Paul Bridgman

Professor of Neuroscience, Associate Professor of Biomedical Engineering

    • 3152 Citations
    1979 …2017

    Research output per year

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    Personal profile

    Research interests

    My laboratory focuses on the basic cellular properties of developing nerve and muscle with emphasis on relating structure to function. Several different projects are currently underway. The first involves the mechanism of nerve growth cone locomotion and the relationship between growth cone motility, guidance and nerve outgrowth. The focus of this work is on the mechanoenzymes and cytoskeletal components that are likely to participate in growth cone motility. Cellular and molecular methods are being used to locate and disrupt the activity of mechanoenzymes and cytoskeletal polymers, such as actin filaments and microtubules thought to be important for locomotion. We are also studying the role of the actin cytoskeleton and myosins in the synaptic vesicle recycling. The third projects focuses on developing new techniques to guide growing neurons in cell culture. We have developed a new method of forming substrate patterns that can be produced after cells have been plated. This allows us to change the direction of growth interactively and form simple neuronal circuits.

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    Research Output

    • 3152 Citations
    • 46 Article
    • 6 Review article
    • 2 Chapter

    Using rotary shadow electron microscopy to characterize semaphorin-mediated growth cone collapse

    Bridgman, P. C., Jan 1 2017, In : Methods in Molecular Biology. 1493, p. 185-194 10 p.

    Research output: Contribution to journalArticle

  • Nerve growth factor stimulates axon outgrowth through negative regulation of growth cone actomyosin restraint of microtubule advance

    Turney, S. G., Ahmed, M., Chandrasekar, I., Wysolmerski, R. B., Goeckeler, Z. M., Rioux, R. M., Whitesides, G. M. & Bridgman, P. C., Feb 1 2016, In : Molecular biology of the cell. 27, 3, p. 500-517 18 p.

    Research output: Contribution to journalArticle

  • 19 Scopus citations

    Neurite outgrowth on electrospun nanofibers with uniaxial alignment: The effects of fiber density, surface coating, and supporting substrate

    Xie, J., Liu, W., Macewan, M. R., Bridgman, P. C. & Xia, Y., Feb 25 2014, In : ACS nano. 8, 2, p. 1878-1885 8 p.

    Research output: Contribution to journalArticle

    Open Access
  • 119 Scopus citations

    Nonmuscle myosin II is a critical regulator of clathrin-mediated endocytosis

    Chandrasekar, I., Goeckeler, Z. M., Turney, S. G., Wang, P., Wysolmerski, R. B., Adelstein, R. S. & Bridgman, P. C., Apr 1 2014, In : Traffic. 15, 4, p. 418-432 15 p.

    Research output: Contribution to journalArticle

  • 21 Scopus citations

    Myosin II regulates activity dependent compensatory endocytosis at central synapses

    Chandrasekar, I., Huettner, J. E., Turney, S. G. & Bridgman, P. C., Oct 14 2013, In : Journal of Neuroscience. 33, 41, p. 16131-16145 15 p.

    Research output: Contribution to journalArticle

    Open Access
  • 19 Scopus citations