Research output per year
Research output per year
Personal profile
Research interests
We use imaging methods to visualize the spatio temporal dynamics of GPCR mediated signaling activity in living mammalian cells and in identifying the role that the spatio temporal changes play in cellular physiology. We are also interested in identifying GPCR mediated signaling events that regulate cell proliferation and cellular senescence that play roles in cancer and aging.
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An optogenetic model reveals cell shape regulation through FAK and fascin
Castillo-Badillo, J. A. & Gautam, N., Jul 2021, In: Journal of cell science. 134, 13, jcs258321.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
A photoswitchable GPCR-based opsin for presynaptic inhibition
Copits, B. A., Gowrishankar, R., O'Neill, P. R., Li, J. N., Girven, K. S., Yoo, J. J., Meshik, X., Parker, K. E., Spangler, S. M., Elerding, A. J., Brown, B. J., Shirley, S. E., Ma, K. K. L., Vasquez, A. M., Stander, M. C., Kalyanaraman, V., Vogt, S. K., Samineni, V. K., Patriarchi, T., Tian, L. & 4 others, , Jun 2 2021, In: Neuron. 109, 11, p. 1791-1809.e11Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations -
Live Cell Imaging and Optogenetics-Based Assays for GPCR Activity
Meshik, X. & Gautam, N., 2021, Methods in Molecular Biology. Humana Press Inc., p. 207-221 15 p. (Methods in Molecular Biology; vol. 2268).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
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SRRF-Stream Imaging of Optogenetically Controlled Furrow Formation Shows Localized and Coordinated Endocytosis and Exocytosis Mediating Membrane Remodeling
Castillo-Badillo, J. A., Bandi, A. C., Harlalka, S. & Gautam, N., Apr 17 2020, In: ACS synthetic biology. 9, 4, p. 902-919 18 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
Optogenetic control of cytokinesis shows that polarized trafficking governs the process
Castillo-Badillo, J. A., Meshik, X., Harlalka, S. & Gautam, N., 2019, Optogenetics and Optical Manipulation 2019. Jansen, E. D. & Mohanty, S. K. (eds.). SPIE, 1086609. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 10866).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review