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Monica Sala-Rabanal

Instructor in Anesthesiology, Instructor in Cell Biology and Physiology

    • 840 Citations
    20032019

    Research output per year

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    Personal profile

    Research interests

    Ion channels and membrane transporters are responsible for communication and exchange processes between and within cells, and underlie phenomena so vital as the generation and propagation of action potentials, or the absorption, distribution and clearance of nutrients and drugs. I am particularly interested in calcium-activated chloride channels (CaCCs, such as TMEM16A) and regulators (CLCAs), and solute and drug transporters, such as organic cation transporters (OCTs) and other members of the SLC family. Using a multidisciplinary approach, which includes biochemical and electrophysiological analyses in primary cells and heterologous expression systems, whole-body positron emission tomography, and in silico modeling, I investigate the structure-function relationships, pharmacology and physiology of these membrane transport proteins, and the functional effect of common polymorphisms and rare mutations. Precise knowledge of the molecular mechanisms governing normal physiology and pathogenesis is essential for the design of specific, successful preventive and therapeutic strategies.

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    Research Output

    • 840 Citations
    • 25 Article
    • 2 Chapter
    • 2 Review article

    ABCC9-related Intellectual disability Myopathy Syndrome is a KATP channelopathy with loss-of-function mutations in ABCC9

    Smeland, M. F., McClenaghan, C., Roessler, H. I., Savelberg, S., Hansen, G. Å. M., Hjellnes, H., Arntzen, K. A., Müller, K. I., Dybesland, A. R., Harter, T., Sala-Rabanal, M., Emfinger, C. H., Huang, Y., Singareddy, S. S., Gunn, J., Wozniak, D. F., Kovacs, A., Massink, M., Tessadori, F., Kamel, S. M. & 5 others, Bakkers, J., Remedi, M. S., Van Ghelue, M., Nichols, C. G. & van Haaften, G., Dec 1 2019, In : Nature communications. 10, 1, 4457.

    Research output: Contribution to journal › Article

    Open Access
    • 3 Scopus citations

    Cantu syndrome-Associated SUR2 (ABCC9) mutations in distinct structural domains result in KATP channel gain-offunction by differential mechanisms

    McClenaghan, C., Hanson, A., Sala-Rabanal, M., Roessler, H. I., Josifova, D., Grange, D. K., Van Haaften, G. & Nichols, C. G., Feb 9 2018, In : Journal of Biological Chemistry. 293, 6, p. 2041-2052 12 p.

    Research output: Contribution to journal › Article

    • 13 Scopus citations

    Cryo-EM and X-ray structures of TRPV4 reveal insight into ion permeation and gating mechanisms

    Deng, Z., Paknejad, N., Maksaev, G., Sala-Rabanal, M., Nichols, C. G., Hite, R. K. & Yuan, P., Mar 1 2018, In : Nature Structural and Molecular Biology. 25, 3, p. 252-260 9 p.

    Research output: Contribution to journal › Article

    • 57 Scopus citations

    Intestinal absorption of glucose in mice as determined by positron emission tomography

    Sala-Rabanal, M., Ghezzi, C., Hirayama, B. A., Kepe, V., Liu, J., Barrio, J. R. & Wright, E. M., Jul 1 2018, In : Journal of Physiology. 596, 13, p. 2473-2489 17 p.

    Research output: Contribution to journal › Article

    Open Access
    • 6 Scopus citations

    Sugar Absorption

    Wright, E. M., Sala-Rabanal, M., Ghezzi, C. & Loo, D. D. F., Mar 28 2018, Physiology of the Gastrointestinal Tract: Sixth Edition. Elsevier Inc., Vol. 2-2. p. 1051-1062 12 p.

    Research output: Chapter in Book/Report/Conference proceeding › Chapter

    • 1 Scopus citations