Our research identified the membrane protein CD36 as a high affinity receptor for long chain fatty acid (FA) and as a signaling protein that plays a key role in metabolic regulation. We recently documented that CD36-mediated signal transduction involves modulation of the assembly/disassembly of proteins in the AMPK and insulin signaling pathways and we are exploring how this affects activity of downstream proteins of FA and glucose metabolism. In humans, we found that variants in the CD36 gene influence blood lipids and risk of metabolic syndrome and more recently endothelial function. We will be exploring the contribution of CD36 polymorphisms to the susceptibility for endothelial dysfunction, a condition that often precedes insulin resistance, inflammation and onset of metabolic pathologies.

I have mentored numerous students and fellows who have moved on to highly successful careers in science. I prioritize mentoring and devote significant and consistent effort to it. Many of my mentees have been from various minority or ethnic groups and many were women. I strongly believe that the work environment should be positive and enjoyable for everyone, that all members should integrate well in the group and make an effort to be considerate and helpful to each other.