Paul Hruz

Associate Professor of Pediatrics, Associate Professor of Cell Biology and Physiology

    • 2489 Citations
    1991 …2020

    Research output per year

    If you made any changes in Pure these will be visible here soon.

    Personal profile

    Research interests

    Dr. Hruz is board certified in Pediatrics and Pediatric Endocrinology and Metabolism. Dr. Hruz has clinical interest in a wide range of endocrine disorders, with a special interest in diabetes mellitus. His research efforts are directed toward understanding facilitative glucose transport as it relates to normal and disordered glucose homeostasis. The laboratory is investigating the in vitro and in vivo effects of HIV protease inhibitors on glucose transporter function. The goal of this research is to identify the molecular mechanisms that lead HIV infected patients receiving PIs to develop insulin resistance. The laboratory is also using these isoform-selective antagonists of the insulin-responsive transporter GLUT4 to understand the role of glucose transport in insulin-responsive tissues. Recent efforts have been directed toward understanding the role of glucose transport in the failing heart. This has led to translational research into the understanding of the influence of insulin resistance in pediatric heart failure.

    Areas of Clinical Interest

    Pediatric endocrinology, pediatric metabolism

    Fingerprint Dive into the research topics where Paul Hruz is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

    • 2 Similar Profiles

    Network Recent external collaboration on country level. Dive into details by clicking on the dots.

    Research Output

    Deficiencies in Scientific Evidence for Medical Management of Gender Dysphoria

    Hruz, P. W., Feb 1 2020, In : Linacre Quarterly. 87, 1, p. 34-42 9 p.

    Research output: Contribution to journalArticle

  • 2 Scopus citations

    Lactotrehalose, an Analog of Trehalose, Increases Energy Metabolism Without Promoting Clostridioides difficile Infection in Mice

    Zhang, Y., Shaikh, N., Ferey, J. L., Wankhade, U. D., Chintapalli, S. V., Higgins, C. B., Crowley, J. R., Heitmeier, M. R., Stothard, A. I., Mihi, B., Good, M., Higashiyama, T., Swarts, B. M., Hruz, P. W., Shankar, K., Tarr, P. I. & DeBosch, B. J., Apr 2020, In : Gastroenterology. 158, 5, p. 1402-1416.e2

    Research output: Contribution to journalArticle

  • 2 Scopus citations

    Identification of druggable small molecule antagonists of the Plasmodium falciparum hexose transporter PfHT and assessment of ligand access to the glucose permeation pathway via FLAG-mediated protein engineering

    Heitmeier, M. R., Hresko, R. C., Edwards, R. L., Prinsen, M. J., Ilagan, M. X. G., Odom John, A. R. & Hruz, P. W., May 2019, In : PloS one. 14, 5, e0216457.

    Research output: Contribution to journalArticle

    Open Access
  • 1 Scopus citations

    Contribution of systemic inflammation to permanence of katp-induced neonatal diabetes in mice

    Emfinger, C. H., Yan, Z., Welscher, A., Hung, P., McAllister, W., Hruz, P. W., Nichols, C. G. & Remedi, M. S., Dec 2018, In : American Journal of Physiology - Endocrinology and Metabolism. 315, 6, p. E1121-E1132

    Research output: Contribution to journalArticle

  • Evaluating the efficacy of GLUT inhibitors using a seahorse extracellular flux analyzer

    Wei, C., Heitmeier, M., Hruz, P. W. & Shanmugam, M., Jan 1 2018, Methods in Molecular Biology. Humana Press Inc., p. 69-75 7 p. (Methods in Molecular Biology; vol. 1713).

    Research output: Chapter in Book/Report/Conference proceedingChapter

  • 4 Scopus citations