• 3869 Citations

Research output per year

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Personal profile

Research interests

The human genome is constantly under assault from endogenous and exogenous forms of damage and needs to be repaired to maintain cell viability and prevent oncogenesis. At the same time, DNA damaging agents are used for cancer therapy. Therefore understanding DNA repair is important for both the prevention of cancer as well as its treatment. How do human cells sense DNA damage and activate repair? Are these processes altered in specific disease states? How does the cell promote DNA repair in the context of chromatin and different stages of the cell cycle? We are broadly interested in understanding DNA repair mechanisms and signaling in human cells, and how these processes may be altered in tumors. Our lab uses a variety of biochemical, cell biological, and animal model systems to answer these questions. Ultimately, we hope to apply the knowledge that we gain to improve diagnostic and therapeutic outcomes for cancer.

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Research Output

53BP1 Enforces Distinct Pre- and Post-resection Blocks on Homologous Recombination

Callen, E., Zong, D., Wu, W., Wong, N., Stanlie, A., Ishikawa, M., Pavani, R., Dumitrache, L. C., Byrum, A. K., Mendez-Dorantes, C., Martinez, P., Canela, A., Maman, Y., Day, A., Kruhlak, M. J., Blasco, M. A., Stark, J. M., Mosammaparast, N., McKinnon, P. J. & Nussenzweig, A., Jan 2 2020, In : Molecular cell. 77, 1, p. 26-38.e7

Research output: Contribution to journalArticle

  • 10 Scopus citations

    Barrier-to-autointegration factor 1 protects against a basal cGAS-STING response

    Ma, H., Qian, W., Bambouskova, M., Collins, P. L., Porter, S. I., Byrum, A. K., Zhang, R., Artyomov, M., Oltz, G., Mosammaparast, N., Miner, J. J. & Diamond, M. S., Mar 1 2020, In : mBio. 11, 2, e00136-20.

    Research output: Contribution to journalArticle

    Open Access
  • Defining and Modulating ‘BRCAness’

    Byrum, A. K., Vindigni, A. & Mosammaparast, N., Sep 2019, In : Trends in Cell Biology. 29, 9, p. 740-751 12 p.

    Research output: Contribution to journalReview article

  • 14 Scopus citations

    Intersections between transcription-coupled repair and alkylation damage reversal

    Brickner, J. R., Townley, B. A. & Mosammaparast, N., Sep 2019, In : DNA Repair. 81, 102663.

    Research output: Contribution to journalReview article

  • Mitotic regulators TPX2 and Aurora A protect DNA forks during replication stress by counteracting 53BP1 function

    Byrum, A. K., Carvajal-Maldonado, D., Mudge, M. C., Valle-Garcia, D., Majid, M. C., Patel, R., Sowa, M. E., Gygi, S. P., Wade Harper, J., Shi, Y., Vindigni, A. & Mosammaparast, N., Feb 1 2019, In : Journal of Cell Biology. 218, 2, p. 422-432 11 p.

    Research output: Contribution to journalArticle

  • 6 Scopus citations