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Nada Abumrad

Robert C Atkins Professor of Obesity Research in Medicine, Professor of Cell Biology and Physiology

  • 14142 Citations
1978 …2020

Research output per year

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Research interests

Our research identified the membrane protein CD36 as a high affinity receptor for long chain fatty acid (FA) and as a signaling protein that plays a key role in metabolic regulation. We recently documented that CD36-mediated signal transduction involves modulation of the assembly/disassembly of proteins in the AMPK and insulin signaling pathways and we are exploring how this affects activity of downstream proteins of FA and glucose metabolism. In humans, we found that variants in the CD36 gene influence blood lipids and risk of metabolic syndrome and more recently endothelial function. We will be exploring the contribution of CD36 polymorphisms to the susceptibility for endothelial dysfunction, a condition that often precedes insulin resistance, inflammation and onset of metabolic pathologies.

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Research Output

A single bout of resistance exercise improves postprandial lipid metabolism in overweight/obese men with prediabetes

Bittel, A. J., Bittel, D. C., Mittendorfer, B., Patterson, B. W., Okunade, A. L., Yoshino, J., Porter, L. C., Abumrad, N. A., Reeds, D. N. & Cade, W. T., Mar 1 2020, In : Diabetologia. 63, 3, p. 611-623 13 p.

Research output: Contribution to journal › Article

    • 1 Scopus citations

    Lipokine 5-PAhsA is regulated by adipose triglyceride lipase and primes adipocytes for de novo lipogenesis in mice

    Paluchova, V., Oseeva, M., Brezinova, M., Cajka, T., Bardova, K., Adamcova, K., Zacek, P., Brejchova, K., Balas, L., Chodounska, H., Kudova, E., Schreiber, R., Zechner, R., Durand, T., Rossmeisl, M., Abumrad, N. A., Kopecky, J. & Kuda, O., Mar 1 2020, In : Diabetes. 69, 3, p. 300-312 13 p.

    Research output: Contribution to journal › Article

    • 6 Scopus citations

    Myeloid-specific Asxl2 deletion limits diet-induced obesity by regulating energy expenditure

    Zou, W., Rohatgi, N., Brestoff, J. R., Moley, J. R., Li, Y., Williams, J. W., Alippe, Y., Pan, H., Pietka, T. A., Mbalaviele, G., Newberry, E. P., Davidson, N. O., Dey, A., Shoghi, K. I., Head, R. D., Wickline, S. A., Randolph, G. J., Abumrad, N. A. & Teitelbaum, S. L., May 1 2020, In : Journal of Clinical Investigation. 130, 5, p. 2644-2656 13 p.

    Research output: Contribution to journal › Article

    Open Access
    • 1 Scopus citations

    Fatty acid 2-hydroxylation inhibits tumor growth and increases sensitivity to cisplatin in gastric cancer

    Yao, Y., Yang, X., Sun, L., Sun, S., Huang, X., Zhou, D., Li, T., Zhang, W., Abumrad, N. A., Zhu, X., He, S. & Su, X., Mar 2019, In : EBioMedicine. 41, p. 256-267 12 p.

    Research output: Contribution to journal › Article

    Open Access
    • 11 Scopus citations

    Regulation of lipophagy in NAFLD by cellular metabolism and CD36

    Samovski, D. & Abumrad, N. A., Jan 1 2019, In : Journal of lipid research. 60, 4, p. 755-757 3 p.

    Research output: Contribution to journal › Comment/debate

    2 Scopus citations