Nathan Stitziel

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9773

Citations

Research activity per year

Research interests

My research focuses on studying the inherited basis of cardiovascular disease at the intersection of computational biology and human genetics. Using a variety of techniques in genomics and bioinformatics, my laboratory is interested in: 1) Identifying novel genes and pathways underlying both Mendelian and complex forms of disease; 2) Developing innovative computational methods for the analysis of complex genetic data; and 3) Applying insights gained from human genetics to improve patient care.

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Clinical interests

Cardiovascular genetics; inherited cardiovascular disease; genetic syndromes; cardiomyopathy, arrhythmia genetics

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PhD/MSTP Students

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71 Article
14 Review article
5 Comment/debate
3 Letter
More
- 2 Editorial
- 1 Conference contribution

Molecular Regulation and Therapeutic Targeting of VLDL Production in Cardiometabolic Disease
Burks, K. H., Stitziel, N. O. & Davidson, N. O., Jan 2025, In: CMGH. 19, 1, 101409.
Research output: Contribution to journal › Review article › peer-review

Open Access
A genomic mutational constraint map using variation in 76,156 human genomes
Genome Aggregation Database Consortium, Jan 4 2024, In: Nature. 625, 7993, p. 92-100 9 p.
Research output: Contribution to journal › Article › peer-review
258 Scopus citations
ANGPTL3 deficiency impairs lipoprotein production and produces adaptive changes in hepatic lipid metabolism
Burks, K. H., Xie, Y., Gildea, M., Jung, I. H., Mukherjee, S., Lee, P., Pudupakkam, U., Wagoner, R., Patel, V., Santana, K., Alisio, A., Goldberg, I. J., Finck, B. N., Fisher, E. A., Davidson, N. & Stitziel, N. O., Feb 2024, In: Journal of lipid research. 65, 2, 100500.
Research output: Contribution to journal › Article › peer-review

Open Access
7 Scopus citations
Author Correction: A genomic mutational constraint map using variation in 76,156 human genomes (Nature, (2024), 625, 7993, (92-100), 10.1038/s41586-023-06045-0)
Genome Aggregation Database Consortium, Chen, S., Francioli, L. C., Goodrich, J. K., Collins, R. L., Kanai, M., Wang, Q., Alföldi, J., Watts, N. A., Vittal, C., Gauthier, L. D., Poterba, T., Wilson, M. W., Tarasova, Y., Phu, W., Grant, R., Yohannes, M. T., Koenig, Z., Farjoun, Y. & Banks, E. & 181 others, Donnelly, S., Gabriel, S., Gupta, N., Ferriera, S., Tolonen, C., Novod, S., Bergelson, L., Roazen, D., Ruano-Rubio, V., Covarrubias, M., Llanwarne, C., Petrillo, N., Wade, G., Jeandet, T., Munshi, R., Tibbetts, K., Abreu, M., Aguilar Salinas, C. A., Ahmad, T., Albert, C. M., Ardissino, D., Armean, I. M., Atkinson, E. G., Atzmon, G., Barnard, J., Baxter, S. M., Beaugerie, L., Benjamin, E. J., Benjamin, D., Boehnke, M., Bonnycastle, L. L., Bottinger, E. P., Bowden, D. W., Bown, M. J., Brand, H., Brant, S., Brookings, T., Bryant, S., Calvo, S. E., Campos, H., Chambers, J. C., Chan, J. C., Chao, K. R., Chapman, S., Chasman, D. I., Chisholm, R., Cho, J., Chowdhury, R., Chung, M. K., Chung, W. K., Cibulskis, K., Cohen, B., Connolly, K. M., Correa, A., Cummings, B. B., Dabelea, D., Danesh, J., Darbar, D., Darnowsky, P., Denny, J., Duggirala, R., Dupuis, J., Ellinor, P. T., Elosua, R., Emery, J., England, E., Erdmann, J., Esko, T., Evangelista, E., Fatkin, D., Florez, J., Franke, A., Fu, J., Färkkilä, M., Garimella, K., Gentry, J., Getz, G., Glahn, D. C., Glaser, B., Glatt, S. J., Goldstein, D., Gonzalez, C., Groop, L., Gudmundsson, S., Haessly, A., Haiman, C., Hall, I., Hanis, C. L., Harms, M., Hiltunen, M., Holi, M. M., Hultman, C. M., Jalas, C., Kallela, M., Kaplan, D., Kaprio, J., Kathiresan, S., Kenny, E. E., Kim, B. J., Kim, Y. J., King, D., Kirov, G., Kooner, J., Koskinen, S., Krumholz, H. M., Kugathasan, S., Kwak, S. H., Laakso, M., Lake, N., Langsford, T., Laricchia, K. M., Lehtimäki, T., Lek, M., Lipscomb, E., Loos, R. J. F., Lu, W., Lubitz, S. A., Luna, T. T., Ma, R. C. W., Marcus, G. M., Marrugat, J., Mattila, K. M., McCarroll, S., McCarthy, M. I., McCauley, J. L., McGovern, D., McPherson, R., Meigs, J. B., Melander, O., Metspalu, A., Meyers, D., Minikel, E. V., Mitchell, B. D., Mootha, V. K., Naheed, A., Nazarian, S., Nilsson, P. M., O’Donovan, M. C., Okada, Y., Ongur, D., Orozco, L., Owen, M. J., Palmer, C., Palmer, N. D., Palotie, A., Park, K. S., Pato, C., Pulver, A. E., Rader, D., Rahman, N., Reiner, A., Remes, A. M., Rhodes, D., Rich, S., Rioux, J. D., Ripatti, S., Roden, D. M., Rotter, J. I., Sahakian, N., Saleheen, D., Salomaa, V., Saltzman, A., Samani, N. J., Samocha, K. E., Sanchis-Juan, A., Scharf, J., Schleicher, M., Schunkert, H., Schönherr, S., Seaby, E. G., Shah, S. H., Shand, M., Sharpe, T., Shoemaker, M. B., Shyong, T., Silverman, E. K., Singer-Berk, M., Sklar, P., Smith, J. T., Smith, J. G. & Stitziel, N. O., Feb 1 2024, In: Nature. 626, 7997, p. E1
Research output: Contribution to journal › Comment/debate

Open Access
7 Scopus citations
Deciphering the impact of genomic variation on function
UM1HG011969, UM1HG011966, Single Cell, QTL/Statgen, Phenotypic Impact and Function, Neuro, Noncoding Variants, MPRA, iPSC, Impact on Diverse Populations, Immune, Imaging, Evolution, Enumerating Variants, Defining and Systematizing Function, CRISPR, Coding Variants, Cellular Programs and Networks, Cardiometabolic & Standards and Pipelines & 61 others, Networks, Mapping, Project Design, Computational Analysis, Modeling, and Prediction, Characterization, Catalog, Code of Conduct Committee (alphabetical by last name), Steering Committee Co-Chairs (alphabetical by last name), IGVF Consortium, NHGRI Program Management (alphabetical by last name), IGVF Affiliate Member Projects (contact PIs, other members (alphabetical by last name)), Data and Administrative Coordinating Center Awards (contact PI, MPIs (alphabetical by last name), other members (alphabetical by last name)), Network Projects (contact PI, MPIs (alphabetical by last name), other members (alphabetical by last name)), Predictive Modeling Awards (contact PI, MPIs (alphabetical by last name), other members (alphabetical by last name)), Mapping Awards (contact PI, MPIs (alphabetical by last name), other members (alphabetical by last name)), Characterization Awards (contact PI, MPIs (alphabetical by last name), other members (alphabetical by last name)), Working Group and Focus Group Co-Chairs (alphabetical by last name), Writing group (ordered by contribution), Yi lab, Xu lab, Seruggia lab, Sanjana lab, Reilly lab, Ray lab, Pollard lab, Pennacchio and Visel lab, Mostafavi lab, Moore lab, Jones lab, Heinig lab, Gupta lab, Grimes lab, Gazal lab, Dey lab, Ciccia lab, Brennand lab, U24HG012070, U24HG012012, U01HG012103, U01HG012079, U01HG012059, U01HG012051, U01HG012047, U01HG012041, U01HG012069, U01HG012064, U01HG012039, U01HG012022, U01HG012009, U01HG011967, U01HG011952, UM1HG012077, UM1HG012076, UM1HG011986, UM1HG012053, UM1HG012010, UM1HG012003, UM1HG011996, UM1HG011989, UM1HG011972 & Samer, E. K., Sep 5 2024, In: Nature. 633, 8028, p. 47-57 11 p.
Research output: Contribution to journal › Article › peer-review
2 Scopus citations

Nathan Stitziel

Personal profile

Research interests

Clinical interests

Available to Mentor:

Fingerprint

Collaborations and top research areas from the last five years

Dive into details

Molecular Regulation and Therapeutic Targeting of VLDL Production in Cardiometabolic Disease

A genomic mutational constraint map using variation in 76,156 human genomes

ANGPTL3 deficiency impairs lipoprotein production and produces adaptive changes in hepatic lipid metabolism

Author Correction: A genomic mutational constraint map using variation in 76,156 human genomes (Nature, (2024), 625, 7993, (92-100), 10.1038/s41586-023-06045-0)

Deciphering the impact of genomic variation on function

Nathan Stitziel

Personal profile

Research interests

Clinical interests

Available to Mentor:

Fingerprint

Collaborations and top research areas from the last five years

Research output

Molecular Regulation and Therapeutic Targeting of VLDL Production in Cardiometabolic Disease

A genomic mutational constraint map using variation in 76,156 human genomes

ANGPTL3 deficiency impairs lipoprotein production and produces adaptive changes in hepatic lipid metabolism

Author Correction: A genomic mutational constraint map using variation in 76,156 human genomes (Nature, (2024), 625, 7993, (92-100), 10.1038/s41586-023-06045-0)

Deciphering the impact of genomic variation on function