Research output per year
Research output per year
Personal profile
Research interests
We use imaging methods to visualize the spatio temporal dynamics of GPCR mediated signaling activity in living mammalian cells and in identifying the role that the spatio temporal changes play in cellular physiology. We are also interested in identifying GPCR mediated signaling events that regulate cell proliferation and cellular senescence that play roles in cancer and aging.
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Research output
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SRRF-Stream Imaging of Optogenetically Controlled Furrow Formation Shows Localized and Coordinated Endocytosis and Exocytosis Mediating Membrane Remodeling
Castillo-Badillo, J. A., Bandi, A. C., Harlalka, S. & Gautam, N., Apr 17 2020, In: ACS synthetic biology. 9, 4, p. 902-919 18 p.Research output: Contribution to journal › Article › peer-review
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Optogenetic control of cytokinesis shows that polarized trafficking governs the process
Castillo-Badillo, J. A., Meshik, X., Harlalka, S. & Gautam, N., Jan 1 2019, Optogenetics and Optical Manipulation 2019. Jansen, E. D. & Mohanty, S. K. (eds.). SPIE, 1086609. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 10866).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review
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Physical Plasma Membrane Perturbation Using Subcellular Optogenetics Drives Integrin-Activated Cell Migration
Meshik, X., O'Neill, P. R. & Gautam, N., Mar 15 2019, In: ACS synthetic biology. 8, 3, p. 498-510 13 p.Research output: Contribution to journal › Article › peer-review
6 Scopus citations -
Membrane Flow Drives an Adhesion-Independent Amoeboid Cell Migration Mode
O'Neill, P. R., Castillo-Badillo, J. A., Meshik, X., Kalyanaraman, V., Melgarejo, K. & Gautam, N., Jul 2 2018, In: Developmental cell. 46, 1, p. 9-22.e4Research output: Contribution to journal › Article › peer-review
37 Scopus citations -
Optogenetic control of cell migration
Meshik, X., O’Neill, P. R. & Gautam, N., Jan 1 2018, Methods in Molecular Biology. Humana Press Inc., p. 313-324 12 p. (Methods in Molecular Biology; vol. 1749).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
5 Scopus citations