Research Output per year
Research Output per year
Personal profile
Research interests
Our laboratory is interested in understanding the molecular pathways that regulate the success and failure of engineered T cell therapies for cancer. Through investigation of the interactions between chimeric antigen receptor (CAR) T cells and blood cancer cells, we aim to define the molecular events that permit successful target cell clearance, or alternatively lead to the development of T cell dysfunction.
Fingerprint
Dive into the research topics where Nathan Singh is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 16 Similar Profiles
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Research Output
-
Impaired death receptor signaling in leukemia causes antigen-independent resistance by inducing CAR T-cell dysfunction
Singh, N., Lee, Y. G., Shestova, O., Ravikumar, P., Hayer, K. E., Hong, S. J., Lu, X. M., Pajarillo, R., Agarwal, S., Kuramitsu, S., Orlando, E. J., Mueller, K. T., Good, C. R., Berger, S. L., Shalem, O., Weitzman, M. D., Frey, N. V., Maude, S. L., Grupp, S. A., June, C. H. & 2 others, , Apr 2020, In: Cancer discovery. 10, 4, p. 552-567 16 p.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
Ionizable Lipid Nanoparticle-Mediated mRNA Delivery for Human CAR T Cell Engineering
Billingsley, M. M., Singh, N., Ravikumar, P., Zhang, R., June, C. H. & Mitchell, M. J., Mar 11 2020, In: Nano Letters. 20, 3, p. 1578-1589 12 p.Research output: Contribution to journal › Article › peer-review
15 Scopus citations -
Boosting engineered T cells
Singh, N. & June, C. H., Jan 1 2019, In: Science. 365, 6449, p. 119-120 2 p.Research output: Contribution to journal › Review article › peer-review
3 Scopus citations -
Mechanisms of resistance to CAR T cell therapies
Singh, N., Orlando, E., Xu, J., Xu, J., Binder, Z., Collins, M. A., O'Rourke, D. M. & Melenhorst, J. J., Jan 1 2019, (Accepted/In press) In: Seminars in Cancer Biology.Research output: Contribution to journal › Review article › peer-review
2 Scopus citations -
Erythropoietic protoporphyria in an adult with sequential liver and hematopoietic stem cell transplantation: A case report
Windon, A. L., Tondon, R., Singh, N., Abu-Gazala, S., Porter, D. L., Russell, J. E., Cook, C., Lander, E., Smith, G., Olthoff, K. M., Shaked, A., Hoteit, M., Furth, E. E. & Serper, M., Mar 2018, In: American Journal of Transplantation. 18, 3, p. 745-749 5 p.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations