Personal profile
Research interests
Research in my lab at Washington University focuses on the biology of centrosomes and cilia, the involvement of these essential cellular organelles in development, and their dysfunction in human disease. We have developed innovative in vitro and in vivo systems focused on: (1) identifying regulators of centrosome and cilium assembly, using transgenic mouse strains and ex vivo cell culture systems, and (2) determining the consequences of abnormal centrosome and cilium biogenesis in mammalian development, with specific focus on cystic kidney disease.
Available to Mentor:
- PhD Students
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Collaborations and top research areas from the last five years
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Regulation of TFEB in human placental Cytotrophoblasts and Syncytiotrophoblasts
Mathew, A., Trausch-Azar, J. S., Azar, C., Schuetz, M., Mahjoub, M. R. & Schwartz, A. L., May 2025, In: Physiological Reports. 13, 10, e70383.Research output: Contribution to journal › Article › peer-review
Open Access -
The Heterotaxy Gene CCDC11 Is Important for Cytokinesis via RhoA Regulation
Kulkarni, S. S., Stephenson, R. E., Amalraj, S., Arrigo, A., Betleja, E., Moresco, J. J., Yates, J. R., Mahjoub, M. R., Miller, A. L. & Khokha, M. K., Jun 2025, In: Cytoskeleton. 82, 6, p. 360-371 12 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Link opens in a new tab Scopus citations -
Undocking of an extensive ciliary network induces proteostasis and cell fate switching resulting in severe primary ciliary dyskinesia
Brody, S. L., Pan, J., Huang, T., Xu, J., Xu, H., Koenitizer, J. R., Brennan, S. K., Nanjundappa, R., Saba, T. G., Rumman, N., Berical, A., Hawkins, F. J., Wang, X., Zhang, R., Mahjoub, M. R., Horani, A. & Dutcher, S. K., Jan 29 2025, In: Science translational medicine. 17, 783, eadp5173.Research output: Contribution to journal › Article › peer-review
13 Link opens in a new tab Scopus citations -
Cep120 is essential for kidney stromal progenitor cell growth and differentiation
Langner, E., Cheng, T., Kefaloyianni, E., Gluck, C., Wang, B. & Mahjoub, M. R., Jan 12 2024, In: EMBO Reports. 25, 1, p. 428-454 27 p.Research output: Contribution to journal › Article › peer-review
Open Access8 Link opens in a new tab Scopus citations -
DLG1 functions upstream of SDCCAG3 and IFT20 to control ciliary targeting of polycystin-2
Rezi, C. K., Aslanyan, M. G., Diwan, G. D., Cheng, T., Chamlali, M., Junger, K., Anvarian, Z., Lorentzen, E., Pauly, K. B., Afshar-Bahadori, Y., Fernandes, E. F. A., Qian, F., Tosi, S., Christensen, S. T., Pedersen, S. F., Strømgaard, K., Russell, R. B., Miner, J. H., Mahjoub, M. R. & Boldt, K. & 2 others, , Jul 11 2024, In: EMBO Reports. 25, 7, p. 3040-3063 24 p.Research output: Contribution to journal › Article › peer-review
Open Access8 Link opens in a new tab Scopus citations