• Source: Scopus
1979 …2020

Research activity per year

If you made any changes in Pure these will be visible here soon.

Personal profile

Research interests

The research in my laboratory focuses on the recognition of antigen by T cells.   One aspect of our research involves determining the molecular basis for alloreactivity.  We have shown that alloreactivity involves the recognition by the TCR of endogenous peptides bound to allogeneic MHC molecules with a high degree of specificity.  To compare this recognition to conventional TCR recognition of pMHC, we have generated T cells for which we have defined both self and allogeneic ligands.  We have recently shown in a mouse model that T cells expressing two TCRs, have a much higher degree of alloreactivity in vitro and in graft versus host disease, and are now extending these findings to human GvHD patients.

Fingerprint

Dive into the research topics where Paul Allen is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
  • 12 Similar Profiles

Network

Recent external collaboration on country level. Dive into details by clicking on the dots.
If you made any changes in Pure these will be visible here soon.