Research output per year
Research output per year
Personal profile
Research interests
Our laboratory is interested in understanding the molecular pathways that regulate the success and failure of engineered T cell therapies for cancer. Through investigation of the interactions between chimeric antigen receptor (CAR) T cells and blood cancer cells, we aim to define the molecular events that permit successful target cell clearance, or alternatively lead to the development of T cell dysfunction.
Available to Mentor:
- PhD/MSTP Students
Fingerprint
Dive into the research topics where Nathan Singh is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
-
Analysis of pre-treatment tumors reveals gatekeepers of response to CAR T cells
Singh, N., Mar 6 2024, In: Molecular Therapy. 32, 3, p. 567-568 2 p.Research output: Contribution to journal › Comment/debate
-
Costimulatory domains direct distinct fates of CAR-driven T-cell dysfunction
Selli, M. E., Landmann, J. H., Terekhova, M., Lattin, J., Heard, A., Hsu, Y. S., Chang, T. C., Chang, J., Warrington, J., Ha, H., Kingston, N., Hogg, G., Slade, M., Berrien-Elliott, M. M., Foster, M., Kersting-Schadek, S., Gruszczynska, A., DeNardo, D., Fehniger, T. A. & Artyomov, M. & 1 others, , Jun 29 2023, In: Blood. 141, 26, p. 3153-3165 13 p.Research output: Contribution to journal › Article › peer-review
20 Scopus citations -
Efficacy of checkpoint inhibition after CAR-T failure in aggressive B-cell lymphomas: outcomes from 15 US institutions
Major, A., Yu, J., Shukla, N., Che, Y., Karrison, T. G., Treitman, R., Kamdar, M. K., Haverkos, B. M., Godfrey, J., Babcook, M. A., Voorhees, T. J., Carlson, S., Gaut, D., Oliai, C., Romancik, J. T., Winter, A. M., Hill, B. T., Bansal, R., Bisneto, J. C. V. & Nizamuddin, I. A. & 15 others, , Aug 16 2023, In: Blood Advances. 7, 16, p. 4528-4538 11 p.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations -
Inducing T cell dysfunction by chronic stimulation of CAR-engineered T cells targeting cancer cells in suspension cultures
Selli, M. E., Landmann, J. H., Arveseth, C. & Singh, N., Mar 17 2023, In: STAR Protocols. 4, 1, 101954.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Intrinsic tumor resistance to CAR T cells is a dynamic transcriptional state that is exploitable with low-dose radiation
Kim, A. B., Chou, S. Y., Kang, S., Kwon, E., Inkman, M., Szymanski, J., Andruska, N., Colgan, C., Zhang, J., Yang, J. C., Singh, N. & DeSelm, C. J., Sep 26 2023, In: Blood Advances. 7, 18, p. 5396-5408 13 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations