Research output per year
Research output per year
Personal profile
Research interests
Our laboratory is interested in understanding the molecular pathways that regulate the success and failure of engineered T cell therapies for cancer. Through investigation of the interactions between chimeric antigen receptor (CAR) T cells and blood cancer cells, we aim to define the molecular events that permit successful target cell clearance, or alternatively lead to the development of T cell dysfunction.
Available to Mentor:
- PhD/MSTP Students
Fingerprint
Dive into the research topics where Nathan Singh is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
-
Analysis of pre-treatment tumors reveals gatekeepers of response to CAR T cells
Singh, N., Mar 6 2024, In: Molecular Therapy. 32, 3, p. 567-568 2 p.Research output: Contribution to journal › Comment/debate
Open Access1 Scopus citations -
Approval of the first TCR-based cell therapy
Singh, N., Oct 2 2024, In: Molecular Therapy. 32, 10, p. 3195 1 p.Research output: Contribution to journal › Editorial
2 Scopus citations -
Identification of Core Techniques That Enhance Genome Editing of Human T Cells Expressing Synthetic Antigen Receptors
Chang, J. F., Wellhausen, N., Engel, N. W., Landmann, J. H., Hopkins, C. R., Salas-McKee, J., Bear, A. S., Selli, M. E., Agarwal, S., Jadlowsky, J. K., Linette, G. P., Gill, S., June, C. H., Fraietta, J. A. & Singh, N., Sep 1 2024, In: Cancer immunology research. 12, 9, p. 1136-1146 11 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Rational Protein Engineering to Enhance MHC-Independent T-cell Receptors
Chang, J. F., Landmann, J. H., Chang, T. C., Selli, M. E., Tenzin, Y., Warrington, J. M., Ritchey, J., Hsu, Y. S., Slade, M., Gupta, D. K., Dipersio, J. F., Holehouse, A. S. & Singh, N., Nov 1 2024, In: Cancer discovery. 14, 11, p. 2109-2121 13 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Regulatory Considerations for Genome-Edited T-cell Therapies
Jadlowsky, J. K., Chang, J. F., Spencer, D., Warrington, J. M., Levine, B. L., June, C. H., Fraietta, J. A. & Singh, N., Sep 1 2024, In: Cancer immunology research. 12, 9, p. 1132-1135 4 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations