Research output per year
Research output per year
Personal profile
Research interests
Our laboratory is interested in understanding the molecular pathways that regulate the success and failure of engineered T cell therapies for cancer. Through investigation of the interactions between chimeric antigen receptor (CAR) T cells and blood cancer cells, we aim to define the molecular events that permit successful target cell clearance, or alternatively lead to the development of T cell dysfunction.
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Antigen glycosylation regulates efficacy of CAR T cells targeting CD19
Heard, A., Landmann, J. H., Hansen, A. R., Papadopolou, A., Hsu, Y. S., Selli, M. E., Warrington, J. M., Lattin, J., Chang, J., Ha, H., Haug-Kroeper, M., Doray, B., Gill, S., Ruella, M., Hayer, K. E., Weitzman, M. D., Green, A. M., Fluhrer, R. & Singh, N., Dec 2022, In: Nature communications. 13, 1, 3367.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Antigen-specific depletion of CD4+ T cells by CAR T cells reveals distinct roles of higher- and lower-affinity TCRs during autoimmunity
Yi, J., Miller, A. T., Archambault, A. S., Jones, A. J., Bradstreet, T. R., Bandla, S., Hsu, Y. S., Edelson, B. T., Zhou, Y. W., Fremont, D. H., Egawa, T., Singh, N., Wu, G. F. & Hsieh, C. S., Oct 2022, In: Science immunology. 7, 76, eabo0777.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Discovery of a novel genomic alteration that renders leukemic cells resistant to CD19-targeted immunotherapies
Ghobadi, A., Landmann, J. H., Carter, A., Cooper, M. L., Selli, M. E., Chang, J., Baker, M., Miller, C. A., Ferraro, F., Chen, D. Y., Smith, A. M., LaValle, T. A., Duncavage, E. J., Chou, J., Tam, V., Benoun, J. M., Nater, J., Scholler, N., Milletti, F., Vezan, R., & 3 others, Oct 25 2022, In: Blood Advances. 6, 20, p. 5634-5640 7 p.Research output: Contribution to journal › Letter › peer-review
Open Access -
Mechanisms of Resistance and Relapse After CAR-T Cell Therapy
Selli, M. E., Dalal, P., Neelapu, S. S. & Singh, N., 2022, Cancer Drug Discovery and Development. Humana Press Inc., p. 207-219 13 p. (Cancer Drug Discovery and Development).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
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Advances in CAR design
Heard, A., Chang, J., Warrington, J. M. & Singh, N., Sep 2021, In: Best Practice and Research: Clinical Haematology. 34, 3, 101304.Research output: Contribution to journal › Review article › peer-review
2 Scopus citations