Moe Mahjoub

Assistant Professor of Medicine, Assistant Professor of Cell Biology and Physiology

  • 975 Citations
20022019
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Personal profile

Research interests

Research in my lab at Washington University focuses on the biology of centrosomes and cilia, the involvement of these essential cellular organelles in development, and their dysfunction in human disease. We have developed innovative in vitro and in vivo systems focused on: (1) identifying regulators of centrosome and cilium assembly, using transgenic mouse strains and ex vivo cell culture systems, and (2) determining the consequences of abnormal centrosome and cilium biogenesis in mammalian development, with specific focus on cystic kidney disease.

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  • 2 Similar Profiles
Cilia Medicine & Life Sciences
Centrioles Medicine & Life Sciences
Centrosome Medicine & Life Sciences
Chlamydomonas Medicine & Life Sciences
Autosomal Dominant Polycystic Kidney Medicine & Life Sciences
Microtubules Medicine & Life Sciences
Cell Cycle Medicine & Life Sciences
Kidney Medicine & Life Sciences

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Research Output 2002 2019

  • 975 Citations
  • 23 Article
  • 1 Comment/debate
  • 1 Short survey
  • 1 Review article

High-resolution characterization of centriole distal appendage morphology and dynamics by correlative STORM and electron microscopy

Bowler, M., Kong, D., Sun, S., Nanjundappa, R., Evans, L., Farmer, V., Holland, A., Mahjoub, M. R., Sui, H. & Loncarek, J., Dec 1 2019, In : Nature communications. 10, 1, 993.

Research output: Contribution to journalArticle

appendages
Centrioles
Electron microscopy
electron microscopy
Electron Microscopy

New pathogenic insights inform therapeutic target development for renal osteodystrophy

Hruska, K. A. & Mahjoub, M. R., Feb 2019, In : Kidney International. 95, 2, p. 261-263 3 p.

Research output: Contribution to journalComment/debate

Chronic Kidney Disease-Mineral and Bone Disorder
Autosomal Dominant Polycystic Kidney
Parathyroid Hormone
Osteocytes
Disease Resistance
2 Citations (Scopus)

Regulation of cilia abundance in multiciliated cells

Nanjundappa, R., Kong, D., Shim, K., Stearns, T., Brody, S. L., Loncarek, J. & Mahjoub, M. R., Apr 2019, In : eLife. 8, e44039.

Research output: Contribution to journalArticle

Open Access
Centrioles
Cilia
Amplification
Ablation
Fluids
3 Citations (Scopus)

A novel cep120-dependent mechanism inhibits centriole maturation in quiescent cells

Betleja, E., Nanjundappa, R., Cheng, T. & Mahjoub, M. R., May 9 2018, In : eLife. 7, e35439.

Research output: Contribution to journalArticle

Open Access
Centrioles
Centrosome
Dyneins
Proteins
Nucleation
3 Citations (Scopus)

Arginine reprogramming in ADPKD results in arginine-dependent cystogenesis

Trott, J. F., Hwang, V. J., Ishimaru, T., Chmiel, K. J., Zhou, J. X., Shim, K., Stewart, B. J., Mahjoub, M. R., Jen, K. Y., Barupal, D. K., Li, X. & Weiss, R. H., Dec 1 2018, In : American journal of physiology. Renal physiology. 315, 6, p. F1855-F1868

Research output: Contribution to journalArticle

Autosomal Dominant Polycystic Kidney
Arginine
Glutamine
Renal Cell Carcinoma
Metabolic Diseases