Mohd Khushman

2023

Mutational analysis of microsatellite-stable gastrointestinal cancer with high tumour mutational burden: a retrospective cohort study

Wang, J., Xiu, J., Farrell, A., Baca, Y., Arai, H., Battaglin, F., Kawanishi, N., Soni, S., Zhang, W., Millstein, J., Shields, A. F., Grothey, A., Weinberg, B. A., Marshall, J. L., Lou, E., Khushman, M., Sohal, D. P. S., Hall, M. J., Liu, T., Oberley, M., & 4 othersSpetzler, D., Korn, W. M., Shen, L. & Lenz, H. J., Feb 2023, In: The Lancet Oncology. 24, 2, p. 151-161 11 p.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Patient-reported geriatric assessment-based frailty index among older adults with gastrointestinal malignancies

Giri, S., Al-Obaidi, M., Harmon, C., Clark, D., Ubersax, C., Dai, C., Young-Smith, C., Outlaw, D., Gbolahan, O., Khushman, M., Bhatia, S. & Williams, G. R., Jan 2023, In: Journal of the American Geriatrics Society. 71, 1, p. 136-144 9 p.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

RNA-seq analysis identifies transcriptomic profiles associated with anal cancer recurrence among people living with HIV

Ye, Y., Maroney, K. J., Wiener, H. W., Mamaeva, O. A., Junkins, A. D., Burkholder, G. A., Sudenga, S. L., Khushman, M., Al Diffalha, S., Bansal, A. & Shrestha, S., 2023, In: Annals of Medicine. 55, 1, 2199366.

Research output: Contribution to journal › Article › peer-review

Open Access

Rural-urban disparities in mortality and geriatric assessment among older adults with cancer: The cancer & aging resilience evaluation (CARE) registry

Fowler, M. E., Kenzik, K. M., Al-Obaidi, M., Harmon, C., Giri, S., Arora, S., Stephenson, C., Khushman, M., Outlaw, D., Bhatia, S. & Williams, G. R., May 2023, In: Journal of Geriatric Oncology. 14, 4, 101505.

Research output: Contribution to journal › Article › peer-review

2022

DCZ0415, a small-molecule inhibitor targeting TRIP13, inhibits EMT and metastasis via inactivation of the FGFR4/STAT3 axis and the Wnt/β-catenin pathway in colorectal cancer

Agarwal, S., Afaq, F., Bajpai, P., Kim, H. G., Elkholy, A., Behring, M., Chandrashekar, D. S., Diffalha, S. A., Khushman, M., Sugandha, S. P., Varambally, S. & Manne, U., Apr 2022, In: Molecular Oncology. 16, 8, p. 1728-1745 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

Detection of mitochondrial DNA mutations in circulating mitochondria-originated extracellular vesicles for potential diagnostic applications in pancreatic adenocarcinoma

Vikramdeo, K. S., Anand, S., Khan, M. A., Khushman, M., Heslin, M. J., Singh, S., Singh, A. P. & Dasgupta, S., Dec 2022, In: Scientific reports. 12, 1, 18455.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

Differences in Pretreatment Frailty Across Gastrointestinal Cancers in Older Adults: Results from the Cancer and Aging Resilience Evaluation Registry

Arora, S., Fowler, M. E., Harmon, C., Al-Obaidi, M., Outlaw, D., Hollis, R., Gbolahan, O., Khushman, MD., Giri, S. & Williams, G. R., Nov 1 2022, In: JCO Oncology Practice. 18, 11, p. E1796-E1806

Research output: Contribution to journal › Article › peer-review

Geriatric Assessment Predictors of 1-Year Mortality in Older Adults With GI Malignancies: A Survival Tree Analysis

Williams, G. R., Dai, C., Giri, S., Al-Obaidi, M., Harmon, C., Kenzik, K. M., McDonald, A., Gbolahan, O., Outlaw, D., Khushman, M., Richman, J. & Bhatia, S., Sep 1 2022, In: JCO Clinical Cancer Informatics. 6, p. e2200065

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Molecular characteristics and clinical outcomes of patients with Neurofibromin 1-altered metastatic colorectal cancer

Arai, H., Elliott, A., Millstein, J., Xiu, J., Ou, F. S., Innocenti, F., Wang, J., Battaglin, F., Jayachandran, P., Kawanishi, N., Soni, S., Zhang, W., Sohal, D., Goldberg, R. M., Hall, M. J., Scott, A. J., Khushman, M., Hwang, J. J., Lou, E., Weinberg, B. A., & 9 othersLockhart, A. C., Shields, A. F., Abraham, J. P., Magee, D., Stafford, P., Zhang, J., Venook, A. P., Korn, W. M. & Lenz, H. J., Jan 5 2022, In: Oncogene. 41, 2, p. 260-267 8 p.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Molecular Characterization of KRAS Wild-type Tumors in Patients with Pancreatic Adenocarcinoma

Philip, P. A., Azar, I., Xiu, J., Hall, M. J., Hendifar, A. E., Lou, E., Hwang, J. J., Gong, J., Feldman, R., Ellis, M., Stafford, P., Spetzler, D., Khushman, MD. M., Sohal, D., Lockhart, A. C., Weinberg, B. A., El-Deiry, W. S., Marshall, J., Shields, A. F. & Korn, W. M., Jun 15 2022, In: Clinical Cancer Research. 28, 12, p. 2704-2714 11 p.

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Neurological complications of GI cancers

Leung, D., Khushman, M. & Junck, L., Jan 1 2022, Neurological Complications of Systemic Cancer and Antineoplastic Therapy. Elsevier, p. 365-386 22 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Pain among older adults with gastrointestinal malignancies- results from the cancer and aging resilience evaluation (CARE) Registry

AL-Obaidi, M., Kosmicki, S., Harmon, C., Lobbous, M., Outlaw, D., Khushman, M., McGwin, G., Bhatia, S., Giri, S. & Williams, G. R., Dec 2022, In: Supportive Care in Cancer. 30, 12, p. 9793-9801 9 p.

Research output: Contribution to journal › Article › peer-review

Perfusion Change of Hepatocellular Carcinoma During Atezolizumab plus Bevacizumab Treatment: A Pilot Study

Onuoha, E., Smith, A. D., Cannon, R., Khushman, M. & Kim, H., 2022, (Accepted/In press) In: Journal of Gastrointestinal Cancer.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Racial disparities in frailty and geriatric assessment impairments in older adults with cancer in the Deep South: Results from the CARE Registry

Williams, G. R., Al-Obaidi, M., Harmon, C., Dai, C., Outlaw, D., Gbolahan, O., Khushman, M., Nyrop, K. A., Gilmore, N., Bhatia, S. & Giri, S., Jun 15 2022, In: Cancer. 128, 12, p. 2313-2319 7 p.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

2021

Clinical and Hematological Predictors of High-Grade Immune-Related Adverse Events Associated With Immune Checkpoint Inhibitors

Manne, A., Mulekar, M. S., Escobar, D. E., Alsayed, A., Sharma, G., Prodduturvar, P., Khushman, M., Howard, J. H., Gilbert, R. & Alkharabsheh, O., 2021, In: Journal of Clinical Medicine Research. 13, 5, p. 268-275 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Distinct genomic landscapes of gastroesophageal adenocarcinoma depending on PD-L1 expression identify mutations in RAS–MAPK pathway and TP53 as potential predictors of immunotherapy efficacy

Wang, J. Y., Xiu, J., Baca, Y., Arai, H., Battaglin, F., Kawanishi, N., Soni, S., Zhang, W., Millstein, J., Shields, A. F., Grothey, A., Weinberg, B. A., Marshall, J. L., Lou, E., Khushman, M., Sohal, D. P. S., Hall, M. J., Oberley, M., Spetzler, D., Shen, L., & 2 othersKorn, W. M. & Lenz, H. J., Jul 2021, In: Annals of Oncology. 32, 7, p. 906-916 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

Genomic landscape of angiosarcoma: A targeted and immunotherapy biomarker analysis

Espejo-Freire, A. P., Elliott, A., Rosenberg, A., Costa, P. A., Barreto-Coelho, P., Jonczak, E., D’amato, G., Subhawong, T., Arshad, J., Diaz-Perez, J. A., Korn, W. M., Oberley, M. J., Magee, D., Dizon, D., von Mehren, M., Khushman, MD. M., Hussein, A. M., Leu, K. & Trent, J. C., Oct 1 2021, In: Cancers. 13, 19, 4816.

Research output: Contribution to journal › Article › peer-review

Open Access

21 Scopus citations

Molecular differences between lymph nodes and distant metastases compared with primaries in colorectal cancer patients

Puccini, A., Seeber, A., Xiu, J., Goldberg, R. M., Soldato, D., Grothey, A., Shields, A. F., Salem, M. E., Battaglin, F., Berger, M. D., El-Deiry, W. S., Tokunaga, R., Naseem, M., Zhang, W., Arora, S. P., Khushman, M. M., Hall, M. J., Philip, P. A., Marshall, J. L., Korn, W. M., & 1 othersLenz, H. J., Dec 2021, In: npj Precision Oncology. 5, 1, 95.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

The impact of neoadjuvant concurrent chemoradiation on exosomal markers (CD63 and CD9) expression and their prognostic significance in patients with rectal adenocarcinoma

Moh'd, K., Prodduturvar, P., Mneimneh, W., Zotto, V. D., Akbar, S., Grimm, L., Rider, P., Hunter, J., Alkharabsheh, O., Patel, G. K., Fabregas, J. C. & Singh, A. P., Jul 20 2021, In: Oncotarget. 12, 15, p. 1490-1498 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

The landscape of alterations in DNA damage response pathways in colorectal cancer

Arai, H., Elliott, A., Xiu, J., Wang, J., Battaglin, F., Kawanishi, N., Soni, S., Zhang, W., Millstein, J., Sohal, D., Goldberg, R. M., Hall, M. J., Scott, A. J., Khushman, M., Hwang, J. J., Lou, E., Weinberg, B. A., Marshall, J. L., Lockhart, A. C., Stafford, P., & 5 othersZhang, J., Moretto, R., Cremolini, C., Korn, W. M. & Lenz, H. J., Jun 1 2021, In: Clinical Cancer Research. 27, 11, p. 3234-3242 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Scopus citations

The prevalence and clinical relevance of 2R/2R TYMS genotype in patients with gastrointestinal malignancies treated with fluoropyrimidine-based chemotherapy regimens

Khushman, M., Patel, G. K., Maharjan, A. S., McMillin, G. A., Nelson, C., Hosein, P. & Singh, A. P., Jun 2021, In: Pharmacogenomics Journal. 21, 3, p. 308-317 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

2020

Comprehensive analysis of expression, clinicopathological association and potential prognostic significance of rabs in pancreatic cancer

Anand, S., Khan, M. A., Khushman, MD., Dasgupta, S., Singh, S. & Singh, A. P., Aug 1 2020, In: International journal of molecular sciences. 21, 15, p. 1-14 14 p., 5580.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

Co-targeting of CXCR4 and hedgehog pathways disrupts tumor-stromal crosstalk and improves chemotherapeutic efficacy in pancreatic cancer

Khan, M. A., Srivastava, S. K., Zubair, H., Patel, G. K., Arora, S., Moh'd, K., Carter, J. E., Gorman, G. S., Singh, S. & Singh, A. P., Jun 19 2020, In: Journal of Biological Chemistry. 295, 25, p. 8413-8424 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

27 Scopus citations

Epidermal growth factor receptor-activating mutation(E746_T751>VP) in pancreatic ductal adenocarcinoma responds to erlotinib, followed by epidermal growth factor receptor resistance-mediating mutation (A647T): A case report and literature review

Patel, G., Perry, J., Abdul-Rahim, O., Frankel, A., Cameron, D., Taylor, W., Rocconi, R., Abushahin, L., Nelson, C., Singh, A. & Khushman, MD., Jul 1 2020, In: Journal of cancer research and therapeutics. 16, 4, p. 950-954 5 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

5 Scopus citations

Exosomal formulation escalates cellular uptake of honokiol leading to the enhancement of its antitumor efficacy

Kanchanapally, R., Khan, M. A., Deshmukh, S. K., Srivastava, S. K., Khushman, M., Singh, S. & Singh, A. P., Sep 15 2020, In: ACS Omega. 5, 36, p. 23299-23307 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

21 Scopus citations

Prolonged response to liposomal irinotecan in a patient with stage iv pancreatic/bile duct cancer previously treated with FOLFIRINOX and gemcitabine plus nab-paclitaxel

Surinach, A., Phung, T., Abdul-Rahim, O. & Khushman, M., 2020, In: Current Oncology. 27, 2, p. e222-e225

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Usefulness of Restaging Pelvis Magnetic Resonance Imaging After Neoadjuvant Concurrent Chemoradiotherapy in Patients With Locally Advanced Rectal Cancer

Fahmawi, Y., Smith, C., Grimm, L., Khullar, S., Rider, P., Hunter, J., Iliff, G., Mneimneh, W., Roveda, K., Wang, B., Prodduturvar, P., Alkharabsheh, O., McCormick, B., Mizrahi, M. & Khushman, M., Dec 2020, In: Clinical Colorectal Cancer. 19, 4, p. e281-e287

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

2019

Comparative analysis of exosome isolation methods using culture supernatant for optimum yield, purity and downstream applications

Patel, G. K., Khan, M. A., Zubair, H., Srivastava, S. K., Khushman, M., Singh, S. & Singh, A. P., Dec 1 2019, In: Scientific reports. 9, 1, 5335.

Research output: Contribution to journal › Article › peer-review

Open Access

320 Scopus citations

Exosomal markers (CD63 and CD9) expression and their prognostic significance using immunohistochemistry in patients with pancreatic ductal adenocarcinoma

Khushman, M., Patel, G. K., Laurini, J. A., Bhardwaj, A., Roveda, K., Donnell, R., Sherling, K., Case, B., Frankel, A. E., Pai, S., Taylor, W., Tan, M. C. B., Mizrahi, M., Nelson, C., Wyatt, M., Patton, M., McClellan, S., Singh, S., Wang, B. & Singh, A. P., 2019, In: Journal of Gastrointestinal Oncology. 10, 4, p. 695-702 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

The Prevalence of DPYD*9A (c.85T>C) Genotype and the Genotype-Phenotype Correlation in Patients with Gastrointestinal Malignancies Treated With Fluoropyrimidines: Updated Analysis

Maharjan, A. S., McMillin, G. A., Patel, G. K., Awan, S., Taylor, W. R., Pai, S., Frankel, A. E., Nelson, C., Wang, B., Hosein, P. J., Singh, A. P. & Khushman, M., Sep 2019, In: Clinical Colorectal Cancer. 18, 3, p. e280-e286

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Vitamin B12 deficiency presenting as pseudothrombotic microangiopathy: A case report and literature review

Fahmawi, Y., Campos, Y., Khushman, M., Alkharabsheh, O., Manne, A., Zubair, H., Haleema, S., Polski, J. & Bessette, S., 2019, In: Clinical Pharmacology: Advances and Applications. 11, p. 127-131 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

2018

Exosomes: Key supporters of tumor metastasis

Patel, G. K., Zubair, H., Khan, M. A., Srivastava, S. K., Ahmad, A., Patton, M. C., Singh, S., Khushman, M. & Singh, A. P., Jan 1 2018, Diagnostic and Therapeutic Applications of Exosomes in Cancer. Elsevier, p. 261-283 23 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

9 Scopus citations

Germline pharmacogenomics of DPYD*9A (c.85T>C) variant in patients with gastrointestinal malignancies treated with fluoropyrimidines

Khushman, M., Patel, G. K., Hosein, P. J., Laurini, J. A., Cameron, D., Clarkson, D. R., Butler, T. W., Norden, C. W., Baliem, W., Jones, V., Bhadkamkar, S., Nelson, C., Lee, F., Singh, A. P. & Taylor, W. R., Jun 1 2018, In: Journal of Gastrointestinal Oncology. 9, 3, p. 416-424 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Scopus citations

2017

Exosomal markers (CD63 and CD9) expression pattern using immunohistochemistry in resected malignant and nonmalignant pancreatic specimens

Khushman, M., Bhardwaj, A., Patel, G. K., Laurini, J. A., Roveda, K., Tan, M. C., Patton, M. C., Singh, S., Taylor, W. & Singh, A. P., 2017, In: Pancreas. 46, 6, p. 782-788 7 p.

Research output: Contribution to journal › Article › peer-review

59 Scopus citations

Exosomes confer chemoresistance to pancreatic cancer cells by promoting ROS detoxification and miR-155-mediated suppression of key gemcitabine-metabolising enzyme, DCK

Patel, G. K., Khan, M. A., Bhardwaj, A., Srivastava, S. K., Zubair, H., Patton, M. C., Singh, S., Khushman, MD. & Singh, A. P., Feb 28 2017, In: British Journal of Cancer. 116, 5, p. 609-619 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

187 Scopus citations

Molecular drivers of pancreatic cancer pathogenesis: Looking inward to move forward

Khan, M. A., Azim, S., Zubair, H., Bhardwaj, A., Patel, G. K., Khushman, MD., Singh, S. & Singh, A. P., Apr 6 2017, In: International journal of molecular sciences. 18, 4, 779.

Research output: Contribution to journal › Review article › peer-review

Open Access

45 Scopus citations

Syndrome of Inappropriate Anti-Diuretic Hormone Secretion Secondary to Strongyloides stercoralis Infection in an Allogeneic Stem Cell Transplant Patient: A Case Report and Literature Review

Khushman, M., Morris, M. I., Diaz, L., Goodman, M., Pereira, D., Fuller, K., Garcia-Buitrago, M., Moshiree, B., Zelaya, S., Nayer, A., Benjamin, C. L. & Komanduri, K. V., Mar 1 2017, In: Transplantation Proceedings. 49, 2, p. 373-377 5 p.

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

2016

Deep sequencing and in silico analyses identify MYB-regulated gene networks and signaling pathways in pancreatic cancer

Azim, S., Zubair, H., Srivastava, S. K., Bhardwaj, A., Zubair, A., Ahmad, A., Singh, S., Khushman, MD. & Singh, A. P., Jun 29 2016, In: Scientific reports. 6, 28446.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Scopus citations

Honokiol suppresses pancreatic tumor growth, metastasis and desmoplasia by interfering with tumor-stromal cross-talk

Averett, C., Bhardwaj, A., Arora, S., Srivastava, S. K., Khan, M. A., Ahmad, A., Singh, S., Carter, J. E., Khushman, M. & Singh, A. P., Nov 1 2016, In: Carcinogenesis. 37, 11, p. 1052-1061 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

26 Scopus citations

MYB promotes desmoplasia in pancreatic cancer through direct transcriptional up-regulation and cooperative action of sonic hedgehog and adrenomedullin

Bhardwaj, A., Srivastava, S. K., Singh, S., Tyagi, N., Arora, S., Carter, J. E., Khushman, M. & Singh, A. P., Jul 29 2016, In: Journal of Biological Chemistry. 291, 31, p. 16263-16270 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Scopus citations

2015

Full dose neoadjuvant FOLFIRINOX is associated with prolonged survival in patients with locally advanced pancreatic adenocarcinoma

Khushman, MD., Dempsey, N., Cudris Maldonado, J., Loaiza-Bonilla, A., Velez, M., Carcas, L., Dammrich, D., Hurtado-Cordovi, J., Parajuli, R., Pollack, T., Harwood, A. P., Macintyre, J., Tzeng, C. W. D., Merchan, J. R., Restrepo, M. H., Akunyili, I. I., Ribeiro, A., Narayanan, G., Portelance, L., Sleeman, D., & 3 othersLevi, J. U., Rocha Lima, C. M. S. & Hosein, P. J., 2015, In: Pancreatology. 15, 6, p. 667-673 7 p.

Research output: Contribution to journal › Article › peer-review

72 Scopus citations

2011

Severe lactic acidosis in a patient with metastatic prostate cancer

Munoz, J., Mohd Khushman, M. K., Amr Hanbali, A. H. & Stoltenberg, M., Apr 2011, In: Journal of cancer research and therapeutics. 7, 2, p. 201-202 2 p.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

Mohd Khushman

Research output

Search results