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Research interests

Our laboratory is interested in understanding the molecular pathways that regulate the success and failure of engineered T cell therapies for cancer. Through investigation of the interactions between chimeric antigen receptor (CAR) T cells and blood cancer cells, we aim to define the molecular events that permit successful target cell clearance, or alternatively lead to the development of T cell dysfunction.

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  • Antigen glycosylation regulates efficacy of CAR T cells targeting CD19

    Heard, A., Landmann, J. H., Hansen, A. R., Papadopolou, A., Hsu, Y. S., Selli, M. E., Warrington, J. M., Lattin, J., Chang, J., Ha, H., Haug-Kroeper, M., Doray, B., Gill, S., Ruella, M., Hayer, K. E., Weitzman, M. D., Green, A. M., Fluhrer, R. & Singh, N., Dec 2022, In: Nature communications. 13, 1, 3367.

    Research output: Contribution to journalArticlepeer-review

    Open Access
  • Mechanisms of Resistance and Relapse After CAR-T Cell Therapy

    Selli, M. E., Dalal, P., Neelapu, S. S. & Singh, N., 2022, Cancer Drug Discovery and Development. Humana Press Inc., p. 207-219 13 p. (Cancer Drug Discovery and Development).

    Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

  • Advances in CAR design

    Heard, A., Chang, J., Warrington, J. M. & Singh, N., Sep 2021, In: Best Practice and Research: Clinical Haematology. 34, 3, 101304.

    Research output: Contribution to journalReview articlepeer-review

    1 Scopus citations
  • An NK-like CAR T cell transition in CAR T cell dysfunction

    Good, C. R., Aznar, M. A., Kuramitsu, S., Samareh, P., Agarwal, S., Donahue, G., Ishiyama, K., Wellhausen, N., Rennels, A. K., Ma, Y., Tian, L., Guedan, S., Alexander, K. A., Zhang, Z., Rommel, P. C., Singh, N., Glastad, K. M., Richardson, M. W., Watanabe, K., Tanyi, J. L. & 10 others, O'Hara, M. H., Ruella, M., Lacey, S. F., Moon, E. K., Schuster, S. J., Albelda, S. M., Lanier, L. L., Young, R. M., Berger, S. L. & June, C. H., Dec 9 2021, In: Cell. 184, 25, p. 6081-6100.e26

    Research output: Contribution to journalArticlepeer-review

    12 Scopus citations
  • Antigen-independent activation enhances the efficacy of 4-1BB-costimulated CD22 CAR T cells

    Singh, N., Frey, N. V., Engels, B., Barrett, D. M., Shestova, O., Ravikumar, P., Cummins, K. D., Lee, Y. G., Pajarillo, R., Chun, I., Shyu, A., Highfill, S. L., Price, A., Zhao, L., Peng, L., Granda, B., Ramones, M., Lu, X. M., Christian, D. A., Perazzelli, J. & 16 others, Lacey, S. F., Roy, N. H., Burkhardt, J. K., Colomb, F., Damra, M., Abdel-Mohsen, M., Liu, T., Liu, D., Standley, D. M., Young, R. M., Brogdon, J. L., Grupp, S. A., June, C. H., Maude, S. L., Gill, S. & Ruella, M., May 2021, In: Nature medicine. 27, 5, p. 842-850 9 p.

    Research output: Contribution to journalArticlepeer-review

    17 Scopus citations