• 722 Citations

Research output per year

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Personal profile

Research interests

Our laboratory is interested in understanding the molecular pathways that regulate the success and failure of engineered T cell therapies for cancer. Through investigation of the interactions between chimeric antigen receptor (CAR) T cells and blood cancer cells, we aim to define the molecular events that permit successful target cell clearance, or alternatively lead to the development of T cell dysfunction.

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Research Output

  • 722 Citations
  • 11 Article
  • 9 Review article
  • 1 Letter

Impaired death receptor signaling in leukemia causes antigen-independent resistance by inducing CAR T-cell dysfunction

Singh, N., Lee, Y. G., Shestova, O., Ravikumar, P., Hayer, K. E., Hong, S. J., Lu, X. M., Pajarillo, R., Agarwal, S., Kuramitsu, S., Orlando, E. J., Mueller, K. T., Good, C. R., Berger, S. L., Shalem, O., Weitzman, M. D., Frey, N. V., Maude, S. L., Grupp, S. A., June, C. H. & 2 others, Gill, S. & Ruella, M., Apr 2020, In : Cancer discovery. 10, 4, p. 552-567 16 p.

Research output: Contribution to journalArticle

Open Access
  • 7 Scopus citations

    Ionizable Lipid Nanoparticle-Mediated mRNA Delivery for Human CAR T Cell Engineering

    Billingsley, M. M., Singh, N., Ravikumar, P., Zhang, R., June, C. H. & Mitchell, M. J., Mar 11 2020, In : Nano Letters. 20, 3, p. 1578-1589 12 p.

    Research output: Contribution to journalArticle

  • 6 Scopus citations

    Boosting engineered T cells

    Singh, N. & June, C. H., Jan 1 2019, In : Science. 365, 6449, p. 119-120 2 p.

    Research output: Contribution to journalReview article

    2 Scopus citations

    Mechanisms of resistance to CAR T cell therapies

    Singh, N., Orlando, E., Xu, J., Xu, J., Binder, Z., Collins, M. A., O'Rourke, D. M. & Melenhorst, J. J., Jan 1 2019, (Accepted/In press) In : Seminars in Cancer Biology.

    Research output: Contribution to journalReview article

  • 1 Scopus citations

    Erythropoietic protoporphyria in an adult with sequential liver and hematopoietic stem cell transplantation: A case report

    Windon, A. L., Tondon, R., Singh, N., Abu-Gazala, S., Porter, D. L., Russell, J. E., Cook, C., Lander, E., Smith, G., Olthoff, K. M., Shaked, A., Hoteit, M., Furth, E. E. & Serper, M., Mar 2018, In : American Journal of Transplantation. 18, 3, p. 745-749 5 p.

    Research output: Contribution to journalArticle

    Open Access
  • 10 Scopus citations