Research output per year
Research output per year
- 1 - 50 out of 62 results
Search results
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2023
A clarion call for high-quality research on gender dysphoric youth
Hruz, P. W., Nov 2023, In: Acta Paediatrica, International Journal of Paediatrics. 112, 11, p. 2266-2268 3 p.Research output: Contribution to journal › Editorial
Open Access1 Scopus citations -
Quantitative determination of SLC2A1 variant functional effects in GLUT1 deficiency syndrome
Tayebi, N., Leon-Ricardo, B., McCall, K., Mehinovic, E., Engelstad, K., Huynh, V., Turner, T. N., Weisenberg, J., Thio, L. L., Hruz, P., Williams, R. S. B., De Vivo, D. C., Petit, V., Haller, G. & Gurnett, C. A., May 2023, In: Annals of Clinical and Translational Neurology. 10, 5, p. 787-801 15 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
2022
Muscle-Specific Ablation of Glucose Transporter 1 (GLUT1) Does Not Impair Basal or Overload-Stimulated Skeletal Muscle Glucose Uptake
McMillin, S. L., Evans, P. L., Taylor, W. M., Weyrauch, L. A., Sermersheim, T. J., Welc, S. S., Heitmeier, M. R., Hresko, R. C., Hruz, P. W., Koumanov, F., Holman, G. D., Abel, E. D. & Witczak, C. A., Dec 2022, In: Biomolecules. 12, 12, 1734.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
2021
Letter to the Editor from William J. Malone et al: "Proper Care of Transgender and Gender-diverse Persons in the Setting of Proposed Discrimination: A Policy Perspective"
Malone, W. J., Hruz, P. W., Mason, J. W. & Beck, S., Aug 1 2021, In: Journal of Clinical Endocrinology and Metabolism. 106, 8, p. E3287-E3288Research output: Contribution to journal › Letter › peer-review
Open Access6 Scopus citations -
2020
Deficiencies in Scientific Evidence for Medical Management of Gender Dysphoria
Hruz, P. W., Feb 1 2020, In: Linacre Quarterly. 87, 1, p. 34-42 9 p.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations -
Lactotrehalose, an Analog of Trehalose, Increases Energy Metabolism Without Promoting Clostridioides difficile Infection in Mice
Zhang, Y., Shaikh, N., Ferey, J. L., Wankhade, U. D., Chintapalli, S. V., Higgins, C. B., Crowley, J. R., Heitmeier, M. R., Stothard, A. I., Mihi, B., Good, M., Higashiyama, T., Swarts, B. M., Hruz, P. W., Shankar, K., Tarr, P. I. & DeBosch, B. J., Apr 2020, In: Gastroenterology. 158, 5, p. 1402-1416.e2Research output: Contribution to journal › Article › peer-review
Open Access27 Scopus citations -
2019
Identification of druggable small molecule antagonists of the Plasmodium falciparum hexose transporter PfHT and assessment of ligand access to the glucose permeation pathway via FLAG-mediated protein engineering
Heitmeier, M. R., Hresko, R. C., Edwards, R. L., Prinsen, M. J., Ilagan, M. X. G., Odom John, A. R. & Hruz, P. W., May 2019, In: PloS one. 14, 5, e0216457.Research output: Contribution to journal › Article › peer-review
Open Access16 Scopus citations -
2018
Contribution of systemic inflammation to permanence of katp-induced neonatal diabetes in mice
Emfinger, C. H., Yan, Z., Welscher, A., Hung, P., McAllister, W., Hruz, P. W., Nichols, C. G. & Remedi, M. S., Dec 2018, In: American Journal of Physiology - Endocrinology and Metabolism. 315, 6, p. E1121-E1132Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Evaluating the efficacy of GLUT inhibitors using a seahorse extracellular flux analyzer
Wei, C., Heitmeier, M., Hruz, P. W. & Shanmugam, M., 2018, Methods in Molecular Biology. Humana Press Inc., p. 69-75 7 p. (Methods in Molecular Biology; vol. 1713).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
5 Scopus citations -
Letter to the Editor: "endocrine Treatment of Gender-Dysphoric/Gender-Incongruent Persons: An Endocrine Society Clinical Practice Guideline"
Laidlaw, M. K., Van Meter, Q. L., Hruz, P. W., Van Mol, A. & Malone, W. J., Dec 28 2018, In: Journal of Clinical Endocrinology and Metabolism. 104, 3, p. 686-687 2 p.Research output: Contribution to journal › Letter › peer-review
Open Access15 Scopus citations -
Metabolic and Cardiac Adaptation to Chronic Pharmacologic Blockade of Facilitative Glucose Transport in Murine Dilated Cardiomyopathy and Myocardial Ischemia
Heitmeier, M. R., Payne, M. A., Weinheimer, C., Kovacs, A., Hresko, R. C., Jay, P. Y. & Hruz, P. W., Dec 1 2018, In: Scientific reports. 8, 1, 6475.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
TFEB-dependent induction of thermogenesis by the hepatocyte SLC2A inhibitor trehalose
Zhang, Y., Higgins, C. B., Mayer, A. L., Mysorekar, I. U., Razani, B., Graham, M. J., Hruz, P. W. & DeBosch, B. J., Nov 2 2018, In: Autophagy. 14, 11, p. 1959-1975 17 p.Research output: Contribution to journal › Article › peer-review
Open Access24 Scopus citations -
2017
Development of GLUT4-selective antagonists for multiple myeloma therapy
Wei, C., Bajpai, R., Sharma, H., Heitmeier, M., Jain, A. D., Matulis, S. M., Nooka, A. K., Mishra, R. K., Hruz, P. W., Schiltz, G. E. & Shanmugam, M., Oct 20 2017, In: European Journal of Medicinal Chemistry. 139, p. 573-586 14 p.Research output: Contribution to journal › Article › peer-review
40 Scopus citations -
MEPicides: Potent antimalarial prodrugs targeting isoprenoid biosynthesis
Edwards, R. L., Brothers, R. C., Wang, X., Maron, M. I., Ziniel, P. D., Tsang, P. S., Kraft, T. E., Hruz, P. W., Williamson, K. C., Dowd, C. S. & John, A. R. O., Dec 1 2017, In: Scientific reports. 7, 1, 8400.Research output: Contribution to journal › Article › peer-review
Open Access25 Scopus citations -
2016
A novel fluorescence resonance energy transfer-based screen in high-throughput format to identify inhibitors of malarial and human glucose transporters
Kraft, T. E., Heitmeier, M. R., Putanko, M., Edwards, R. L., Ilagan, M. X. G., Payne, M. A., Autry, J. M., Thomas, D. D., Odom, A. R. & Hruz, P. W., Dec 2016, In: Antimicrobial agents and chemotherapy. 60, 12, p. 7407-7414 8 p.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations -
Mammalian glucose transporter activity is dependent upon anionic and conical phospholipids
Hresko, R. C., Kraft, T. E., Quigley, A., Carpenter, E. P. & Hruz, P. W., Aug 12 2016, In: Journal of Biological Chemistry. 291, 33, p. 17271-17282 12 p.Research output: Contribution to journal › Article › peer-review
Open Access50 Scopus citations -
SLC2A8 (GLUT8) is a mammalian trehalose transporter required for trehalose-induced autophagy
Mayer, A. L., Higgins, C. B., Heitmeier, M. R., Kraft, T. E., Qian, X., Crowley, J. R., Hyrc, K. L., Beatty, W. L., Yarasheski, K. E., Hruz, P. W. & Debosch, B. J., Dec 6 2016, In: Scientific reports. 6, 38586.Research output: Contribution to journal › Article › peer-review
Open Access85 Scopus citations -
Trehalose inhibits solute carrier 2A (SLC2A) proteins to induce autophagy and prevent hepatic steatosis
DeBosch, B. J., Heitmeier, M. R., Mayer, A. L., Higgins, C. B., Crowley, J. R., Kraft, T. E., Chi, M., Newberry, E. P., Chen, Z., Finck, B. N., Davidson, N. O., Yarasheski, K. E., Hruz, P. W. & Moley, K. H., Feb 23 2016, In: Science signaling. 9, 416, RA21.Research output: Contribution to journal › Article › peer-review
Open Access227 Scopus citations -
2015
Clinical case study: Commentary
Hruz, P. W., Dec 2015, In: Clinical chemistry. 61, 12, p. 1444 1 p.Research output: Contribution to journal › Comment/debate
Open Access -
Commentary
Hruz, P., Dec 1 2015, In: Clinical chemistry. 61, 12, 1 p.Research output: Contribution to journal › Comment/debate
Open Access -
Expression, purification, and functional characterization of the insulin-responsive facilitative glucose transporter GLUT4
Kraft, T. E., Hresko, R. C. & Hruz, P. W., Dec 1 2015, In: Protein Science. 24, 12, p. 2008-2019 12 p.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations -
In Silico Modeling-based Identification of Glucose Transporter 4 (GLUT4)-selective Inhibitors for Cancer Therapy
Mishra, R. K., Wei, C., Hresko, R. C., Bajpai, R., Heitmeier, M., Matulis, S. M., Nooka, A. K., Rosen, S. T., Hruz, P. W., Schiltz, G. E. & Shanmugam, M., Jun 5 2015, In: Journal of Biological Chemistry. 290, 23, p. 14441-14453 13 p.Research output: Contribution to journal › Article › peer-review
Open Access62 Scopus citations -
The glucose transporter PfHT1 is an antimalarial target of the HIV protease inhibitor lopinavir
Kraft, T. E., Armstrong, C., Heitmeier, M. R., Odom, A. R. & Hruz, P. W., Oct 1 2015, In: Antimicrobial agents and chemotherapy. 59, 10, p. 6203-6209 7 p.Research output: Contribution to journal › Article › peer-review
Open Access21 Scopus citations -
2014
HIV and Endocrine Disorders
Hruz, P. W., Sep 2014, In: Endocrinology and Metabolism Clinics of North America. 43, 3, p. xvii-xviiiResearch output: Contribution to journal › Editorial
3 Scopus citations -
Isoform-selective inhibition of facilitative glucose transporters: Elucidation of the molecular mechanism of HIV protease inhibitor binding
Hresko, R. C., Kraft, T. E., Tzekov, A., Wildman, S. A. & Hruz, P. W., Jun 6 2014, In: Journal of Biological Chemistry. 289, 23, p. 16100-16113 14 p.Research output: Contribution to journal › Article › peer-review
Open Access16 Scopus citations -
2012
GLUT4, GLUT1, and GLUT8 are the dominant GLUT transcripts expressed in the murine left ventricle
Aerni-Flessner, L., Abi-Jaoude, M., Koenig, A., Payne, M. & Hruz, P. W., Jun 8 2012, In: Cardiovascular Diabetology. 11, 63.Research output: Contribution to journal › Article › peer-review
Open Access66 Scopus citations -
Saxagliptin improves glucose tolerance but not survival in a murine model of dilated cardiomyopathy
Vyas, A. K., Aerni-Flessner, L. B., Payne, M. A., Kovacs, A., Jay, P. Y. & Hruz, P. W., Dec 2012, In: Cardiovascular Endocrinology. 1, 4, p. 74-82 9 p.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
2011
Acute sulfonylurea therapy at disease onset can cause permanent remission of K ATP-induced diabetes
Remedi, M. S., Agapova, S. E., Vyas, A. K., Hruz, P. W. & Nichols, C. G., Oct 2011, In: Diabetes. 60, 10, p. 2515-2522 8 p.Research output: Contribution to journal › Article › peer-review
Open Access31 Scopus citations -
Exenatide improves glucose homeostasis and prolongs survival in a murine model of dilated cardiomyopathy
Kalla Vyas, A., Yang, K. C., Woo, D., Tzekov, A., Kovacs, A., Jay, P. Y. & Hruz, P. W., 2011, In: PloS one. 6, 2, e17178.Research output: Contribution to journal › Article › peer-review
Open Access56 Scopus citations -
GS-8374, a novel HIV protease inhibitor, does not alter glucose homeostasis in cultured adipocytes or in a healthy-rodent model system
Hruz, P. W., Yan, Q., Tsai, L., Koster, J., Xu, L., Cihlar, T. & Callebaut, C., Apr 2011, In: Antimicrobial agents and chemotherapy. 55, 4, p. 1377-1382 6 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
HIV protease inhibitors act as competitive inhibitors of the cytoplasmic glucose binding site of GLUTs with differing affinities for GLUT1 and GLUT4
Hresko, R. C. & Hruz, P. W., Sep 23 2011, In: PloS one. 6, 9, e25237.Research output: Contribution to journal › Article › peer-review
Open Access75 Scopus citations -
Molecular mechanisms for insulin resistance in treated HIV-infection
Hruz, P. W., Jun 2011, In: Best Practice and Research: Clinical Endocrinology and Metabolism. 25, 3, p. 459-468 10 p.Research output: Contribution to journal › Review article › peer-review
43 Scopus citations -
2010
Effects of the HIV protease inhibitor ritonavir on GLUT4 knock-out mice
Vyas, A. K., Koster, J. C., Tzekov, A. & Hruz, P. W., Nov 19 2010, In: Journal of Biological Chemistry. 285, 47, p. 36395-36400 6 p.Research output: Contribution to journal › Article › peer-review
Open Access56 Scopus citations -
Liver regeneration is impaired in lipodystrophic fatty liver dystrophy mice
Gazit, V., Weymann, A., Hartman, E., Finck, B. N., Hruz, P. W., Tzekov, A. & Rudnick, D. A., Dec 2010, In: Hepatology. 52, 6, p. 2109-2117 9 p.Research output: Contribution to journal › Article › peer-review
Open Access62 Scopus citations -
2009
Acipimox, an inhibitor of lipolysis, attenuates atherogenesis in LDLR-Null mice treated with HIV protease inhibitor ritonavir
Guo, W., Wong, S., Pudney, J., Jasuja, R., Hua, N., Jiang, L., Miller, A., Hruz, P. W., Hamilton, J. A. & Bhasin, S., Dec 2009, In: Arteriosclerosis, thrombosis, and vascular biology. 29, 12, p. 2028-2032 5 p.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
Genetic disruption of myostatin reduces the development of proatherogenic dyslipidemia and atherogenic lesions in Ldlr null mice
Tu, P., Bhasin, S., Hruz, P. W., Herbst, K. L., Castellani, L. W., Hua, N., Hamilton, J. A. & Guo, W., Aug 2009, In: Diabetes. 58, 8, p. 1739-1748 10 p.Research output: Contribution to journal › Article › peer-review
Open Access49 Scopus citations -
The role of protease inhibitors in the pathogenesis of HIV-associated lipodystrophy: Cellular mechanisms and clinical implications
Flint, O. P., Noor, M. A., Hruz, P. W., Hylemon, P. B., Yarasheski, K., Kotler, D. P., Parker, R. A. & Bellamine, A., Jan 2009, In: Toxicologic Pathology. 37, 1, p. 65-77 13 p.Research output: Contribution to journal › Review article › peer-review
Open Access83 Scopus citations -
2008
Contribution of metabolic and anthropometric abnormalities to cardiovascular disease risk factors
Grunfeld, C., Kotler, D. P., Arnett, D. K., Falutz, J. M., Haffner, S. M., Hruz, P., Masur, H., Meigs, J. B., Mulligan, K., Reiss, P. & Samaras, K., Jul 8 2008, In: Circulation. 118, 2, p. e20-e28Research output: Contribution to journal › Article › peer-review
Open Access52 Scopus citations -
HIV protease inhibitors and insulin resistance: Lessons from in-vitro, rodent and healthy human volunteer models
Hruz, P. W., Nov 2008, In: Current Opinion in HIV and AIDS. 3, 6, p. 660-665 6 p.Research output: Contribution to journal › Review article › peer-review
38 Scopus citations -
HIV protease inhibitors that block GLUT4 precipitate acute, decompensated heart failure in a mouse model of dilated cardiomyopathy
Hruz, P. W., Yan, Q., Struthers, H. & Jay, P. Y., Jul 2008, In: FASEB Journal. 22, 7, p. 2161-2167 7 p.Research output: Contribution to journal › Article › peer-review
26 Scopus citations -
2006
Rosiglitazone inhibits mouse liver regeneration
Turmelle, Y. P., Shikapwashya, O., Tu, S., Hruz, P. W., Yan, Q. & Rudnick, D. A., Dec 2006, In: FASEB Journal. 20, 14, p. E2117-E2126Research output: Contribution to journal › Article › peer-review
47 Scopus citations -
Tipranavir without ritonavir does not acutely induce peripheral insulin resistance in a rodent model [1]
Hruz, P. W. & Yan, Q., Dec 2006, In: Journal of Acquired Immune Deficiency Syndromes. 43, 5, p. 624-625 2 p.Research output: Contribution to journal › Letter › peer-review
Open Access12 Scopus citations -
2005
Direct comparison of the acute in vivo effects of HIV protease inhibitors on peripheral glucose disposal
Yan, Q. & Hruz, P. W., Dec 2005, In: Journal of Acquired Immune Deficiency Syndromes. 40, 4, p. 398-403 6 p.Research output: Contribution to journal › Article › peer-review
Open Access57 Scopus citations -
2004
A structural basis for the acute effects of HIV protease inhibitors on GLUT4 intrinsic activity
Hertel, J., Struthers, H., Horj, C. B. & Hruz, P. W., Dec 31 2004, In: Journal of Biological Chemistry. 279, 53, p. 55147-55152 6 p.Research output: Contribution to journal › Article › peer-review
Open Access74 Scopus citations -
Delayed hepatocellular mitotic progression and impaired liver regeneration in early growth response-1-deficient mice
Liao, Y., Shikapwashya, O. N., Shteyer, E., Dieckgraefe, B. K., Hruz, P. W. & Rudnick, D. A., Oct 8 2004, In: Journal of Biological Chemistry. 279, 41, p. 43107-43116 10 p.Research output: Contribution to journal › Article › peer-review
Open Access90 Scopus citations -
Disruption of hepatic adipogenesis is associated with impaired liver regeneration in mice
Shteyer, E., Liao, Y., Muglia, L. J., Hruz, P. W. & Rudnick, D. A., Dec 2004, In: Hepatology. 40, 6, p. 1322-1332 11 p.Research output: Contribution to journal › Article › peer-review
Open Access196 Scopus citations -
2003
HIV protease inhibitors acutely impair glucose-stimulated insulin release
Koster, J. C., Remedi, M. S., Qiu, H., Nichols, C. G. & Hruz, P. W., Jul 1 2003, In: Diabetes. 52, 7, p. 1695-1700 6 p.Research output: Contribution to journal › Article › peer-review
Open Access112 Scopus citations -
2002
Indinavir induces acute and reversible peripheral insulin resistance in rats
Hruz, P. W., Murata, H., Qiu, H. & Mueckler, M., 2002, In: Diabetes. 51, 4, p. 937-942 6 p.Research output: Contribution to journal › Article › peer-review
Open Access89 Scopus citations -
Indinavir inhibits the glucose transporter isoform Glut4 at physiologic concentrations
Murata, H., Hruz, P. W. & Mueckler, M., Apr 12 2002, In: AIDS. 16, 6, p. 859-863 5 p.Research output: Contribution to journal › Article › peer-review
Open Access209 Scopus citations -
Investigating the cellular targets of HIV protease inhibitors: Implications for metabolic disorders and improvements in drug therapy
Murata, H., Hruz, P. W. & Mueckler, M., 2002, In: Current Drug Targets - Infectious Disorders. 2, 1, p. 1-8 8 p.Research output: Contribution to journal › Article › peer-review
28 Scopus citations