Research output per year
Research output per year
Personal profile
Research interests
Our laboratory is interested in understanding the molecular pathways that regulate the success and failure of engineered T cell therapies for cancer. Through investigation of the interactions between chimeric antigen receptor (CAR) T cells and blood cancer cells, we aim to define the molecular events that permit successful target cell clearance, or alternatively lead to the development of T cell dysfunction.
Available to Mentor:
- PhD/MSTP Students
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Collaborations and top research areas from the last five years
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Costimulatory domains direct distinct fates of CAR-driven T-cell dysfunction
Selli, M. E., Landmann, J. H., Terekhova, M., Lattin, J., Heard, A., Hsu, Y. S., Chang, T. C., Chang, J., Warrington, J., Ha, H., Kingston, N., Hogg, G., Slade, M., Berrien-Elliott, M. M., Foster, M., Kersting-Schadek, S., Gruszczynska, A., DeNardo, D., Fehniger, T. A., Artyomov, M., & 1 others, Jun 29 2023, In: Blood. 141, 26, p. 3153-3165 13 p.Research output: Contribution to journal › Article › peer-review
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Inducing T cell dysfunction by chronic stimulation of CAR-engineered T cells targeting cancer cells in suspension cultures
Selli, M. E., Landmann, J. H., Arveseth, C. & Singh, N., Mar 17 2023, In: STAR Protocols. 4, 1, 101954.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Antigen glycosylation regulates efficacy of CAR T cells targeting CD19
Heard, A., Landmann, J. H., Hansen, A. R., Papadopolou, A., Hsu, Y. S., Selli, M. E., Warrington, J. M., Lattin, J., Chang, J., Ha, H., Haug-Kroeper, M., Doray, B., Gill, S., Ruella, M., Hayer, K. E., Weitzman, M. D., Green, A. M., Fluhrer, R. & Singh, N., Dec 2022, In: Nature communications. 13, 1, 3367.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations -
Antigen-specific depletion of CD4+ T cells by CAR T cells reveals distinct roles of higher- and lower-affinity TCRs during autoimmunity
Yi, J., Miller, A. T., Archambault, A. S., Jones, A. J., Bradstreet, T. R., Bandla, S., Hsu, Y. S., Edelson, B. T., Zhou, Y. W., Fremont, D. H., Egawa, T., Singh, N., Wu, G. F. & Hsieh, C. S., Oct 2022, In: Science immunology. 7, 76, eabo0777.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
Discovery of a novel genomic alteration that renders leukemic cells resistant to CD19-targeted immunotherapies
Ghobadi, A., Landmann, J. H., Carter, A., Cooper, M. L., Selli, M. E., Chang, J., Baker, M., Miller, C. A., Ferraro, F., Chen, D. Y., Smith, A. M., LaValle, T. A., Duncavage, E. J., Chou, J., Tam, V., Benoun, J. M., Nater, J., Scholler, N., Milletti, F., Vezan, R., & 3 others, Oct 25 2022, In: Blood Advances. 6, 20, p. 5634-5640 7 p.Research output: Contribution to journal › Letter › peer-review
Open Access