Research output per year
Research output per year
Personal profile
Research interests
Research in my lab at Washington University focuses on the biology of centrosomes and cilia, the involvement of these essential cellular organelles in development, and their dysfunction in human disease. We have developed innovative in vitro and in vivo systems focused on: (1) identifying regulators of centrosome and cilium assembly, using transgenic mouse strains and ex vivo cell culture systems, and (2) determining the consequences of abnormal centrosome and cilium biogenesis in mammalian development, with specific focus on cystic kidney disease.
Available to Mentor:
- PhD/MSTP Students
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Collaborations and top research areas from the last five years
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Cep120 is essential for kidney stromal progenitor cell growth and differentiation
Langner, E., Cheng, T., Kefaloyianni, E., Gluck, C., Wang, B. & Mahjoub, M. R., Jan 12 2024, In: EMBO Reports. 25, 1, p. 428-454 27 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
DLG1 functions upstream of SDCCAG3 and IFT20 to control ciliary targeting of polycystin-2
Rezi, C. K., Aslanyan, M. G., Diwan, G. D., Cheng, T., Chamlali, M., Junger, K., Anvarian, Z., Lorentzen, E., Pauly, K. B., Afshar-Bahadori, Y., Fernandes, E. F. A., Qian, F., Tosi, S., Christensen, S. T., Pedersen, S. F., Strømgaard, K., Russell, R. B., Miner, J. H., Mahjoub, M. R. & Boldt, K. & 2 others, , Jul 11 2024, In: EMBO Reports. 25, 7, p. 3040-3063 24 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Inhibiting centrosome clustering reduces cystogenesis and improves kidney function in autosomal dominant polycystic kidney disease
Cheng, T., Mariappan, A., Langner, E., Shim, K., Gopalakrishnan, J. & Mahjoub, M. R., 2024, In: JCI Insight. 9, 4, e172047.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Multiomics profiling of mouse polycystic kidney disease progression at a single-cell resolution
Muto, Y., Yoshimura, Y., Wu, H., Chang-Panesso, M., Ledru, N., Woodward, O. M., Outeda, P., Cheng, T., Mahjoub, M., Watnick, T. J. & Humphreys, B., Oct 22 2024, In: Proceedings of the National Academy of Sciences of the United States of America. 121, 43, e2410830121.Research output: Contribution to journal › Article › peer-review
Open Access -
The Heterotaxy Gene CCDC11 Is Important for Cytokinesis via RhoA Regulation
Kulkarni, S., Stephenson, R., Amalraj, S., Arrigo, A., Betleja, E., Moresco, J., Yates, J., Mahjoub, M., Miller, A. & Khokha, M., 2024, (Accepted/In press) In: Cytoskeleton.Research output: Contribution to journal › Article › peer-review
Open Access