Research output per year
Research output per year
Personal profile
Research interests
Specific metabolic requirements of immune cells provide novel promising targets of therapeutic intervention to modulate inflammatory diseases. Bambouskova lab studies how metabolic regulation integrates with immune cell signaling. During her postdoctoral work Monika focused on metabolic rewiring in activating macrophages, particularly on the role of metabolite itaconate in regulation of macrophage inflammatory response. Her work defined a fundamentally novel connection between the cellular stress response and IκBζ-mediated inflammatory axis and its therapeutic impact for a number of autoimmune diseases. Ongoing research program in the lab employs molecular biology and biochemistry techniques together with systems approaches to tackle molecular mechanisms of crosstalk between metabolism and cell signaling in the regulation of immune responses.
Available to Mentor:
- PhD/MSTP Students
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Collaborations and top research areas from the last five years
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Liver ACOX1 regulates levels of circulating lipids that promote metabolic health through adipose remodeling
Lu, D., He, A., Tan, M., Mrad, M., El Daibani, A., Hu, D., Liu, X., Kleiboeker, B., Che, T., Hsu, F. F., Bambouskova, M., Semenkovich, C. F. & Lodhi, I. J., Dec 2024, In: Nature communications. 15, 1, 4214.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
Tetraspanin CD53 Promotes Inflammation but Restrains Mucus Production in a Mouse Model of Allergic Airway Inflammation
Hsu, A. T., Bugajev, V., Gottschalk, T. A., Demkova, L., Potuckova, L., Draberova, L., Bambouskova, M., Hagemann, P., O'Brien, C. A., Riecan, M., Kuda, O., Tsantikos, E., Draber, P., Wright, M. D., van Spriel, A. B., Hibbs, M. L. & Halova, I., 2024, (Accepted/In press) In: Allergy: European Journal of Allergy and Clinical Immunology.Research output: Contribution to journal › Letter › peer-review
Open Access -
Embryonic vitamin D deficiency programs hematopoietic stem cells to induce type 2 diabetes
Oh, J., Riek, A. E., Bauerle, K. T., Dusso, A., McNerney, K. P., Barve, R. A., Darwech, I., Sprague, J. E., Moynihan, C., Zhang, R. M., Kutz, G., Wang, T., Xing, X., Li, D., Mrad, M., Wigge, N. M., Castelblanco, E., Collin, A., Bambouskova, M. & Head, R. D. & 2 others, , Dec 2023, In: Nature communications. 14, 1, 3278.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
Comprehensive Profiling of an Aging Immune System Reveals Clonal GZMK+ CD8+ T Cells as Conserved Hallmark of Inflammaging
Mogilenko, D. A., Shpynov, O., Andhey, P. S., Arthur, L., Swain, A., Esaulova, E., Brioschi, S., Shchukina, I., Kerndl, M., Bambouskova, M., Yao, Z., Laha, A., Zaitsev, K., Burdess, S., Gillfilan, S., Stewart, S. A., Colonna, M. & Artyomov, M. N., Jan 12 2021, In: Immunity. 54, 1, p. 99-115.e12Research output: Contribution to journal › Article › peer-review
Open Access303 Scopus citations -
Crosstalk between ORMDL3, serine palmitoyltransferase, and 5-lipoxygenase in the sphingolipid and eicosanoid metabolic pathways
Bugajev, V., Paulenda, T., Utekal, P., Mrkacek, M., Halova, I., Kuchar, L., Kuda, O., Vavrova, P., Schuster, B., Fuentes-Liso, S., Potuckova, L., Smrz, D., Cernohouzova, S., Draberova, L., Bambouskova, M. & Draber, P., 2021, In: Journal of lipid research. 63, 100121.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations