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N Gautam

Professor of Anesthesiology, Professor of Genetics

    • 4559 Citations
    1988 …2020

    Research output per year

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    Personal profile

    Research interests

    We use imaging methods to visualize the spatio temporal dynamics of GPCR mediated signaling activity in living mammalian cells and in identifying the role that the spatio temporal changes play in cellular physiology. We are also interested in identifying GPCR mediated signaling events that regulate cell proliferation and cellular senescence that play roles in cancer and aging.

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    Research Output

    SRRF-Stream Imaging of Optogenetically Controlled Furrow Formation Shows Localized and Coordinated Endocytosis and Exocytosis Mediating Membrane Remodeling

    Castillo-Badillo, J. A., Bandi, A. C., Harlalka, S. & Gautam, N., Apr 17 2020, In : ACS synthetic biology. 9, 4, p. 902-919 18 p.

    Research output: Contribution to journal › Article

    • Optogenetic control of cytokinesis shows that polarized trafficking governs the process

    Castillo-Badillo, J. A., Meshik, X., Harlalka, S. & Gautam, N., Jan 1 2019, Optogenetics and Optical Manipulation 2019. Jansen, E. D. & Mohanty, S. K. (eds.). SPIE, 1086609. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 10866).

    Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

    • Physical Plasma Membrane Perturbation Using Subcellular Optogenetics Drives Integrin-Activated Cell Migration

    Meshik, X., O'Neill, P. R. & Gautam, N., Mar 15 2019, In : ACS synthetic biology. 8, 3, p. 498-510 13 p.

    Research output: Contribution to journal › Article

    • 6 Scopus citations

    Membrane Flow Drives an Adhesion-Independent Amoeboid Cell Migration Mode

    O'Neill, P. R., Castillo-Badillo, J. A., Meshik, X., Kalyanaraman, V., Melgarejo, K. & Gautam, N., Jul 2 2018, In : Developmental cell. 46, 1, p. 9-22.e4

    Research output: Contribution to journal › Article

    • 34 Scopus citations

    Optogenetic control of cell migration

    Meshik, X., O’Neill, P. R. & Gautam, N., Jan 1 2018, Methods in Molecular Biology. Humana Press Inc., p. 313-324 12 p. (Methods in Molecular Biology; vol. 1749).

    Research output: Chapter in Book/Report/Conference proceeding › Chapter

    • 4 Scopus citations