Nathan Singh

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Nathan Singh

Assistant Professor of Medicine

 https://orcid.org/0000-0002-0350-7574
    • Source: Scopus
    20102022

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    Research interests

    Our laboratory is interested in understanding the molecular pathways that regulate the success and failure of engineered T cell therapies for cancer. Through investigation of the interactions between chimeric antigen receptor (CAR) T cells and blood cancer cells, we aim to define the molecular events that permit successful target cell clearance, or alternatively lead to the development of T cell dysfunction.

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    • Antigen glycosylation regulates efficacy of CAR T cells targeting CD19

      Heard, A., Landmann, J. H., Hansen, A. R., Papadopolou, A., Hsu, Y. S., Selli, M. E., Warrington, J. M., Lattin, J., Chang, J., Ha, H., Haug-Kroeper, M., Doray, B., Gill, S., Ruella, M., Hayer, K. E., Weitzman, M. D., Green, A. M., Fluhrer, R. & Singh, N., Dec 2022, In: Nature communications. 13, 1, 3367.

      Research output: Contribution to journal › Article › peer-review

      Open Access

    • Mechanisms of Resistance and Relapse After CAR-T Cell Therapy

      Selli, M. E., Dalal, P., Neelapu, S. S. & Singh, N., 2022, Cancer Drug Discovery and Development. Humana Press Inc., p. 207-219 13 p. (Cancer Drug Discovery and Development).

      Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

    • Advances in CAR design

      Heard, A., Chang, J., Warrington, J. M. & Singh, N., Sep 2021, In: Best Practice and Research: Clinical Haematology. 34, 3, 101304.

      Research output: Contribution to journal › Review article › peer-review

      1 Scopus citations

    • An NK-like CAR T cell transition in CAR T cell dysfunction

      Good, C. R., Aznar, M. A., Kuramitsu, S., Samareh, P., Agarwal, S., Donahue, G., Ishiyama, K., Wellhausen, N., Rennels, A. K., Ma, Y., Tian, L., Guedan, S., Alexander, K. A., Zhang, Z., Rommel, P. C., Singh, N., Glastad, K. M., Richardson, M. W., Watanabe, K., Tanyi, J. L. & 10 others, O'Hara, M. H., Ruella, M., Lacey, S. F., Moon, E. K., Schuster, S. J., Albelda, S. M., Lanier, L. L., Young, R. M., Berger, S. L. & June, C. H., Dec 9 2021, In: Cell. 184, 25, p. 6081-6100.e26

      Research output: Contribution to journal › Article › peer-review

      12 Scopus citations

    • Antigen-independent activation enhances the efficacy of 4-1BB-costimulated CD22 CAR T cells

      Singh, N., Frey, N. V., Engels, B., Barrett, D. M., Shestova, O., Ravikumar, P., Cummins, K. D., Lee, Y. G., Pajarillo, R., Chun, I., Shyu, A., Highfill, S. L., Price, A., Zhao, L., Peng, L., Granda, B., Ramones, M., Lu, X. M., Christian, D. A., Perazzelli, J. & 16 others, Lacey, S. F., Roy, N. H., Burkhardt, J. K., Colomb, F., Damra, M., Abdel-Mohsen, M., Liu, T., Liu, D., Standley, D. M., Young, R. M., Brogdon, J. L., Grupp, S. A., June, C. H., Maude, S. L., Gill, S. & Ruella, M., May 2021, In: Nature medicine. 27, 5, p. 842-850 9 p.

      Research output: Contribution to journal › Article › peer-review

      17 Scopus citations
    View all 27 Research outputs