Personal profile
Research interests
Our laboratory is interested in understanding the molecular pathways that regulate the success and failure of engineered T cell therapies for cancer. Through investigation of the interactions between chimeric antigen receptor (CAR) T cells and blood cancer cells, we aim to define the molecular events that permit successful target cell clearance, or alternatively lead to the development of T cell dysfunction.
Clinical interests
Aggressive blood cancers, cellular therapies
Available to Mentor:
- PhD Students
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Collaborations and top research areas from the last five years
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BACH2 regulates T cell lineage state to enhance CAR T cell function
Chang, T. C., Heard, A., Lattin, J., Warrington, J. M., Barrett, A., Landmann, J. H., Tenzin, Y., Ganesh, V., Thompson, B., Afrin, S., Gupta, D. K., Chang, J. F., Ritchey, J., Selli, M. E., Hsu, Y. S., Song, H., Federico, A. J., Horn, A., Meers, M. P. & Weber, E. W. & 6 others, , Mar 2026, In: Nature immunology. 27, 3, p. 413-424 12 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Link opens in a new tab Scopus citations -
Diurnal rhythm in chimeric antigen receptor T cell effectiveness in an observational study of 715 patients
Lyons, P. G., Gill, E., Kumar, P., Beasley, M., Park-Egan, B., Lokhandwala, Z. A., Lebold, K. M., Hayes-Lattin, B., Hough, C. L., Singh, N., Hazan, G., Mok, H., Huss, J. M., McEvoy, C. A. & Haspel, J. A., Feb 9 2026, In: JCI Insight. 11, 3Research output: Contribution to journal › Article › peer-review
Open Access1 Link opens in a new tab Scopus citations -
Disarming myeloid resistance in CAR T therapy
Warrington, J. M. & Singh, N., Aug 11 2025, In: Cancer Cell. 43, 8, p. 1392-1393 2 p.Research output: Contribution to journal › Comment/debate
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Analysis of pre-treatment tumors reveals gatekeepers of response to CAR T cells
Singh, N., Mar 6 2024, In: Molecular Therapy. 32, 3, p. 567-568 2 p.Research output: Contribution to journal › Comment/debate
Open Access2 Link opens in a new tab Scopus citations -
Approval of the first TCR-based cell therapy
Singh, N., Oct 2 2024, In: Molecular Therapy. 32, 10, p. 3195 1 p.Research output: Contribution to journal › Editorial
Open Access8 Link opens in a new tab Scopus citations