Over the last 25 years, Dr. White's research interests have included active participation as a co-investigator and subsequently co-principal investigator of the Diabetes Control and Complications Trial (DCCT) both at Washington University and the University of Michigan. His currently the principal investigator at Washington University for the DCCT/EDIC study. He has had an ongoing interest in the methods of intensive therapy in type 1 and the risk of hypoglycemia as part of this therapy. He also oversees the Diabetes Prevention Program (DPP) and the DPP Outcomes Study (DPPOS), multiple trials of psychosocial interventions in diabetic teenagers, and the local centers of the Type 1 Diabetes TrialNet and TRIGR studies (related to prevention of type 1 diabetes) and the STOPP-T2D/TODAY study (related to treatment and prevention of type 2 diabetes in youth). Recently, Dr. White has been collaborating with Tamara Hershey, PhD, from the Department of Psychiatry to study cognitive functioning in children with type 1 diabetes mellitus. These studies have consistently shown persistent effects of severe hypoglycemia on the long delay Spatial Delayed Response Task (SDR) and suggest an affect of prior hypoglycemia on memory function. Studies are continuing in hopes of confirming and expanding these findings. See http://www.nil.wustl.edu/labs/hershey/db.htm for more information. Dr. White is supported largely by research grants from NIH and JDRF grant on intensive therapy for children with type 1 diabetes. He is also supported by the General Clinical Research Center grant, and various grants from pharmaceutical companies. He is also PI for institutionally-based fellowship training (T32) and career-development (K12) grants from NIDDK.
Endocrinology, metabolism, juvenile diabetes, diabetes mellitus, hypoglycemia, insulin therapy, diabetic behavioral therapy, diabetes management