patients with dementia

Kotzbauer, P. T., Cairns, N. J., Campbell, M. C., Willis, A. W., Racette, B. A., Tabbal, S. D. & Perlmutter, J. S., Oct 2012, In: Archives of neurology. 69, 10, p. 1326-1331 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

139 Scopus citations

Persephin, a novel neurotrophic factor related to GDNF and neurturin

Milbrandt, J., De Sauvage, F. J., Fahrner, T. J., Baloh, R. H., Leitner, M. L., Tansey, M. G., Lampe, P. A., Heuckeroth, R. O., Kotzbauer, P. T., Simburger, K. S., Golden, J. P., Davies, J. A., Vejsada, R., Kato, A. C., Hynes, M., Sherman, D., Nishimura, M., Wang, L. C., Vandlen, R., Moffat, B., & 7 othersKlein, R. D., Poulsen, K., Gray, C., Garces, A., Henderson, C. E., Phillips, H. S. & Johnson, E. M., Feb 1998, In: Neuron. 20, 2, p. 245-253 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

440 Scopus citations

Postnatal development of survival responsiveness in rat sympathetic neurons to leukemia inhibitory factor and ciliary neurotrophic factor

Kotzbauer, P. T., Lampe, P. A., Estus, S., Milbrandt, J. & Johnson, E. M., Apr 1994, In: Neuron. 12, 4, p. 763-773 11 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Proteinopathy and longitudinal changes in functional connectivity networks in Parkinson disease

Campbell, M. C., Jackson, J. J., Koller, J. M., Snyder, A. Z., Kotzbauer, P. T. & Perlmutter, J. S., Feb 18 2020, In: Neurology. 94, 7, p. e718-e728

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Proteinopathy and Longitudinal Cognitive Decline in Parkinson Disease

Myers, P. S., O'Donnell, J. L., Jackson, J. J., Lessov-Schlaggar, C. N., Miller, R. L., Foster, E. R., Cruchaga, C., Benitez, B. A., Kotzbauer, P. T., Perlmutter, J. S. & Campbell, M. C., Jul 5 2022, In: Neurology. 99, 1, p. E66-E76

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Quantifying regional α -synuclein, amyloid β, and tau accumulation in lewy body dementia

Miller, R. L., Dhavale, D. D., O’Shea, J. Y., Andruska, K. M., Liu, J., Franklin, E. E., Buddhala, C., Loftin, S. K., Cirrito, J. R., Perrin, R. J., Cairns, N. J., Campbell, M., Perlmutter, J. S. & Kotzbauer, P. T., Feb 2022, In: Annals of Clinical and Translational Neurology. 9, 2, p. 106-121 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

Radiosynthesis and in vivo evaluation of two PET radioligands for imaging α-synuclein

Zhang, X., Jin, H., Padakanti, P. K., Li, J., Yang, H., Fan, J., Mach, R. H., Kotzbauer, P. & Tu, Z., Mar 1 2014, In: Applied Sciences (Switzerland). 4, 1, p. 66-78 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

28 Scopus citations

Resonance assignments of an α-synuclein fibril prepared in Tris buffer at moderate ionic strength

Barclay, A. M., Dhavale, D. D., Courtney, J. M., Kotzbauer, P. T. & Rienstra, C. M., Apr 1 2018, In: Biomolecular NMR Assignments. 12, 1, p. 195-199 5 p.

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Selective expression of an acetylcholine receptor-lacZ transgene in synaptic nuclei of adult muscle fibers

Sanes, J. R., Johnson, Y. R., Kotzbauer, P. T., Mudd, J., Hanley, T., Martinou, J. C. & Merlie, J. P., Dec 1 1991, In: Development. 113, 4, p. 1181-1191 11 p.

Research output: Contribution to journal › Article › peer-review

161 Scopus citations

Sleep Deprivation Affects Tau Phosphorylation in Human Cerebrospinal Fluid

Barthélemy, N. R., Liu, H., Lu, W., Kotzbauer, P. T., Bateman, R. J. & Lucey, B. P., May 1 2020, In: Annals of neurology. 87, 5, p. 700-709 10 p.

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Paul Kotzbauer

Research output

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