Research Output per year
Research Output per year
Personal profile
Research interests
Our research identified the membrane protein CD36 as a high affinity receptor for long chain fatty acid (FA) and as a signaling protein that plays a key role in metabolic regulation. We recently documented that CD36-mediated signal transduction involves modulation of the assembly/disassembly of proteins in the AMPK and insulin signaling pathways and we are exploring how this affects activity of downstream proteins of FA and glucose metabolism. In humans, we found that variants in the CD36 gene influence blood lipids and risk of metabolic syndrome and more recently endothelial function. We will be exploring the contribution of CD36 polymorphisms to the susceptibility for endothelial dysfunction, a condition that often precedes insulin resistance, inflammation and onset of metabolic pathologies.
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Research Output
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A single bout of resistance exercise improves postprandial lipid metabolism in overweight/obese men with prediabetes
Bittel, A. J., Bittel, D. C., Mittendorfer, B., Patterson, B. W., Okunade, A. L., Yoshino, J., Porter, L. C., Abumrad, N. A., Reeds, D. N. & Cade, W. T., Mar 1 2020, In : Diabetologia. 63, 3, p. 611-623 13 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Lipokine 5-PAhsA is regulated by adipose triglyceride lipase and primes adipocytes for de novo lipogenesis in mice
Paluchova, V., Oseeva, M., Brezinova, M., Cajka, T., Bardova, K., Adamcova, K., Zacek, P., Brejchova, K., Balas, L., Chodounska, H., Kudova, E., Schreiber, R., Zechner, R., Durand, T., Rossmeisl, M., Abumrad, N. A., Kopecky, J. & Kuda, O., Mar 1 2020, In : Diabetes. 69, 3, p. 300-312 13 p.Research output: Contribution to journal › Article › peer-review
7 Scopus citations -
Myeloid-specific Asxl2 deletion limits diet-induced obesity by regulating energy expenditure
Zou, W., Rohatgi, N., Brestoff, J. R., Moley, J. R., Li, Y., Williams, J. W., Alippe, Y., Pan, H., Pietka, T. A., Mbalaviele, G., Newberry, E. P., Davidson, N. O., Dey, A., Shoghi, K. I., Head, R. D., Wickline, S. A., Randolph, G. J., Abumrad, N. A. & Teitelbaum, S. L., May 1 2020, In : Journal of Clinical Investigation. 130, 5, p. 2644-2656 13 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Fatty acid 2-hydroxylation inhibits tumor growth and increases sensitivity to cisplatin in gastric cancer
Yao, Y., Yang, X., Sun, L., Sun, S., Huang, X., Zhou, D., Li, T., Zhang, W., Abumrad, N. A., Zhu, X., He, S. & Su, X., Mar 2019, In : EBioMedicine. 41, p. 256-267 12 p.Research output: Contribution to journal › Article › peer-review
Open Access16 Scopus citations -
Regulation of lipophagy in NAFLD by cellular metabolism and CD36
Samovski, D. & Abumrad, N. A., 2019, In : Journal of lipid research. 60, 4, p. 755-757 3 p.Research output: Contribution to journal › Comment/debate
3 Scopus citations